Albumin conjugates of thiosemicarbazone and imidazole‐2‐thione prochelators: Iron coordination and antiproliferative activity

ChemMedChem ◽  
2021 ◽  
Author(s):  
Yu-Shien Sung ◽  
Wangbin Wu ◽  
Megan A. Ewbank ◽  
Rachel D. Utterback ◽  
Michael T. Marty ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Iron Coordination

scholarly journals Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)

ChemMedChem ◽  
2021 ◽  
Vol 16 (18) ◽  
pp. 2731-2731
Author(s):  
Yu‐Shien Sung ◽  
Wangbin Wu ◽  
Megan A. Ewbank ◽  
Rachel D. Utterback ◽  
Michael T. Marty ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Front Cover ◽  
Iron Coordination

scholarly journals Effects of Terminal Substitution and Iron Coordination on Antiproliferative Activity of l -Proline-salicylaldehyde-Thiosemicarbazone Hybrids

2017 ◽  
Vol 2017 (40) ◽  
pp. 4773-4783 ◽  
Author(s):  
Miljan N. M. Milunović ◽  
Aliona Dobrova ◽  
Ghenadie Novitchi ◽  
Nevenka Gligorijević ◽  
Siniša Radulović ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Iron Coordination

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

In vitro and in vivo antiproliferative activity of arucanolide isolated from Calea pinnatifida

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
G Marchetti ◽  
K Silva ◽  
A Ruiz ◽  
I Sousa ◽  
S Tinti ◽  
...  
Keyword(s):  
Antiproliferative Activity

Selective antiproliferative activity of spinasterol from Physospemum verticillatum against A549 and COR-L23 cancer cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
R Tundis ◽  
B Deguin ◽  
MR Loizzo ◽  
M Bonesi ◽  
S Michel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Activity

Sesquiterpenes from Neurolaena lobata with antiproliferative activity

2017 ◽  
Author(s):  
A Vasas ◽  
I Lajter ◽  
P Forgó ◽  
N Kúsz ◽  
N Bózsity ◽  
...  
Keyword(s):  
Antiproliferative Activity

Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

2017 ◽  
Vol 68 (4) ◽  
pp. 745-747 ◽  
Author(s):  
Marius Mioc ◽  
Sorin Avram ◽  
Vasile Bercean ◽  
Mihaela Balan Porcarasu ◽  
Codruta Soica ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Vascular Endothelial ◽  
Triazole Derivative ◽  
Activity Assessment ◽  
Wide Range ◽  
Specific Receptors ◽  
Endothelial Growth Factor ◽  
Selection Of

Angiogenesis plays an important function in tumor proliferation, one of the main angiogenic promoters being the vascular endothelial growth factor (VEGF) which activates specific receptors, particularly VEGFR-2. Thus, VEGFR-2 has become an essential therapeutic target in the development of new antitumor drugs. 1,2,4-triazoles show a wide range of biological activities, including antitumor effect, which was documented by numerous reports. In the current study the selection of 5-mercapto-1,2,4-triazole structure (1H-3-styryl-5-benzylidenehydrazino-carbonyl-methylsulfanil-1,2,4-triazole, Tz3a.7) was conducted based on molecular docking that emphasized it as suitable ligand for VEGFR-2 and EGFR1 receptors. Compound Tz3a.7 was synthesized and physicochemically and biologically evaluated thus revealing a moderate antiproliferative activity against breast cancer cell line MDA-MB-231.

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