Design and Synthesis of C3-Substituted β-Carboline-Based Histone Deacetylase Inhibitors with Potent Antitumor Activities

ChemMedChem ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. 646-651 ◽  
Author(s):  
Yong Ling ◽  
Jiao Feng ◽  
Lin Luo ◽  
Jing Guo ◽  
Yanfu Peng ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Antitumor Activities ◽  
Design And Synthesis

scholarly journals Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-PlasmodiumActivity

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1627-1636 ◽  
Author(s):  
Katharina Stenzel ◽  
Ming Jang Chua ◽  
Sandra Duffy ◽  
Yevgeniya Antonova-Koch ◽  
Stephan Meister ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Terephthalic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis ◽  
Dual Stage

scholarly journals Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities

MedChemComm ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 1828-1837 ◽  
Author(s):  
Di Ge ◽  
Lina Han ◽  
Feifei Yang ◽  
Na Zhao ◽  
Yang Yang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Hdac Inhibitors ◽  
Antitumor Activities ◽  
Aromatic Amide

Previously, we designed and synthesized a series of bis-substituted aromatic amide-based histone deacetylase (HDAC) inhibitors.

scholarly journals Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Antitumor Activities

ChemMedChem ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 638-648 ◽  
Author(s):  
Lei Zhang ◽  
Yingjie Zhang ◽  
C. James Chou ◽  
Elizabeth S. Inks ◽  
Xuejian Wang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Antitumor Activities ◽  
Enzymatic Inhibition

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors

2008 ◽  
Vol 18 (3) ◽  
pp. 1067-1071 ◽  
Author(s):  
Isabelle Paquin ◽  
Stéphane Raeppel ◽  
Silvana Leit ◽  
Frédéric Gaudette ◽  
Nancy Zhou ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis

scholarly journals Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA

2011 ◽  
Vol 8 (3) ◽  
pp. 1394-1400
Author(s):  
Lynda Ekou ◽  
Tchirioua Ekou ◽  
Javier Garcia ◽  
Isabelle Opalinski ◽  
Jean Pierre Gesson
Keyword(s):  
Small Molecules ◽  
Histone Deacetylase ◽  
Histone Deacetylases ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Suberoylanilide Hydroxamic Acid ◽  
Considerable Potential ◽  
Design And Synthesis

Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

2005 ◽  
Vol 13 (13) ◽  
pp. 4332-4342 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Azusa Matsuura ◽  
Akiyasu Kouketsu ◽  
Shinya Hisakawa ◽  
Hidehiko Nakagawa ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis

Design and synthesis of phthalimide-type histone deacetylase inhibitors

2005 ◽  
Vol 15 (20) ◽  
pp. 4427-4431 ◽  
Author(s):  
Chihiro Shinji ◽  
Takanori Nakamura ◽  
Satoko Maeda ◽  
Minoru Yoshida ◽  
Yuichi Hashimoto ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis

RETRACTED: Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors

2014 ◽  
Vol 22 (15) ◽  
pp. 3850-3855 ◽  
Author(s):  
Md. Ashraful Hoque ◽  
Md. Nurul Islam ◽  
Md. Shahidul Islam ◽  
Tamaki Kato ◽  
Norikazu Nishino ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis ◽  
Hc Toxin

Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit

2017 ◽  
Vol 350 (3-4) ◽  
pp. 1600347 ◽  
Author(s):  
Leandro A. Alves Avelar ◽  
Jana Held ◽  
Jessica A. Engel ◽  
Parichat Sureechatchaiyan ◽  
Finn K. Hansen ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis
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