Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action

ChemMedChem ◽  
2021 ◽  
Author(s):  
Yu Zhao ◽  
Geng Xu ◽  
Xiaojia Xu ◽  
Jiansong Liu ◽  
Qi Jia ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Antitumor Properties

GOLD COMPLEXES - ANTITUMOR PROPERTIES, TARGETS AND MECHANISM OF ACTION

2018 ◽  
Vol 64 (6) ◽  
pp. 697-707 ◽  
Author(s):  
David Korman ◽  
Larisa Ostrovskaya ◽  
Vladimir Kuzmin
Keyword(s):  
Tumor Cells ◽  
Mechanism Of Action ◽  
Wide Spectrum ◽  
Acquired Resistance ◽  
Thioredoxin Reductase ◽  
Human Tumor ◽  
Gold Complexes ◽  
Antitumor Properties

Gold complexes (GC) reveal antitumor activity against xenografts of human tumors as well as against transplantable animal tumors in vivo and demonstrate cytotoxic effect against the wide spectrum of human tumor cells in vitro. GC had been effective against tumors with the acquired resistance to the platinum compounds. It is revealed the strong difference between mechanism of action of GC and platinum derivatives. Proteins, mainly thioredoxin reductase and proteasoma 26S, are the principal targets for the GC action but not for the platinum derivatives impact. Thioredoxin reductase and proteasoma 26S activity inhibition by GC leads to the development of the apoptosis mainly by the mitochondrial way in tumor cells.

Mindfulness as Mechanism of Action for Stress and Well-Being Improvements

2007 ◽  
Author(s):  
Shauna L. Shapiro ◽  
Doug Oman ◽  
Carl E. Thoresen ◽  
Thomas G. Plante ◽  
Tim Flinders
Keyword(s):  
Mechanism Of Action ◽  
Well Being

Anti-diabetic effect and mechanism of action of MaEsil (Prunus mume) extract

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
JT Hwang ◽  
HJ Yang ◽  
HJ Hur ◽  
JH Park
Keyword(s):  
Mechanism Of Action ◽  
Prunus Mume

Honaucin A, mechanism of action and role as a potential cancer prevention agent

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
L Gerwick ◽  
SJ Mascuch ◽  
G Navarro ◽  
P Boudreau ◽  
TM Carland ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Mechanism Of Action ◽  
Potential Cancer

Towards understanding the mechanism of action of mithramycin and its analogues: dimerization and DNA binding studies

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
S Weidenbach ◽  
C Hou ◽  
JM Chen ◽  
OV Tsodikov ◽  
J Rohr
Keyword(s):  
Dna Binding ◽  
Mechanism Of Action ◽  
Binding Studies ◽  
Dna Binding Studies
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