scholarly journals Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model

2015 ◽  
Vol 10 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Prashant Chandrasekharan ◽  
Chang-Tong Yang ◽  
Fatima Ali Nasrallah ◽  
Hui Chien Tay ◽  
Kai-Hsiang Chuang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Model ◽  
Imaging Studies ◽  
Glioma Tumor

Functional Genomics Guided with MR Imaging: Mouse Tumor Model Study

Radiology ◽  
2003 ◽  
Vol 228 (2) ◽  
pp. 560-568 ◽  
Author(s):  
Samira Guccione ◽  
Yi-Shan Yang ◽  
Gongyi Shi ◽  
Daniel Y. Lee ◽  
King C. P. Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Functional Genomics ◽  
Tumor Model ◽  
Mouse Tumor ◽  
Mouse Tumor Model ◽  
Model Study

Dysprosium-enhanced MR imaging for tumor tissue characterization

1997 ◽  
Vol 38 (2) ◽  
pp. 281-286 ◽  
Author(s):  
C. Wang ◽  
A. Sundin ◽  
A. Ericsson ◽  
T. Bach-Gansmo ◽  
A. Hemmingsson ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tissue Characterization ◽  
Tumor Tissue ◽  
Tumor Model ◽  
Human Colon ◽  
Mr Images ◽  
Histological Sections ◽  
Necrotic Tumor ◽  
Before And After ◽  
Weighted Sequences

Purpose: to evaluate dysprosium-enhanced MR imaging for differentiation between morphologically intact and necrotic tumor tissue in a tumor model. Material and Methods: A human colon carcinoma was transplanted subcutaneously into 9 nude (immunodeprived) rats. MR imaging was performed before and after injection of the dysprosium agent Dy-DTPA-BMA. T1-, T2- and T2*-weighted sequences were acquired. the tumors were dissected, histological sections were prepared, and compared with corresponding MR images. Results: in intact tissue, the MR signal intensity in the T2- and T2*-weighted images decreased after Dy injection and the delineation of the intact regions were sharp and corresponded well to the gross histological sections. Conclusion: Dy-enhanced MR imaging facilitated the differentiation between intact and necrotic tumor tissue.

Liver Tumor Model with Implanted Rhabdomyosarcoma in Rats: MR Imaging, Microangiography, and Histopathologic Analysis

Radiology ◽  
2006 ◽  
Vol 239 (2) ◽  
pp. 554-562 ◽  
Author(s):  
Feng Chen ◽  
Xihe Sun ◽  
Frederik De Keyzer ◽  
Jie Yu ◽  
Ronald Peeters ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Liver Tumor ◽  
Tumor Model ◽  
Histopathologic Analysis

Effectiveness and handling characteristics of a three-layer polymer dura substitute: a prospective multicenter clinical study

2006 ◽  
Vol 105 (6) ◽  
pp. 853-858 ◽  
Author(s):  
A. Martina Messing-Jünger ◽  
Javier Ibáñez ◽  
Fabio Calbucci ◽  
Maurice Choux ◽  
Gabriel Lena ◽  
...  
Keyword(s):  
Clinical Study ◽  
Mr Imaging ◽  
Disease Transmission ◽  
Valsalva Maneuver ◽  
Adhesion Formation ◽  
Type I ◽  
Imaging Studies ◽  
Handling Characteristics ◽  
Csf Leakage ◽  
Multicenter Clinical Study

Object The goal of this study was to assess the effectiveness and handling characteristics of a dura substitute composed of two outer layers of expanded polytetrafluoroethylene (PTFE) and a middle layer consisting of an elastomeric fluoropolymer. Methods In a prospective multicenter study, the dura substitute was implanted using a standard technique in 119 patients undergoing cranial or spinal surgery requiring duraplasty. Intraoperative assessments of the dura patch consisted of testing for cerebrospinal fluid (CSF) leakage employing the Valsalva maneuver and a surgeon’s standard evaluation of the handling characteristics of the device. Postoperative assessments conducted during a mean follow-up time of 15.7 months (range 0.3–45.6 months) consisted of physical examinations, routine computed tomography (CT) or magnetic resonance (MR) imaging studies, and histological studies of any removed dura patches. The mean age of the 119 patients was 40 years (range < 1–81 years). The dura substitute was implanted cranially in 102 patients and spinally in 17. Intraoperative assessment including the Valsalva maneuver led to application of additional sutures in 17 patients. Handling features were rated very good to excellent. Postoperative clinical evaluation resulted in 79 excellent and 18 good results. Imaging studies (MR imaging studies in 69 patients and CT studies in 34 patients) showed no adhesions in 87 patients and minimal adhesions in seven patients (the dura was not visualized in nine patients). Postoperative complications occurred in 12 patients. There were six cases of CSF leakage, three cases of extradural hematoma, one case of arachnoid fibrosis after decompression of a Chiari malformation Type I, and two cases of infection. Eight (7%) of these complications were potentially related to the dura patch. Conclusions In a large, multicenter clinical study of the use of an expanded-PTFE–containing dura substitute, the device was found to be easy to handle and implant. No serious dura patch–related intraoperative adverse events were observed. Postoperatively, there were no major sealing problems or long-term complications. In two cases the patch had to be removed due to fibrosis and infection. The three-layer polymer dura substitute appears to be safe and effective in minimizing CSF leakage and adhesion formation, and its use avoids any risk of prion disease transmission.

In Vivo MR Imaging of Fibrin in a Neuroblastoma Tumor Model by Means of a Targeting Gd-Containing Peptide

2015 ◽  
Vol 17 (6) ◽  
pp. 819-828 ◽  
Author(s):  
L. Chaabane ◽  
L. Tei ◽  
L. Miragoli ◽  
L. Lattuada ◽  
M. von Wronski ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Model ◽  
Neuroblastoma Tumor
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