CMR 2005: 8.02: Fibrin-directed nanoparticles for combined imaging and local thrombolytic therapy

2006 ◽  
Vol 1 (2) ◽  
pp. 73-73
Author(s):  
J.N. Marsh ◽  
M.S. Hughes ◽  
P.J. Gaffney ◽  
M.J. Scott ◽  
S.A. Wickline ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Combined Imaging ◽  
Local Thrombolytic Therapy

Abdominal Pain Secondary to Pylephlebitis: An Uncommon Disease of the Portal Venous System, Treated with Local Thrombolytic Therapy

2005 ◽  
Vol 50 (5) ◽  
pp. 983-987 ◽  
Author(s):  
Rathnakara Sherigar ◽  
Khalil A. Amir ◽  
Ravi K. Bobba ◽  
Edward L. Arsura ◽  
Narain Srinivas
Keyword(s):  
Abdominal Pain ◽  
Thrombolytic Therapy ◽  
Venous System ◽  
Portal Venous System ◽  
Uncommon Disease ◽  
Local Thrombolytic Therapy

scholarly journals Local Thrombolytic Therapy for Primary Axillosubclavian Vein Thrombosis

2010 ◽  
Vol 1 (1) ◽  
pp. 1-2
Author(s):  
Isabella Maund ◽  
Edward Banham-Hall ◽  
Robert Mallinson
Keyword(s):  
Thrombolytic Therapy ◽  
Vein Thrombosis ◽  
Local Thrombolytic Therapy

Systemic Thrombolytic Therapy and Catheter-Directed Fragmentation with Local Thrombolytic Therapy in Patients with Pulmonary Embolism

2017 ◽  
Vol 45 ◽  
pp. 98-105 ◽  
Author(s):  
Julia Klevanets ◽  
Vladimir Starodubtsev ◽  
Pavel Ignatenko ◽  
Olga Voroshilina ◽  
Pavel Ruzankin ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Systemic Thrombolytic Therapy ◽  
Local Thrombolytic Therapy

Risks and benefits of transcatheter thrombolytic therapy in patients with splanchnic venous thrombosis

2008 ◽  
Vol 100 (12) ◽  
pp. 1084-1088 ◽  
Author(s):  
Jasper H. Smalberg ◽  
Manon V. M. C. W. Spaander ◽  
Kon-Siong G. Jie ◽  
Peter M. T. Pattynama ◽  
Henk R. van Buuren ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Venous Thrombosis ◽  
Fatal Outcome ◽  
High Rate ◽  
Venous Flow ◽  
Vein Thrombosis ◽  
Single Center Experience ◽  
Major Procedure ◽  
Local Thrombolytic Therapy ◽  
Minor Procedure

SummaryTranscatheter local thrombolytic therapy in patients with acute, extended splanchnic venous thrombosis is controversial. Here we present our single-center experience with transcatheter thrombolytic therapy in these patients. All consecutive patients (n=12) with acute,extended splanchnic venous thrombosis who underwent transcatheter thrombolytic therapy in our hospital, were included in this study. Thrombolytic therapy was successful for three thrombotic events and partially successful for four thrombotic events.Two patients developed minor procedure-related bleeding (17%).Six patients (50%) developed major procedure-related bleeding, with a fatal outcome in two. Transcatheter thrombolytic therapy in patients with acute, extended splanchnic vein thrombosis is found to be associated with a high rate of procedure-related bleeding. Therefore, thrombolysis should be reserved for patients in whom the venous flow cannot be restored by using conventional anticoagulant therapy or stent placement across the thrombosed vessel segment.H.L.A. Janssen and F.W.G. Leebeek are both Clinical Fellows of the Netherlands Organisation for Scientific Research (NWO).

D-Dimer in Local Thrombolytic Therapy with Low Doses of Recombinant Human Tissue-Type Plasminogen Activator (rt-PA) in Patients with Peripheral Arterial Occlusive Disease

1990 ◽  
Vol 64 (02) ◽  
pp. 192-195 ◽  
Author(s):  
Renate Koppensteiner ◽  
Wolfgang Speiser ◽  
Erich Minar ◽  
Ramazan Ahmadi ◽  
Herbert Ehringer
Keyword(s):  
Thrombolytic Therapy ◽  
Plasminogen Activator ◽  
Human Tissue ◽  
Tissue Type ◽  
Low Doses ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Local Thrombolytic Therapy ◽  
Peripheral Arterial ◽  
D Dimer

SummaryThe generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen after intravenous application of manifold higher doses used in myocardial infarction. The increase in D-dimer was related to the estimated thrombus size (length of the occlusion) and the total dose of rt-PA applied. During local rt-PA infusion 6 of 7 patients maintained plasminogen activator inhibitor capacity (PAI-cap) between 34% and 79% of their corresponding pre-treatment levels; detectable levels of PAI-cap in circulating blood during the procedure did not interfere with the success of therapy.

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