Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors

Rasala Mahesh; Vadithe Lakshma Nayak; Korrapati Suresh Babu; Syed Riyaz; Thokhir Basha Shaik; Gajjela Bharth Kumar; Prema Latha Mallipeddi; Challa Ratna Reddy; Kunta Chandra Shekar; Jedy Jose; Narayana Nagesh; Ahmed Kamal

doi:10.1002/cmdc.201600643

Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors

ChemMedChem ◽

10.1002/cmdc.201600643 ◽

2017 ◽

Vol 12 (9) ◽

pp. 678-700 ◽

Cited By ~ 2

Author(s):

Rasala Mahesh ◽

Vadithe Lakshma Nayak ◽

Korrapati Suresh Babu ◽

Syed Riyaz ◽

Thokhir Basha Shaik ◽

...

Keyword(s):

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112448 ◽

2020 ◽

Vol 200 ◽

pp. 112448 ◽

Cited By ~ 2

Author(s):

Paola Oliva ◽

Romeo Romagnoli ◽

Stefano Manfredini ◽

Andrea Brancale ◽

Salvatore Ferla ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Furan Derivatives ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors

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Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00158 ◽

2016 ◽

Vol 59 (12) ◽

pp. 5721-5739 ◽

Cited By ~ 47

Author(s):

Dong Cao ◽

Yibin Liu ◽

Wei Yan ◽

Chunyu Wang ◽

Peng Bai ◽

...

Keyword(s):

Anticancer Activity ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Substituted Coumarins

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Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors

Organic & Biomolecular Chemistry ◽

10.1039/c6ob02507b ◽

2017 ◽

Vol 15 (4) ◽

pp. 852-862 ◽

Cited By ~ 7

Author(s):

Baijiao An ◽

Shun Zhang ◽

Jun Yan ◽

Ling Huang ◽

Xingshu Li

Keyword(s):

Tubulin Polymerization ◽

In Vivo Evaluation ◽

Tubulin Polymerization Inhibitors

In this paper, a series of millepachine derivatives were synthesized and evaluated as tubulin polymerization inhibitors.

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Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112847 ◽

2020 ◽

Vol 208 ◽

pp. 112847

Author(s):

Weifeng Ma ◽

Peng Chen ◽

Xiansen Huo ◽

Yufeng Ma ◽

Yanhong Li ◽

...

Keyword(s):

Structure Activity Relationship ◽

In Vivo Study ◽

Activity Relationship ◽

Tubulin Polymerization ◽

Structure Activity ◽

Tubulin Polymerization Inhibitors

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Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111670 ◽

2019 ◽

Vol 182 ◽

pp. 111670 ◽

Cited By ~ 2

Author(s):

Yanqing Pang ◽

Haibiao Lin ◽

Caiwen Ou ◽

Yingying Cao ◽

Baijiao An ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Benzodiazepine Derivatives ◽

Synthesis And Biological Evaluation

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Faculty Opinions recommendation of A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031506.367705 ◽

2006 ◽

Author(s):

Karen Allen

Keyword(s):

Arginine Deiminase ◽

In Vivo Evaluation ◽

Design Synthesis ◽

Protein Arginine Deiminase

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New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo

Molecular Diversity ◽

10.1007/s11030-021-10236-0 ◽

2021 ◽

Author(s):

Tian-Yi Zhang ◽

Chun-Shi Li ◽

Li-Ting Cao ◽

Xue-Qian Bai ◽

Dong-Hai Zhao ◽

...

Keyword(s):

Ursolic Acid ◽

Inflammatory Activity ◽

Design Synthesis ◽

Anti Inflammatory

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Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00491 ◽

2021 ◽

Author(s):

Kalpana Tilekar ◽

Jessica D. Hess ◽

Neha Upadhyay ◽

Alessandra Lo Bianco ◽

Markus Schweipert ◽

...

Keyword(s):

Antitumor Effects ◽

Design Synthesis

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Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinoline Compounds as New Tubulin Polymerization Inhibitors

International Journal of Molecular Sciences ◽

10.3390/ijms160510173 ◽

2015 ◽

Vol 16 (12) ◽

pp. 10173-10184 ◽

Cited By ~ 1

Author(s):

Ling Zhang ◽

Yunlong Song ◽

Jingjing Huang ◽

Jia Liu ◽

Wenwen Zhu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of Novel Acridine and Quinoline Derivatives as Tubulin Polymerization Inhibitors with Anticancer Activities

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116376 ◽

2021 ◽

pp. 116376

Author(s):

Yichang Ren ◽

Yong Ruan ◽

Binbin Cheng ◽

Ling Li ◽

Jin Liu ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Polymerization ◽

Quinoline Derivatives ◽

Anticancer Activities ◽

Design Synthesis ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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