Synthesis and Biological Evaluation of Glycyrrhetic Acid Derivatives as Potential VEGFR2 Inhibitors

ChemMedChem ◽  
2017 ◽  
Vol 12 (13) ◽  
pp. 1087-1096 ◽  
Author(s):  
Tian-Long Yan ◽  
Li-Fei Bai ◽  
Hai-Liang Zhu ◽  
Wei-Ming Zhang ◽  
Peng-Cheng Lv
Keyword(s):  
Biological Evaluation ◽  
Glycyrrhetic Acid ◽  
Synthesis And Biological Evaluation

3-(2,6-Dichloro-benzyloxy)-11-oxo-olean-12-ene-29-oic acid, a semisynthetic derivative of glycyrrhetic acid: synthesis, antiproliferative, apoptotic and anti-angiogenesis activity

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 564-575 ◽  
Author(s):  
Rajni Sharma ◽  
Santosh K. Guru ◽  
Shreyans K. Jain ◽  
Anup Singh Pathania ◽  
Ram A. Vishwakarma ◽  
...  
Keyword(s):  
Acid Synthesis ◽  
Biological Evaluation ◽  
Glycyrrhetic Acid ◽  
Semisynthetic Derivative ◽  
Synthesis And Biological Evaluation

The synthesis and biological evaluation of the semisynthetic analogs of glycyrrhetic acid are described.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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