scholarly journals Design ofgem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation

ChemMedChem ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Arun K. Ghosh ◽  
Sofiya Yashchuk ◽  
Akira Mizuno ◽  
Nilanjana Chakraborty ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Brain Penetration ◽  
X Ray ◽  
Hiv 1

scholarly journals Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

2017 ◽  
Vol 27 (21) ◽  
pp. 4925-4931 ◽  
Author(s):  
Arun K. Ghosh ◽  
W. Sean Fyvie ◽  
Margherita Brindisi ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation

2016 ◽  
Vol 59 (14) ◽  
pp. 6826-6837 ◽  
Author(s):  
Arun K. Ghosh ◽  
Heather L. Osswald ◽  
Kristof Glauninger ◽  
Johnson Agniswamy ◽  
Yuan-Fang Wang ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Protein X ◽  
Hiv 1

scholarly journals Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

2015 ◽  
Vol 25 (21) ◽  
pp. 4903-4909 ◽  
Author(s):  
Arun K. Ghosh ◽  
Jun Takayama ◽  
Luke A. Kassekert ◽  
Jean-Rene Ella-Menye ◽  
Sofiya Yashchuk ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

2015 ◽  
Vol 13 (48) ◽  
pp. 11607-11621 ◽  
Author(s):  
Arun K. Ghosh ◽  
Cuthbert D. Martyr ◽  
Luke A. Kassekert ◽  
Prasanth R. Nyalapatla ◽  
Melinda Steffey ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed and synthesized.

scholarly journals Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir

ChemMedChem ◽  
2017 ◽  
Vol 12 (23) ◽  
pp. 1942-1952 ◽  
Author(s):  
Arun K. Ghosh ◽  
W. Sean Fyvie ◽  
Margherita Brindisi ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal Structure

2011 ◽  
Vol 54 (16) ◽  
pp. 5890-5901 ◽  
Author(s):  
Arun K. Ghosh ◽  
Bruno D. Chapsal ◽  
Garth L. Parham ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Protease Inhibitors ◽  
Biological Evaluation ◽  
X Ray ◽  
Hiv 1

scholarly journals Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies

2008 ◽  
Vol 6 (20) ◽  
pp. 3703 ◽  
Author(s):  
Arun K. Ghosh ◽  
Sandra Gemma ◽  
Jun Takayama ◽  
Abigail Baldridge ◽  
Sofiya Leshchenko-Yashchuk ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies†

2008 ◽  
Vol 51 (19) ◽  
pp. 6021-6033 ◽  
Author(s):  
Arun K. Ghosh ◽  
Sandra Gemma ◽  
Abigail Baldridge ◽  
Yuan-Fang Wang ◽  
Andrey Yu. Kovalevsky ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Cyclic Ethers ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

2017 ◽  
Vol 25 (19) ◽  
pp. 5114-5127 ◽  
Author(s):  
Arun K. Ghosh ◽  
Margherita Brindisi ◽  
Prasanth R. Nyalapatla ◽  
Jun Takayama ◽  
Jean-Rene Ella-Menye ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
X Ray ◽  
Hiv 1
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