Oxidation Potentials of N-Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity

ChemMedChem ◽  
2014 ◽  
Vol 10 (2) ◽  
pp. 368-379 ◽  
Author(s):  
Christian J. Lemmerhirt ◽  
Mirko Rombach ◽  
Anja Bodtke ◽  
Patrick J. Bednarski ◽  
Andreas Link
Keyword(s):  
Oxidation Potentials ◽  
Channel Opening ◽  
Derivatives Of ◽  
Hepatocyte Toxicity

The synthesis and BK channel-opening activity of N- acylaminoalkyloxime derivatives of dehydroabietic acid

2016 ◽  
Vol 26 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Yong-Mei Cui ◽  
Xin-Lan Liu ◽  
Wen-Ming Zhang ◽  
Hai-Xia Lin ◽  
Tomohiko Ohwada ◽  
...  
Keyword(s):  
Dehydroabietic Acid ◽  
Bk Channel ◽  
Channel Opening ◽  
Derivatives Of

Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

2008 ◽  
Vol 18 (24) ◽  
pp. 6386-6389 ◽  
Author(s):  
Yong-Mei Cui ◽  
Eriko Yasutomi ◽  
Yuko Otani ◽  
Takashi Yoshinaga ◽  
Katsutoshi Ido ◽  
...  
Keyword(s):  
Bk Channel ◽  
Oxime Ether ◽  
Design Synthesis ◽  
Channel Opening ◽  
Derivatives Of

β-Nitro-substituted free-base, iron(III) and manganese(III) tetraarylporphyrins: synthesis, electrochemistry and effect of the NO2 substituent on spectra and redox potentials in non-aqueous media

2013 ◽  
Vol 17 (08n09) ◽  
pp. 857-869 ◽  
Author(s):  
Shuibo Yang ◽  
Bin Sun ◽  
Zhongping Ou ◽  
Deying Meng ◽  
Guifen Lu ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Redox Potentials ◽  
Free Base ◽  
Absorption Bands ◽  
H Nmr ◽  
Oxidation Potentials ◽  
Visible Spectra ◽  
Phenyl Rings ◽  
Metal Derivatives ◽  
Derivatives Of

Two free-base and four metal derivatives of substituted tetraarylporphyrins containing a nitro-substituent on the β-pyrrole position of the macrocycle were synthesized and characterized by UV-vis, FTIR, 1 H NMR and mass spectrometry as well as electrochemistry and spectroelectrochemistry in non-aqueous media. The porphyrins are represented as ( NO 2 TmPP ) M and ( NO 2 TdmPP ) M , where M = 2 H , Fe III Cl or Mn III Cl , m is a CH 3 group on the para-position of the four meso-phenyl rings of the tetraphenylporphyrin (TPP) and dm represents two OCH 3 substituents on the meta-positions of each phenyl ring of the TPP macrocycle. UV-visible spectra of the nitro-substituted porphyrins exhibit absorption bands which are red-shifted by 4–11 nm as compared to bands of the same substituted tetraarylporphyrins lacking a nitro substituent. Three or four reductions are observed for each iron and manganese nitroporphyrin, the first of which is metal-centered, leading to formation of an Fe ( II ) or Mn ( II ) complex. Further reduction at the metal center occurs for the iron porphyrins but this reaction proceeds via an Fe ( II ) π anion radical in the case of the two nitro-substituented derivatives. The β-nitro-substituted porphyrins are easier to reduce and harder to oxidize than the corresponding compounds lacking a nitro group. The effect of NO 2 substituent on reduction/oxidation potentials and the site of electron transfer was also discussed.

OXIDATION–REDUCTION POLYMERS: III. STANDARD OXIDATION POTENTIALS OF 2,5-DIHYDROXYDIPHENYL SULPHONES

1964 ◽  
Vol 42 (3) ◽  
pp. 554-559 ◽  
Author(s):  
I. H. Spinner ◽  
H. P. Kasserra ◽  
W. Metanomski
Keyword(s):  
Oxidation Potentials ◽  
Oxidation Reduction ◽  
Derivatives Of

The preparation of two new sulphonyl derivatives of methoxy- and naphtha-hydroquinone as possible intermediate compounds in the synthesis of redox monomers is described. The standard oxidation potentials of these and other sulphonyl derivatives of hydroquinones were determined and compared with the values for similar compounds, reported previously (1).

scholarly journals The Mechanisms of Inhibition of Frog Endplate Currents With Homologous Derivatives of the 1,1-dimethyl-3-oxybutyl Phosphonic Acid

2012 ◽  
pp. 395-404
Author(s):  
E. PRYAZHNIKOV ◽  
A. OSTROUMOV ◽  
O. DRUGININA ◽  
F. VYSKOČIL ◽  
A. SKORINKIN
Keyword(s):  
Mathematical Modeling ◽  
Phosphonic Acid ◽  
Open Channel ◽  
Allosteric Modulation ◽  
Rhythmic Stimulation ◽  
Channel Opening ◽  
Two Component ◽  
Functional Components ◽  
Derivatives Of ◽  
Receptor Channel

The mode of inhibition of endplate currents by four esters of 1,1-dimethyl-3-oxybutyl phosphonic acid with different lipophilicities and molecule lengths were estimated by mathematical modeling based on previous electrophysiological data supplemented by several experiments with rhythmic stimulation. The aim was to discriminate between their receptor and non-receptor effects. It was shown that all esters have a two-component mechanism of depression: inhibition of the receptor open channel and allosteric modulation of the receptor-channel complex. The ratio of both functional components depends on the length and lipophilicity of the esters. Short and less lipophilic esters mostly act as open channel inhibitors and the rate of inhibition substantially depends on the rate of stimulation, i. e. probability of the receptor-channel opening. As the length of the ester radicals and their lipophilicity increased, these compounds were more active as allosteric receptor inhibitors, probably hindering the function of nAChRs from the lipid annulus.

Physical Properties of TCNQ Salts with N-Methyl Derivatives of Pyridine

1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik
Keyword(s):  
Physical Properties ◽  
Methyl Derivatives ◽  
Derivatives Of
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