Design, Synthesis, and Biological Evaluation of Bivalent Ligands Targeting Dopamine D2
-Like Receptors and the μ-Opioid Receptor

Mingcheng Qian; Lakshmi Vasudevan; Jelle Huysentruyt; Martijn D. P. Risseeuw; Christophe Stove; Patrick M. L. Vanderheyden; Kathleen Van Craenenbroeck; Serge Van Calenbergh

doi:10.1002/cmdc.201700787

Design, Synthesis, and Biological Evaluation of Bivalent Ligands Targeting Dopamine D2 -Like Receptors and the μ-Opioid Receptor

ChemMedChem ◽

10.1002/cmdc.201700787 ◽

2018 ◽

Vol 13 (9) ◽

pp. 944-956 ◽

Cited By ~ 10

Author(s):

Mingcheng Qian ◽

Lakshmi Vasudevan ◽

Jelle Huysentruyt ◽

Martijn D. P. Risseeuw ◽

Christophe Stove ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Bivalent Ligands ◽

Design Synthesis ◽

Dopamine D2 ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Novel Bifunctional C-Terminal-Modified Peptides for δ/μ Opioid Receptor Agonists and Neurokinin-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm061369n ◽

2007 ◽

Vol 50 (12) ◽

pp. 2779-2786 ◽

Cited By ~ 40

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Peg Davis ◽

Shou-wu Ma ◽

Edita Navratilova ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Neurokinin 1 Receptor ◽

Modified Peptides ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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Corrections to Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm9016224 ◽

2009 ◽

Vol 52 (24) ◽

pp. 8057-8057 ◽

Cited By ~ 1

Author(s):

Guo Li ◽

Lindsey C. Aschenbach ◽

Jianyang Chen ◽

Michael P. Cassidy ◽

David L. Stevens ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Selective Antagonists ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm801272c ◽

2009 ◽

Vol 52 (5) ◽

pp. 1416-1427 ◽

Cited By ~ 50

Author(s):

Guo Li ◽

Lindsey C. Aschenbach ◽

Jianyang Chen ◽

Michael P. Cassidy ◽

David L. Stevens ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Selective Antagonists ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

Acta Pharmacologica Sinica ◽

10.1038/aps.2014.171 ◽

2015 ◽

Vol 36 (7) ◽

pp. 887-894 ◽

Cited By ~ 5

Author(s):

Qing Shen ◽

Yuan-yuan Qian ◽

Xue-jun Xu ◽

Wei Li ◽

Jing-gen Liu ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Ligands ◽

Design Synthesis ◽

Opioid Receptor Ligands ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective μ Opioid Receptor Agents

Journal of Medicinal Chemistry ◽

10.1021/jm301247n ◽

2012 ◽

Vol 55 (22) ◽

pp. 10118-10129 ◽

Cited By ~ 13

Author(s):

Yunyun Yuan ◽

Orgil Elbegdorj ◽

Jianyang Chen ◽

Shashidhar K. Akubathini ◽

Feng Zhang ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel μ opioid receptor ligands

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)00034-2 ◽

2000 ◽

Vol 10 (6) ◽

pp. 523-526 ◽

Cited By ~ 9

Author(s):

Martin P. Allen ◽

James F. Blake ◽

Dianne K. Bryce ◽

Mary E. Haggan ◽

Spiros Liras ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Ligands ◽

Design Synthesis ◽

Opioid Receptor Ligands ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Design, Synthesis, and Biological Evaluation of 3-Amino-3-phenylpropionamide Derivatives as Novel μ Opioid Receptor Ligands.

ChemInform ◽

10.1002/chin.200028087 ◽

2010 ◽

Vol 31 (28) ◽

pp. no-no

Author(s):

Martin P. Allen ◽

James F. Blake ◽

Dianne K. Bryce ◽

Mary E. Haggan ◽

Spiros Liras ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Ligands ◽

Design Synthesis ◽

Opioid Receptor Ligands ◽

Μ Opioid Receptor ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.05.002 ◽

2016 ◽

Vol 24 (13) ◽

pp. 2964-2970 ◽

Cited By ~ 7

Author(s):

Ting Guo ◽

Zongjie Gan ◽

Jie Chen ◽

Dechuan Wang ◽

Ling He ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Receptor Agonists ◽

Opioid Receptor Agonists ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127236 ◽

2020 ◽

Vol 30 (13) ◽

pp. 127236

Author(s):

Guangchao He ◽

Qiao Song ◽

Junwei Wang ◽

Anhua Xu ◽

Kewen Peng ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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2-Phenylcyclopropylmethylamine Derivatives as Dopamine D2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01327 ◽

2021 ◽

Author(s):

Wenzhong Yan ◽

Luyu Fan ◽

Jing Yu ◽

Ruiquan Liu ◽

Huan Wang ◽

...

Keyword(s):

Dopamine D2 Receptor ◽

D2 Receptor ◽

Biological Evaluation ◽

Design Synthesis ◽

Partial Agonists ◽

Dopamine D2 ◽

Synthesis And Biological Evaluation

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