scholarly journals PECAM-1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia

2013 ◽  
Vol 8 (5) ◽  
pp. 393-401 ◽  
Author(s):  
Lisette H. Deddens ◽  
Geralda A. F. van Tilborg ◽  
Annette van der Toorn ◽  
Helga E. de Vries ◽  
Rick M. Dijkhuizen
Keyword(s):  
Iron Oxide ◽  
Cerebral Ischemia ◽  
Contrast Agent ◽  
Vascular Remodeling ◽  
Mri Contrast Agent ◽  
Mri Contrast

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Moderate cooling coprecipitation for extremely small iron oxide as a pH dependent T1-MRI contrast agent

Nanoscale ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 5521-5532 ◽  
Author(s):  
Bo Chen ◽  
Zhanhang Guo ◽  
Chunxian Guo ◽  
Yu Mao ◽  
Zhiguo Qin ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Ph Dependent

Moderate cooling coprecipitation for monodisperse extremely small iron oxide as a pH dependent T1-MRI contrast agent.

scholarly journals Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent

2021 ◽  
Author(s):  
Joong Kim ◽  
Wen-Tung Wang ◽  
Andrew Knutsen ◽  
David Brody
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Digital Simulation ◽  
Brain Mri ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Simulation Approach ◽  
Mri Contrast ◽  
Mr Relaxation

Abstract There have been substantial efforts to develop targeted exogenous MRI contrast agents to assess specific brain pathologies. In parallel with other efforts, it is important to assess the sensitivity of candidate MRI methods for detection of contrast agents. Here, we propose a digital simulation approach, which includes MR relaxation (R1 and R2) mapping and image co-registration. We simulated the effects of 3 nm iron oxide nanoparticles (IONPs) as a model contrast agent. Two independent relaxation maps acquired from the brain of the same subject were co-registered. The baseline subtraction between the two relaxation maps showed good agreement, demonstrating the high reproducibility of the method. Next, the second relaxation map was digitally altered (“seeded”) to simulate additional MR relaxation values corresponding to several concentrations of 3 nm IONPs in various locations. The maps of absolute differences between the first relaxation map and the digitally altered second relaxation maps were assessed for conspicuity. Results based on living mouse and human brains scanned at 9.4 T and 3.0 T respectively both indicated reliable conspicuity for signal equivalent to 0.06 mM IONP or higher. Overall, the digital simulation approach is a useful method to improve the development of MRI contrast agents and accompanying MRI methodologies.

scholarly journals Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86779-86783 ◽  
Author(s):  
M. Borges ◽  
S. Yu ◽  
A. Laromaine ◽  
A. Roig ◽  
S. Suárez-García ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Coordination Polymer ◽  
Contrast Agent ◽  
Polymer Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Agent Based ◽  
Iron Coordination ◽  
T2 Mri

A novel dual T1/T21H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.

Iron oxide nanoparticles for use as an MRI contrast agent: Pharmacokinetics and metabolism

1991 ◽  
Vol 9 (3) ◽  
pp. 275-283 ◽  
Author(s):  
D. Pouliquen ◽  
J.J. Le Jeune ◽  
R. Perdrisot ◽  
A. Ermias ◽  
P. Jallet
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast
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