Nucleophilic cross-linked, dextran coated iron oxide nanoparticles as basis for molecular imaging: synthesis, characterization, visualization and comparison with previous product

2014 ◽  
Vol 10 (1) ◽  
pp. 18-27 ◽  
Author(s):  
Robert Borny ◽  
Thomas Lechleitner ◽  
Thomas Schmiedinger ◽  
Martin Hermann ◽  
Richard Tessadri ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Microwave-Driven Synthesis of Iron-Oxide Nanoparticles for Molecular Imaging

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1224 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
Maria Muñoz-Hernando ◽  
Fernando Herranz
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Microwave Chemistry ◽  
Traditional Methods ◽  
Comprehensive Review

Here, we present a comprehensive review on the use of microwave chemistry for the synthesis of iron-oxide nanoparticles focused on molecular imaging. We provide a brief introduction on molecular imaging, the applications of iron oxide in biomedicine, and traditional methods for the synthesis of these nanoparticles. The review then focuses on the different examples published where the use of microwaves is key for the production of nanoparticles. We study how the different parameters modulate nanoparticle properties, particularly for imaging applications. Finally, we explore principal applications in imaging of microwave-produced iron-oxide nanoparticles.

scholarly journals Nonpolymeric Surface-Coated Iron Oxide Nanoparticles for In Vivo Molecular Imaging: Biodegradation, Biocompatibility, and Multiplatform

2013 ◽  
Vol 54 (11) ◽  
pp. 1974-1980 ◽  
Author(s):  
C.-M. Lee ◽  
S.-J. Cheong ◽  
E.-M. Kim ◽  
S. T. Lim ◽  
Y. Y. Jeong ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 153 ◽  
Author(s):  
Joshua M. Thurman ◽  
Natalie J. Serkova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Iron Oxide ◽  
Molecular Imaging ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Iron Oxide Nanoparticles ◽  
Lupus Erythematosus ◽  
Oxide Nanoparticles ◽  
Systemic Lupus ◽  
Neuropsychiatric Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple different organs, including the kidneys and central nervous system (CNS). Conventional radiological examinations in SLE patients include volumetric/ anatomical computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US). The utility of these modalities is limited, however, due to the complexity of the disease. Furthermore, standard CT and MRI contrast agents are contraindicated in patients with renal impairment. Various radiologic methods are currently being developed to improve disease characterization in patients with SLE beyond simple anatomical endpoints. Physiological non-contrast MRI protocols have been developed to assess tissue oxygenation, glomerular filtration, renal perfusion, interstitial diffusion, and inflammation-driven fibrosis in lupus nephritis (LN) patients. For neurological symptoms, vessel size imaging (VSI, an MRI approach utilizing T2-relaxing iron oxide nanoparticles) has shown promise as a diagnostic tool. Molecular imaging probes (mostly for MRI and nuclear medicine imaging) have also been developed for diagnosing SLE with high sensitivity, and for monitoring disease activity. This paper reviews the challenges in evaluating disease activity in patients with LN and neuropsychiatric systemic lupus erythematosus (NPSLE). We describe novel MRI and positron-emission tomography (PET) molecular imaging protocols using targeted iron oxide nanoparticles and radioactive ligands, respectively, for detection of SLE-associated inflammation.

scholarly journals Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 153
Author(s):  
Joshua M. Thurman ◽  
Natalie J. Serkova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Iron Oxide ◽  
Molecular Imaging ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Iron Oxide Nanoparticles ◽  
Lupus Erythematosus ◽  
Oxide Nanoparticles ◽  
Systemic Lupus ◽  
Neuropsychiatric Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple different organs, including the kidneys and central nervous system (CNS). Conventional radiological examinations in SLE patients include volumetric/ anatomical computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US). The utility of these modalities is limited, however, due to the complexity of the disease. Furthermore, CT and MRI contrast agents are contraindicated in patients with renal impairment. Various radiologic methods are currently being developed to improve disease characterization in patients with SLE beyond simple anatomical endpoints. Physiological non-contrast MRI protocols have been developed to assess tissue oxygenation, glomerular filtration, renal perfusion, interstitial diffusion, and inflammation-driven fibrosis in lupus nephritis (LN) patients. For neurological symptoms, vessel size imaging (VSI, an MRI approach utilizing T2-relaxing iron oxide nanoparticles) has shown promise as a diagnostic tool. Molecular imaging probes (mostly for MRI and nuclear medicine imaging) have also been developed for diagnosing SLE with high sensitivity, and for monitoring disease activity. This paper reviews the challenges in evaluating disease activity in patients with LN and neuropsychiatric systemic lupus erythematosus (NPSLE). We describe novel MRI and positron-emission tomography (PET) molecular imaging protocols using targeted iron oxide nanoparticles and radioactive ligands, respectively, for detection of SLE-associated inflammation.

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Biomaterials ◽  
2017 ◽  
Vol 134 ◽  
pp. 31-42 ◽  
Author(s):  
Hang T. Ta ◽  
Zhen Li ◽  
Christoph E. Hagemeyer ◽  
Gary Cowin ◽  
Shaohua Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Activated Platelets
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