Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays

Simone K. Huber; Georg Höfner; Klaus T. Wanner

doi:10.1002/cmdc.201800556

Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays

ChemMedChem ◽

10.1002/cmdc.201800556 ◽

2018 ◽

Vol 13 (23) ◽

pp. 2488-2503 ◽

Cited By ~ 2

Author(s):

Simone K. Huber ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Acetic Acid ◽

Aminobutyric Acid ◽

Library Screening ◽

Binding Assays ◽

Acid Transporter

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Front Cover: Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays (ChemMedChem 23/2018)

ChemMedChem ◽

10.1002/cmdc.201800740 ◽

2018 ◽

Vol 13 (23) ◽

pp. 2464-2464

Author(s):

Simone K. Huber ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Acetic Acid ◽

Aminobutyric Acid ◽

Library Screening ◽

Binding Assays ◽

Front Cover ◽

Acid Transporter

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Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1)

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.05.001 ◽

2019 ◽

Vol 27 (13) ◽

pp. 2753-2763

Author(s):

Simone K. Huber ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Mass Spectrometry ◽

Carboxylic Acid ◽

Aminobutyric Acid ◽

Library Screening ◽

Binding Assays ◽

Acid Transporter ◽

Potential Inhibitors

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Library Screening by Means of Mass Spectrometry (MS) Binding Assays-Exemplarily Demonstrated for a Pseudostatic Library Addressing γ-Aminobutyric Acid (GABA) Transporter 1 (GAT1)

ChemMedChem ◽

10.1002/cmdc.201200201 ◽

2012 ◽

Vol 7 (9) ◽

pp. 1678-1690 ◽

Cited By ~ 31

Author(s):

Miriam Sindelar ◽

Klaus T. Wanner

Keyword(s):

Mass Spectrometry ◽

Aminobutyric Acid ◽

Library Screening ◽

Binding Assays ◽

Gaba Transporter ◽

Gaba Transporter 1

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Development and validation of an LC-ESI-MS/MS quantification method for a potentialγ-aminobutyric acid transporter 3 (GAT3) marker and its application in preliminary MS binding assays

Biomedical Chromatography ◽

10.1002/bmc.2841 ◽

2012 ◽

Vol 27 (5) ◽

pp. 641-654 ◽

Cited By ~ 1

Author(s):

Maria Polley ◽

Georg Höfner ◽

Klaus Theodor Wanner

Keyword(s):

Aminobutyric Acid ◽

Binding Assays ◽

Esi Ms ◽

Quantification Method ◽

Acid Transporter ◽

Development And Validation

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Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.02.015 ◽

2019 ◽

Vol 27 (7) ◽

pp. 1232-1245 ◽

Cited By ~ 5

Author(s):

Felix Kern ◽

Klaus T. Wanner

Keyword(s):

Mass Spectrometry ◽

Aminobutyric Acid ◽

Binding Assays ◽

Acid Transporter

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Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

Gastroenterology ◽

10.1016/s0016-5085(01)80754-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A153-A153

Author(s):

S MIYAMOTO ◽

K KATO ◽

Y ISHII ◽

S ASAI ◽

T NAGAISHI ◽

...

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Amino Acid ◽

Amino Acid Transporter ◽

Chronic Gastric Ulcer ◽

Acid Transporter

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Anticonvulsant activity of a novel gamma-aminobutyric acid transporter subtype 1 inhibitor in mice

10.26226/morressier.5785edc6d462b80296c9945b ◽

2016 ◽

Author(s):

Adrian Podkowa

Keyword(s):

Anticonvulsant Activity ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Acid Transporter

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Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36690-5 ◽

1994 ◽

Vol 269 (20) ◽

pp. 14759-14767

Author(s):

J.L. Corey ◽

N. Davidson ◽

H.A. Lester ◽

N. Brecha ◽

M.W. Quick

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Xenopus Oocytes ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Kinase C ◽

Acid Transporter

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Correlation between Anticonvulsant Activity and Inhibitory Action on Glial γ-Aminobutyric Acid Uptake of the Highly Selective Mouse γ-Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and ItsN-Alkylated Analogs

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.102.034819 ◽

2002 ◽

Vol 302 (2) ◽

pp. 636-644 ◽

Cited By ~ 59

Author(s):

H. Steve White ◽

Alan Sarup ◽

Tina Bolvig ◽

Anders S. Kristensen ◽

Gitte Petersen ◽

...

Keyword(s):

Anticonvulsant Activity ◽

Inhibitory Action ◽

Aminobutyric Acid ◽

Acid Uptake ◽

Acid Transporter

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Structural and functional studies on the sodium- and chloride-coupled .gamma.-aminobutyric acid transporter: deglycosylation and limited proteolysis

Biochemistry ◽

10.1021/bi00435a015 ◽

1989 ◽

Vol 28 (9) ◽

pp. 3722-3728 ◽

Cited By ~ 33

Author(s):

Baruch I. Kanner ◽

Shoshi Keynan ◽

Rodica Radian

Keyword(s):

Limited Proteolysis ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Functional Studies ◽

Acid Transporter

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