scholarly journals Cover Feature: Evaluation of Sydnone-Based Analogues of Combretastatin A-4 Phosphate (CA4P) as Vascular Disrupting Agents for Use in Cancer Therapy (ChemMedChem 24/2018)

ChemMedChem ◽  
2018 ◽  
Vol 13 (24) ◽  
pp. 2600-2600
Author(s):  
Andrew W. Brown ◽  
Toby Holmes ◽  
Matthew Fisher ◽  
Gillian M. Tozer ◽  
Joseph P. A. Harrity ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Feature Evaluation ◽  
Vascular Disrupting

scholarly journals Evaluation of Sydnone-Based Analogues of Combretastatin A-4 Phosphate (CA4P) as Vascular Disrupting Agents for Use in Cancer Therapy

ChemMedChem ◽  
2018 ◽  
Vol 13 (24) ◽  
pp. 2618-2626 ◽  
Author(s):  
Andrew W. Brown ◽  
Toby Holmes ◽  
Matthew Fisher ◽  
Gillian M. Tozer ◽  
Joseph P. A. Harrity ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Vascular Disrupting

Vascular Disrupting Agents in Cancer Therapy

2007 ◽  
pp. 809-829 ◽  
Author(s):  
Gillian M. Tozer ◽  
Chryso Kanthou ◽  
David J. Chaplin
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Vascular Disrupting

Recent advances in vascular disrupting agents in cancer therapy

2014 ◽  
Vol 6 (13) ◽  
pp. 1485-1498 ◽  
Author(s):  
Elena Porcù ◽  
Roberta Bortolozzi ◽  
Giuseppe Basso ◽  
Giampietro Viola
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Recent Advances ◽  
Vascular Disrupting

Vascular disrupting agents in cancer therapy

2021 ◽  
Vol 891 ◽  
pp. 173692
Author(s):  
Ryszard Smolarczyk ◽  
Justyna Czapla ◽  
Magdalena Jarosz-Biej ◽  
Kyle Czerwinski ◽  
Tomasz Cichoń
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Vascular Disrupting

Update on vascular disrupting agents for cancer therapy

Therapy ◽  
2011 ◽  
Vol 8 (4) ◽  
pp. 403-413
Author(s):  
Grzegorz Korpanty ◽  
Rolf A Brekken
Keyword(s):  
Cancer Therapy ◽  
Vascular Disrupting Agents ◽  
Vascular Disrupting

Synthesis and Biological Evaluation of Aryloxazole Derivatives as Antimitotic and Vascular-Disrupting Agents for Cancer Therapy

2013 ◽  
Vol 56 (22) ◽  
pp. 9008-9018 ◽  
Author(s):  
Min Jeong Choi ◽  
Eun Sun No ◽  
Dhanaji Achyutrao Thorat ◽  
Jae Wan Jang ◽  
Hakkyun Yang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Biological Evaluation ◽  
Vascular Disrupting Agents ◽  
Synthesis And Biological Evaluation ◽  
Vascular Disrupting

scholarly journals Nanoparticle Delivered Vascular Disrupting Agents (VDAs): Use of TNF-Alpha Conjugated Gold Nanoparticles for Multimodal Cancer Therapy

2013 ◽  
Vol 10 (5) ◽  
pp. 1683-1694 ◽  
Author(s):  
Mithun M. Shenoi ◽  
Isabelle Iltis ◽  
Jeunghwan Choi ◽  
Nathan A. Koonce ◽  
Gregory J. Metzger ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Tnf Alpha ◽  
Vascular Disrupting Agents ◽  
Vascular Disrupting

scholarly journals Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

2021 ◽  
Vol 16 (4) ◽  
pp. 1934578X2110100
Author(s):  
Pham The Chinh ◽  
Pham Thi Tham ◽  
Duong Huong Quynh ◽  
Nguyen Van Tuyen ◽  
Dinh Thuy Van ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Aldol Condensation ◽  
One Pot ◽  
Aryl Group ◽  
Vascular Disrupting Agents ◽  
Benzaldehyde Derivatives ◽  
Vascular Disrupting

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), and ( Z)−3-(( Z)−4-chlorobenzylidene)−1,4-dimethyl-6-((8-methyl-4-nitroquinolin-2-yl)methylene)piperazine-2,5-dione (8) showed strong cytotoxicity against 3 of the cancer cells lines (KB, HepG2 and Lu) with IC50 values ranging from 3.04 to 10.62 µM. The quinoline-derived compounds had higher cytotoxic activity than the benzaldehyde derivatives. The successful synthesis of these derivatives offers useful information for the development of more potent vascular disrupting agents based on plinabulin.

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