Screening of inhibitors targeting heat shock protein 47 involved in the development of idiopathic pulmonary fibrosis

ChemMedChem ◽  
2021 ◽  
Author(s):  
Daisuke Okuno ◽  
Noriho Sakamoto ◽  
Mohammed Tagod ◽  
Yoshiko Akiyama ◽  
Sakiko Moriyama ◽  
...  
Keyword(s):  
Heat Shock ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Heat Shock Protein 47

scholarly journals Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis

2013 ◽  
Vol 18 (5) ◽  
pp. 581-590 ◽  
Author(s):  
Tomoyuki Kakugawa ◽  
Shin-ichi Yokota ◽  
Yuji Ishimatsu ◽  
Tomayoshi Hayashi ◽  
Shota Nakashima ◽  
...  
Keyword(s):  
Heat Shock ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Acute Exacerbation ◽  
Heat Shock Protein 47

Increased expression of collagen-binding heat shock protein 47 in murine bleomycin-induced pneumopathy

2003 ◽  
Vol 285 (4) ◽  
pp. L957-L963 ◽  
Author(s):  
Hiroshi Ishii ◽  
Hiroshi Mukae ◽  
Tomoyuki Kakugawa ◽  
Tetsuji Iwashita ◽  
Hideyuki Kaida ◽  
...  
Keyword(s):  
Heat Shock ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Smooth Muscle Actin ◽  
Protein A ◽  
Immunohistochemical Analysis ◽  
Rt Pcr ◽  
Heat Shock Protein 47 ◽  
Positive Type ◽  
Fibrotic Process

The 47-kDa heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role during the processing and/or secretion of procollagen. Expression of HSP47 has been reported to increase in parallel with expression of collagens during the progression of various fibrosis models. The aim of the present study was to investigate the association between HSP47 expression and collagen accumulation in bleomycin (BLM)-induced murine fibrosis. We investigated the expression of HSP47 protein and mRNA using immunohistochemical analysis and semi-quantitative RT-PCR in murine BLM-induced pulmonary fibrosis. Immunohistochemical analysis showed that higher expression of HSP47 protein was present in BLM-induced pulmonary fibrosis compared with controls. HSP47 was localized predominantly in α-smooth muscle actin-positive myofibroblasts, F4/80 negative, surfactant protein-A-positive type II pneumocytes, and F4/80-positive macrophages. RT-PCR also demonstrated an increase of HSP47 mRNA expression in BLM-treated lungs. Moreover, the relative amounts of HSP47 mRNA correlated significantly with the lung hydroxyproline content as an indicator of pulmonary fibrosis in BLM-treated lungs ( r = 0.406, P <0.05). Our results suggest that these cells may play a role in the fibrotic process of BLM-treated lungs through upregulation of HSP47.

scholarly journals Patients with Idiopathic Pulmonary Fibrosis with Antibodies to Heat Shock Protein 70 Have Poor Prognoses

2013 ◽  
Vol 187 (7) ◽  
pp. 768-775 ◽  
Author(s):  
Rehan A. Kahloon ◽  
Jianmin Xue ◽  
Arpit Bhargava ◽  
Eva Csizmadia ◽  
Leo Otterbein ◽  
...  
Keyword(s):  
Heat Shock ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70

scholarly journals Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Arnoldo Aquino-Gálvez ◽  
Georgina González-Ávila ◽  
Martha Pérez-Rodríguez ◽  
Oswaldo Partida-Rodríguez ◽  
Miriam Nieves-Ramírez ◽  
...  
Keyword(s):  
Heat Shock ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Gene Polymorphisms ◽  
Mexican Patients
Sign in / Sign up

Export Citation Format

Share Document