scholarly journals Levels of the soluble, 55-kilodalton isoform of tumor necrosis factor receptor in bone marrow are correlated with the clinical outcome of children with acute lymphoblastic leukemia in first recurrence

Cancer ◽  
2003 ◽  
Vol 98 (3) ◽  
pp. 625-631 ◽  
Author(s):  
Shuling Wu ◽  
Alexander Korte ◽  
Reinhard Gessner ◽  
Guenter Henze ◽  
Karlheinz Seeger
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Tumor Necrosis Factor ◽  
Clinical Outcome ◽  
Tumor Necrosis ◽  
Lymphoblastic Leukemia ◽  
Tumor Necrosis Factor Receptor ◽  
First Recurrence ◽  
Necrosis Factor

TUMOR NECROSIS FACTOR RECEPTOR REGULATION OF BONE MARROW CELL APOPTOSIS DURING ENDOTOXIN-INDUCED SYSTEMIC INFLAMMATION

Shock ◽  
2006 ◽  
Vol 25 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Joji Kotani ◽  
Nicholas J. Avallone ◽  
Edward Lin ◽  
Masahiro Goshima ◽  
Stephen F. Lowry ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Necrosis Factor ◽  
Bone Marrow Cell ◽  
Systemic Inflammation ◽  
Cell Apoptosis ◽  
Tumor Necrosis ◽  
Marrow Cell ◽  
Tumor Necrosis Factor Receptor ◽  
Receptor Regulation ◽  
Necrosis Factor

scholarly journals Hypercalcemia with multiple osteolytic lesions and increased circulating tumor necrosis factor in an adult patient with B-cell acute lymphoblastic leukemia

2016 ◽  
Vol 144 (3-4) ◽  
pp. 207-210 ◽  
Author(s):  
Marijana Virijevic ◽  
Ana Vidovic ◽  
Natasa Colovic ◽  
Irena Djunic ◽  
Mirjana Mitrovic ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tumor Necrosis Factor ◽  
B Cell ◽  
Tumor Necrosis ◽  
Lymphoblastic Leukemia ◽  
Pathogenic Factor ◽  
Clinical Context ◽  
Osteolytic Lesions ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Necrosis Factor

Introduction. Acute lymphoblastic leukemia (ALL) is very rarely presented with diffuse osteolytic lesions and hypercalcemia. Case Outline. We report a 28-year-old male with the B-cell ALL who presented with extensive osteolytic lesions, bone pain, hepatosplenomegaly, and pancytopenia without circulating blasts in peripheral blood. An increased serum level of tumor necrosis factor (TNF-?) was registered while the levels of IL-1? and IL-1? were normal. The patient failed to achieve remission on two induction regimens but achieved one after the successful allogeneic stem cell transplantation, which lasted for six months, after which he developed a relapse and died. Conclusion. The presented case may serve as a clinical demonstration of possible involvement of TNF-? as a pathogenic factor in the evolution of osteolytic lesions that are occasionally observed in patients with ALL. This might have relevance in the management of such patients as chemotherapy alone may not represent the beneficial option in this clinical context.

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