scholarly journals Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women

Cancer ◽  
2002 ◽  
Vol 94 (3) ◽  
pp. 615-623 ◽  
Author(s):  
Indra Poola ◽  
Robert Clarke ◽  
Robert DeWitty ◽  
LaSelle D. Leffall
Keyword(s):  
Estrogen Receptor ◽  
African American ◽  
African American Women ◽  
Breast Tumors ◽  
American Women ◽  
Caucasian Women

Abstract 5247: Aspirin use and estrogen receptor-negative breast cancer risk in African American women

2018 ◽  
Author(s):  
Kimberly A. Bertrand ◽  
Traci N. Bethea ◽  
Hanna Gerlovin ◽  
Patricia Coogan ◽  
Lucile L. Adams-Campbell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
African American ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
African American Women ◽  
American Women ◽  
Estrogen Receptor Negative

Mammography screening and detection of early stage breast cancer in Hispanic and African American women at a Minnesota safety net healthcare system.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18074-e18074
Author(s):  
Daniel Fellows Pease ◽  
David T. Gilbertson ◽  
Andres Wiernik
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Healthcare System ◽  
Early Stage ◽  
Screening Mammography ◽  
Advanced Stage ◽  
American Women ◽  
Younger Age ◽  
Caucasian Women

e18074 Background: Approximately 12% of breast cancer cases occur in women younger than 50 years, per SEER data from 2012. Hispanic women are known to present at a younger age and African American women with more advanced stage disease. In this study, we describe the impact of age and race on the initial presentation of breast cancer among minority women treated at the Hennepin Healthcare System (HHS) in the state of Minnesota. Methods: A single-institution retrospective analysis of data from our electronic health record of all breast cancer diagnoses from 2010-2015. Cases were compared by age ( < 50 or > 50 years), race (Caucasian, African American, Hispanic, other), stage (AJCC 7th edition), and method of diagnosis (self-reported mass or screening mammography). Results: A total of 315 breast cancer diagnoses occurred at HHS from 2010-2015. In our cohort, 29% of all breast cancer cases were diagnosed in women < 50yrs. Hispanic and African American women had higher rates of diagnosis at < 50yrs compared to Caucasian women (38.9% vs 37.1% vs 18.1 respectively, p < 0.05). Early stage cancer (stage 0 or I) accounted for most diagnoses in those > 50yrs (54.8%), while advanced stage (stage II-IV) was more prevalent in the < 50yrs age group (59.5%) (p < 0.05). Of all women diagnosed with breast cancer, 63% presented with a self-reported mass and 37% were diagnosed by screening mammography. Hispanics and African American women had a higher rate of presentation with a self-reported mass (74% and 66% respectively) compared to Caucasian women (55%). Women with breast cancer < 50yrs were more likely to present with a self-reported mass than women > 50yrs (80% vs 55%, p < 0.05). 92% of Hispanic and 80% of African American women < 50yrs presented with a self-reported mass, compared to 62% of Caucasian women (p = 0.095). Conclusions: At our institution, Hispanic and African American women are diagnosed at a significantly younger age than Caucasian women, and those diagnosed at a younger age have more advanced disease. Presenting with a self-reported mass is very common for young non-Caucasian women. Whether screening mammography can be better utilized to change these trends requires further study.

scholarly journals Parity and Lactation in Relation to Estrogen Receptor Negative Breast Cancer in African American Women

2011 ◽  
Vol 20 (9) ◽  
pp. 1883-1891 ◽  
Author(s):  
Julie R. Palmer ◽  
Deborah A. Boggs ◽  
Lauren A. Wise ◽  
Christine B. Ambrosone ◽  
Lucile L. Adams-Campbell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
African American ◽  
African American Women ◽  
American Women ◽  
Estrogen Receptor Negative

Ethnic differences in in vitro glyceride synthesis in subcutaneous and omental adipose tissue

2002 ◽  
Vol 283 (5) ◽  
pp. E988-E993 ◽  
Author(s):  
J. F. Bower ◽  
S. Vadlamudi ◽  
H. A. Barakat
Keyword(s):  
Adipose Tissue ◽  
African American ◽  
African American Women ◽  
Ethnic Differences ◽  
American Woman ◽  
Morbidly Obese ◽  
American Women ◽  
Omental Adipose Tissue ◽  
Caucasian Women

Considerable evidence suggests that there are ethnic differences in lipid metabolism between African American and Caucasian women, which may result in increased synthesis of fat in adipose tissue. The purpose of this study was to measure the in vitro rates of [14C]glucose incorporation into the glyceride-glycerol backbone of triglycerides (TG) and diglycerides (DG) in abdominal subcutaneous (SAT) and omental adipose tissue (OAT). Morbidly obese [African American ( n = 15): body mass index (BMI) = 45 ± 2.3; Caucasian ( n = 18): BMI = 51 ± 2.3] and preobese [African American ( n = 7): BMI = 27 ± 1.0; Caucasian ( n = 7): BMI = 25 ± 1.0] women were examined in this study. There were no significant differences in the rates of synthesis of either TG or DG in SAT of either preobese or obese women. On the other hand, both preobese and obese African American women had higher rates of synthesis of TG in OAT compared with their Caucasian counterparts. This increase in TG synthesis in OAT was not due to differences in cell size or rates of reesterification. Thus African American woman have an increased capacity to synthesize TG in OAT compared with Caucasian women, which may contribute to the higher prevalence of obesity in African American women.

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