Optimized time-resolved imaging of contrast kinetics (TRICKS) in dynamic contrast-enhanced MRI after peptide receptor radionuclide therapy in small animal tumor models

2015 ◽  
Vol 10 (6) ◽  
pp. 413-420 ◽  
Author(s):  
Joost Haeck ◽  
Karin Bol ◽  
Sander Bison ◽  
Sandra van Tiel ◽  
Stuart Koelewijn ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Small Animal ◽  
Peptide Receptor Radionuclide Therapy ◽  
Time Resolved ◽  
Peptide Receptor ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Animal Tumor ◽  
Time Resolved Imaging ◽  
Contrast Enhanced Mri

scholarly journals Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Thomas Weikert ◽  
Ole Christopher Maas ◽  
Tanja Haas ◽  
Markus Klarhöfer ◽  
Jens Bremerich ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Hepatic Metastases ◽  
Peptide Receptor Radionuclide Therapy ◽  
Therapy Session ◽  
Early Assessment ◽  
Dce Mri ◽  
Peptide Receptor ◽  
Dynamic Contrast Enhanced ◽  
Diffusion Weighted ◽  
Contrast Enhanced

The purpose of this study was to determine if parameters derived from diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) can help to assess early response to peptide receptor radionuclide therapy (PRRT) with 90Y-DOTATOC in neuroendocrine hepatic metastases (NET-HM). Twenty patients (10 male; 10 female; mean age: 59.2 years) with NET-HM were prospectively enrolled in this single-center imaging study. DW-MRI and DCE-MRI studies were performed just before and 48 hours after therapy with 90Y-DOTATOC. Abdominal SPECT/CT was performed 24 hours after therapy. This MRI imaging and therapy session was repeated after a mean interval of 10 weeks. Up to four lesions per patient were evaluated. Response to therapy was evaluated using metastasis sizes at the first and second therapy session as standard for comparison (regressive, stable, and progressive). DW-MRI analysis included the apparent diffusion coefficient (ADC) and parameters related to intravoxel incoherent motion (IVIM), namely, diffusion (D), perfusion fraction (f) and pseudo-diffusion (D∗). DCE-MRI analysis comprised Ktrans, ve and kep. For statistical analysis of group differences, one-way analysis of variance (ANOVA) and appropriate post hoc testing was performed. A total of 51 lesions were evaluated. Seven of 51 lesions (14%) showed size progression, 18/51 (35%) regression, and 26/51 (51%) remained stable. The lesion-to-spleen uptake ratio in SPECT showed a decrease between the two treatment sessions that was significantly stronger in regressive lesions compared with stable (p=0.013) and progressive lesions (p=0.021). ANOVA showed significant differences in mean ADC after 48 h (p=0.026), with higher ADC values for regressive lesions. Regarding IVIM, highest values for D at baseline were seen in regressive lesions (p=0.023). In DCE-MRI, a statistically significant increase in ve after 10 weeks (p=0.046) was found in regressive lesions. No differences were observed for the transfer constants Ktrans and kep. Diffusion restriction quantified as ADC was able to differentiate regressive from progressive NET-HMs as early as 48 hours after PRRT. DW-MRI therefore may complement scintigraphy/SPECT for early assessment of response to PRRT. Assessment of perfusion parameters using IVIM and DCE-MRI did not show an additional benefit.

scholarly journals A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models

2013 ◽  
Vol 40 (2) ◽  
pp. 022304 ◽  
Author(s):  
Ergys Subashi ◽  
Everett J. Moding ◽  
Gary P. Cofer ◽  
James R. MacFall ◽  
David G. Kirsch ◽  
...  
Keyword(s):  
Temporal Resolution ◽  
Small Animal ◽  
Tumor Models ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Animal Tumor ◽  
Contrast Enhanced Mri
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