scholarly journals Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging

2013 ◽  
Vol 8 (3) ◽  
pp. 220-228 ◽  
Author(s):  
Zhen Ye ◽  
Xueming Wu ◽  
Mingqian Tan ◽  
Jack Jesberger ◽  
Mark Grisworld ◽  
...  
Author(s):  
Lalit N. Goswami ◽  
Shatadru Chakravarty ◽  
Quan-Yu Cai ◽  
Erik M. Shapiro ◽  
M. Frederick Hawthorne ◽  
...  

Radiology ◽  
2006 ◽  
Vol 241 (3) ◽  
pp. 861-872 ◽  
Author(s):  
Konstantin Nikolaou ◽  
Harald Kramer ◽  
Christina Grosse ◽  
Dirk Clevert ◽  
Olaf Dietrich ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Stefan Sawall ◽  
Danielle Franke ◽  
Anne Kirchherr ◽  
Jan Beckendorf ◽  
Jan Kuntz ◽  
...  

We herein developed a micro-CT method using the innovative contrast agent ExiTron™ MyoC 8000 to longitudinally monitor cardiac processes in vivo in small animals. Experiments were performed on healthy mice and mice with myocardial infarction inflicted by ligation of the left anterior descending artery. Time-dependent signal enhancement in different tissues of healthy mice was measured and various contrast agent doses were investigated so as to determine the minimum required dose for imaging of the myocardium. Due to its ability to be taken up by healthy myocardium but not by infarct tissue, ExiTron MyoC 8000 enables detection of myocardial infarction even at a very low dose. The signal enhancement in the myocardium of infarcted mice after contrast agent injection was exploited for quantification of infarct size. The values of infarct size obtained from the imaging method were compared with those obtained from histology and showed a significant correlation (R2=0.98). Thus, the developed micro-CT method allows for monitoring of a variety of processes such as cardiac remodeling in longitudinal studies.


1981 ◽  
Vol 47 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Alan J. Tiefenbrunn ◽  
Daniel R. Biello ◽  
Edward M. Geltman ◽  
Burton E. Sobel ◽  
Barry A. Siegel ◽  
...  

Biomaterials ◽  
2012 ◽  
Vol 33 (21) ◽  
pp. 5376-5383 ◽  
Author(s):  
Guodong Zhang ◽  
Rui Zhang ◽  
Marites P. Melancon ◽  
Kelvin Wong ◽  
Jian You ◽  
...  

2014 ◽  
Vol 2 (36) ◽  
pp. 6044-6053 ◽  
Author(s):  
Yingying Ma ◽  
Jiangshan Wan ◽  
Kun Qian ◽  
Shinan Geng ◽  
Nijun He ◽  
...  

High colloid stability of highly concentrated Au nanoparticles (GNPs) for use in blood-pool imaging was achieved, using p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels.


MedChemComm ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 454-459 ◽  
Author(s):  
Stephen Thompson ◽  
Melissa E. Rodnick ◽  
Jenelle Stauff ◽  
Janna Arteaga ◽  
Timothy J. Desmond ◽  
...  

Radiolabeled erythrocytes have multiple applications in nuclear medicine, including blood pool imaging.


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