Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriers

Cancer ◽  
2002 ◽  
Vol 97 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Camilo Adem ◽  
Carol Reynolds ◽  
Cheryl L. Soderberg ◽  
Jeffrey M. Slezak ◽  
Shannon K. McDonnell ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Breast Parenchyma ◽  
Mutation Carriers ◽  
Hereditary Breast Carcinoma

A history of breast carcinoma predicts worse survival in BRCA1 and BRCA2 mutation carriers with ovarian carcinoma

2011 ◽  
Vol 120 ◽  
pp. S22-S23
Author(s):  
B. Norquist ◽  
R. Garcia ◽  
K. Agnew ◽  
J. Gross ◽  
R. Swensen ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Ovarian Carcinoma ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers ◽  
History Of

scholarly journals A new hybrid record linkage process to make epidemiological databases interoperable: application to the GEMO and GENEPSO studies involving BRCA1 and BRCA2 mutation carriers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yue Jiao ◽  
Fabienne Lesueur ◽  
Chloé-Agathe Azencott ◽  
Maïté Laurent ◽  
Noura Mebirouk ◽  
...  
Keyword(s):  
Record Linkage ◽  
Gold Standard ◽  
Brca2 Mutation ◽  
Epidemiological Studies ◽  
Supervised Machine Learning ◽  
Training Dataset ◽  
Support Vector ◽  
Genetic Modifiers ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

Abstract Background Linking independent sources of data describing the same individuals enable innovative epidemiological and health studies but require a robust record linkage approach. We describe a hybrid record linkage process to link databases from two independent ongoing French national studies, GEMO (Genetic Modifiers of BRCA1 and BRCA2), which focuses on the identification of genetic factors modifying cancer risk of BRCA1 and BRCA2 mutation carriers, and GENEPSO (prospective cohort of BRCAx mutation carriers), which focuses on environmental and lifestyle risk factors. Methods To identify as many as possible of the individuals participating in the two studies but not registered by a shared identifier, we combined probabilistic record linkage (PRL) and supervised machine learning (ML). This approach (named “PRL + ML”) combined together the candidate matches identified by both approaches. We built the ML model using the gold standard on a first version of the two databases as a training dataset. This gold standard was obtained from PRL-derived matches verified by an exhaustive manual review. Results The Random Forest (RF) algorithm showed a highest recall (0.985) among six widely used ML algorithms: RF, Bagged trees, AdaBoost, Support Vector Machine, Neural Network. Therefore, RF was selected to build the ML model since our goal was to identify the maximum number of true matches. Our combined linkage PRL + ML showed a higher recall (range 0.988–0.992) than either PRL (range 0.916–0.991) or ML (0.981) alone. It identified 1995 individuals participating in both GEMO (6375 participants) and GENEPSO (4925 participants). Conclusions Our hybrid linkage process represents an efficient tool for linking GEMO and GENEPSO. It may be generalizable to other epidemiological studies involving other databases and registries.

Weight gain and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers

2021 ◽  
Vol 132 ◽  
pp. S357-S358
Author(s):  
Shana Kim ◽  
Jan Lubinski ◽  
Tomasz Huzarski ◽  
Pal Moller ◽  
Susan Armel ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Weight Gain ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

scholarly journals Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry

2015 ◽  
Vol 151 (3) ◽  
pp. 653-660 ◽  
Author(s):  
Tehillah S. Menes ◽  
Mary Beth Terry ◽  
David Goldgar ◽  
Irene L. Andrulis ◽  
Julia A. Knight ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Incidence ◽  
Primary Breast Cancer ◽  
Brca2 Mutation ◽  
Second Primary ◽  
Brca1 And Brca2 ◽  
Breast Cancer Family ◽  
Cancer Family ◽  
Mutation Carriers

scholarly journals The frequency and outcome of breast cancer risk-reducing surgery in finnish BRCA1 and BRCA2 mutation carriers

2013 ◽  
Vol 103 (1) ◽  
pp. 34-40 ◽  
Author(s):  
L. Koskenvuo ◽  
C. Svarvar ◽  
S. Suominen ◽  
K. Aittomäki ◽  
T. Jahkola
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers ◽  
Risk Reducing

The CYP17A1 −34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers

2010 ◽  
Vol 126 (2) ◽  
pp. 521-527 ◽  
Author(s):  
Bella Kaufman ◽  
Yael Laitman ◽  
Elad Ziv ◽  
Ute Hamann ◽  
Diana Torres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

scholarly journals Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

2011 ◽  
Vol 104 (9) ◽  
pp. 1384-1392 ◽  
Author(s):  
K Metcalfe ◽  
S Gershman ◽  
H T Lynch ◽  
P Ghadirian ◽  
N Tung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Brca2 Mutation ◽  
Contralateral Breast ◽  
Brca1 And Brca2 ◽  
Mutation Carriers
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