CMR 2007: 4.03: High-throughputin vivo screening of targeted molecular imaging agents using PET

2007 ◽  
Vol 2 (6) ◽  
pp. 283-284
Author(s):  
M. K. J. Gagnon ◽  
J. Marik ◽  
S. H. Hausner ◽  
D. L. Kukis ◽  
C. K. Abbey ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Molecular Imaging Agents ◽  
Targeted Molecular Imaging

Targeted Molecular Imaging Agents for Cellular-Scale Bimodal Imaging

2004 ◽  
Vol 15 (6) ◽  
pp. 1488-1495 ◽  
Author(s):  
H. Charles Manning ◽  
Timothy Goebel ◽  
Reid C. Thompson ◽  
Ronald R. Price ◽  
Haakil Lee ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Bimodal Imaging ◽  
Molecular Imaging Agents ◽  
Targeted Molecular Imaging

scholarly journals High-throughput in vivo screening of targeted molecular imaging agents

2009 ◽  
Vol 106 (42) ◽  
pp. 17904-17909 ◽  
Author(s):  
M. K. J. Gagnon ◽  
S. H. Hausner ◽  
J. Marik ◽  
C. K. Abbey ◽  
J. F. Marshall ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
High Throughput ◽  
Imaging Agents ◽  
In Vivo Screening ◽  
Molecular Imaging Agents ◽  
Targeted Molecular Imaging

Abstract 1499: SUPR peptides as novel targeted molecular imaging agents for Her2

2015 ◽  
Author(s):  
Lindsay Kelderhouse ◽  
Amanda Hardy ◽  
Terry T. Takahashi ◽  
Argentina Ornelas ◽  
Seth Gammon ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Molecular Imaging Agents ◽  
Targeted Molecular Imaging

Modular Synthesis of Peptide-Based Single- and Multimodal Targeted Molecular Imaging Agents

2021 ◽  
Author(s):  
Hans F. Schmitthenner ◽  
Taylor M. Barrett ◽  
Stephanie A. Beach ◽  
Lauren E. Heese ◽  
Chelsea Weidman ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Modular Synthesis ◽  
Molecular Imaging Agents ◽  
Targeted Molecular Imaging

scholarly journals A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

2020 ◽  
Vol 13 (8) ◽  
pp. 199
Author(s):  
Joseph Lau ◽  
Julie Rousseau ◽  
Daniel Kwon ◽  
François Bénard ◽  
Kuo-Shyan Lin
Keyword(s):  
Molecular Imaging ◽  
Smooth Muscle Contraction ◽  
Therapeutic Interventions ◽  
Imaging Agents ◽  
Kinin System ◽  
Normal Tissues ◽  
Molecular Imaging Agents ◽  
Inflammatory State ◽  
B2 Receptors ◽  
Tissue Trauma

Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention, smooth muscle contraction, and algesia, while B1R is absent in normal tissues and is induced by tissue trauma or inflammation. B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue. Perturbations of the kinin system have been implicated in inflammation, chronic pain, vasculopathy, neuropathy, obesity, diabetes, and cancer. In general, excess activation and signaling of the kinin system lead to a pro-inflammatory state. Depending on the disease context, agonism or antagonism of the bradykinin receptors have been considered as therapeutic options. In this review, we summarize molecular imaging agents targeting these G protein-coupled receptors, including optical and radioactive probes that have been used to interrogate B1R/B2R expression at the cellular and anatomical levels, respectively. Several of these preclinical agents, described herein, have the potential to guide therapeutic interventions for these receptors.

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