An Endogenous Reactive Oxygen Species (ROS)-Activated Histone Deacetylase Inhibitor Prodrug for Cancer Chemotherapy

Somnath D. Bhagat; Usha Singh; Ram Kumar Mishra; Aasheesh Srivastava

doi:10.1002/cmdc.201800367

An Endogenous Reactive Oxygen Species (ROS)-Activated Histone Deacetylase Inhibitor Prodrug for Cancer Chemotherapy

ChemMedChem ◽

10.1002/cmdc.201800367 ◽

2018 ◽

Vol 13 (19) ◽

pp. 2073-2079 ◽

Cited By ~ 11

Author(s):

Somnath D. Bhagat ◽

Usha Singh ◽

Ram Kumar Mishra ◽

Aasheesh Srivastava

Keyword(s):

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Cancer Chemotherapy ◽

Histone Deacetylase Inhibitor ◽

Reactive Oxygen ◽

Oxygen Species ◽

Endogenous Reactive Oxygen Species ◽

Deacetylase Inhibitor

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RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells

Oncogene ◽

10.1038/onc.2013.104 ◽

2013 ◽

Vol 33 (12) ◽

pp. 1527-1537 ◽

Cited By ~ 17

Author(s):

Y Zhu ◽

K Das ◽

J Wu ◽

M H Lee ◽

P Tan

Keyword(s):

Gastric Cancer ◽

Reactive Oxygen Species ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Reactive Oxygen ◽

Oxygen Species ◽

Gastric Cancer Cells ◽

Deacetylase Inhibitor ◽

Inhibitor Resistance

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PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma

journal of cancer therapeutics and research ◽

10.7243/2049-7962-2-21 ◽

2013 ◽

Vol 2 (1) ◽

pp. 21 ◽

Cited By ~ 18

Author(s):

Giselle Saulnier Sholler ◽

Erika A Currier ◽

Akshita Dutta ◽

Marni A Slavik ◽

Sharon A Illenye ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Reactive Oxygen ◽

Oxygen Species ◽

Deacetylase Inhibitor

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Abrogation of MAPK and Akt Signaling by AEE788 Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis through Reactive Oxygen Species Generation

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-1751 ◽

2007 ◽

Vol 13 (4) ◽

pp. 1140-1148 ◽

Cited By ~ 61

Author(s):

C. Yu ◽

B. B. Friday ◽

J.-P. Lai ◽

A. McCollum ◽

P. Atadja ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Reactive Oxygen Species Generation ◽

Reactive Oxygen ◽

Akt Signaling ◽

Oxygen Species ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

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Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-08-0385 ◽

2008 ◽

Vol 7 (10) ◽

pp. 3285-3297 ◽

Cited By ~ 71

Author(s):

Roberto R. Rosato ◽

Jorge A. Almenara ◽

Sonia C. Maggio ◽

Stefanie Coe ◽

Peter Atadja ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Dna Damage ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Reactive Oxygen ◽

Oxygen Species ◽

Deacetylase Inhibitor

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Proteasome inhibition sensitizes non–small cell lung cancer to histone deacetylase inhibitor–induced apoptosis through the generation of reactive oxygen species

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/s0022-5223(04)00985-7 ◽

2004 ◽

Vol 128 (5) ◽

pp. 740-748 ◽

Cited By ~ 12

Author(s):

C DENLINGER ◽

B RUNDALL ◽

D JONES

Keyword(s):

Lung Cancer ◽

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Proteasome Inhibition ◽

Small Cell ◽

Oxygen Species ◽

Small Cell Lung ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

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A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells

Biomolecules & Therapeutics ◽

10.4062/biomolther.2019.074 ◽

2020 ◽

Vol 28 (2) ◽

pp. 184-194 ◽

Cited By ~ 4

Author(s):

Sachan Richa ◽

Prasanta Dey ◽

Chaeun Park ◽

Jungho Yang ◽

Ji Yeon Son ◽

...

Keyword(s):

Prostate Cancer ◽

Reactive Oxygen Species ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Human Prostate ◽

Oxygen Species ◽

Human Prostate Cancer ◽

Prostate Cancer Cells ◽

Deacetylase Inhibitor

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Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-009-0608-2 ◽

2009 ◽

Vol 135 (11) ◽

pp. 1601-1613 ◽

Cited By ~ 20

Author(s):

Shambhunath Choudhary ◽

Hwa-Chain Robert Wang

Keyword(s):

Reactive Oxygen Species ◽

Bladder Cancer ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Oxygen Species ◽

Human Bladder Cancer ◽

Human Bladder ◽

Human Bladder Cancer Cell ◽

Deacetylase Inhibitor

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Proteasome inhibition sensitizes non–small cell lung cancer to histone deacetylase inhibitor–induced apoptosis through the generation of reactive oxygen species

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2004.07.010 ◽

2004 ◽

Vol 128 (5) ◽

pp. 740-748 ◽

Cited By ~ 43

Author(s):

Chadrick E. Denlinger ◽

Brian K. Rundall ◽

David R. Jones

Keyword(s):

Lung Cancer ◽

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Proteasome Inhibition ◽

Small Cell ◽

Oxygen Species ◽

Small Cell Lung ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

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Sodium Valproate, a Histone Deacetylase Inhibitor, Provokes Reactive Oxygen Species–Mediated Cytotoxicity in Human Hepatocellular Carcinoma Cells

Journal of Gastrointestinal Cancer ◽

10.1007/s12029-020-00370-7 ◽

2020 ◽

Cited By ~ 2

Author(s):

Prabakaran Rithanya ◽

Devaraj Ezhilarasan

Keyword(s):

Hepatocellular Carcinoma ◽

Reactive Oxygen Species ◽

Histone Deacetylase ◽

Sodium Valproate ◽

Histone Deacetylase Inhibitor ◽

Carcinoma Cells ◽

Oxygen Species ◽

Hepatocellular Carcinoma Cells ◽

Deacetylase Inhibitor ◽

Human Hepatocellular Carcinoma Cells

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Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2014.12.023 ◽

2015 ◽

Vol 69 ◽

pp. 337-344 ◽

Cited By ~ 20

Author(s):

Selvaraju Karthik ◽

Renu Sankar ◽

Krishnamoorthy Varunkumar ◽

Chidambaram Anusha ◽

Vilwanathan Ravikumar

Keyword(s):

Lung Cancer ◽

Reactive Oxygen Species ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Small Cell ◽

Oxygen Species ◽

Small Cell Lung ◽

Deacetylase Inhibitor ◽

Extrinsic Apoptosis

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