Antiproliferative Activity, Cell Cycle, and Apoptosis Studies of a Series of 6-Substituted 9H-Purin-9-yl-pyridinium Derivatives on a Human Cervical Carcinoma Cell Line

ChemMedChem ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. 1266-1269 ◽  
Author(s):  
Belén Rubio-Ruiz ◽  
Javier Ramos-Torrecillas ◽  
Fermín Capitán-Cañadas ◽  
Rosario Sánchez-Martín ◽  
Miguel Ángel Gallo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Cervical Carcinoma ◽  
Antiproliferative Activity ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Cervical Carcinoma ◽  
Cervical Carcinoma Cell Line

Abstract B208: Reduction in P2X7 receptor expression is a marker of resistance to ATP treatment in human cervical carcinoma cell line.

2013 ◽  
Author(s):  
Paola de Andrade Mello ◽  
Eduardo Cremonese Filippi-Chiela ◽  
Jessica Nascimento ◽  
Franciele Cristina Kipper ◽  
Aline Beckenkamp ◽  
...  
Keyword(s):  
Cell Line ◽  
Cervical Carcinoma ◽  
P2x7 Receptor ◽  
Carcinoma Cell ◽  
Receptor Expression ◽  
Carcinoma Cell Line ◽  
Human Cervical Carcinoma ◽  
Cervical Carcinoma Cell Line

scholarly journals Identification of a cancer stem cell-like side population in the HeLa human cervical carcinoma cell line

2013 ◽  
Vol 6 (6) ◽  
pp. 1673-1680 ◽  
Author(s):  
KEFANG WANG ◽  
JIANFANG ZENG ◽  
LIJING LUO ◽  
JIAXIN YANG ◽  
JIE CHEN ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Cervical Carcinoma ◽  
Carcinoma Cell ◽  
Side Population ◽  
Carcinoma Cell Line ◽  
Human Cervical Carcinoma ◽  
Cervical Carcinoma Cell Line

scholarly journals Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-κB activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa

2006 ◽  
Vol 188 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Yen-Shen Lu ◽  
Pei-Yen Yeh ◽  
Shuang-En Chuang ◽  
Ming Gao ◽  
Min-Liang Kuo ◽  
...  
Keyword(s):  
Cell Line ◽  
Cervical Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Dominant Negative ◽  
Carcinoma Cell Line ◽  
Drug Induced ◽  
Enhancing Effect ◽  
Human Cervical Carcinoma ◽  
Cervical Carcinoma Cell Line

Glucocorticoids (GCs) are commonly co-administered with cisplatin in the treatment of patients with carcinomas to prevent drug-induced allergic reaction, nausea and vomiting. Although GC receptor (GR) is ubiquitous in carcinoma cells and has been linked to signal transduction pathways pertinent to cell growth and apoptosis, little is known regarding the possible effect of GC on the chemosensitivity of carcinomas. Our previous study demonstrated that dexamethasone (DEX) enhances the cytotoxicity to cisplatin in a GR-rich human cervical carcinoma cell line, SiHa. In this study, we found that this cisplatin cytotoxicity-enhancing effect of DEX correlated well with its effect on abrogating the cisplatin-induced activation of nuclear factor kappa B (NF-κB). RU486, a structural homologue of DEX, partially reversed this cytotoxicity-enhancing effect of DEX, a finding consistent with the well-known partial reversing effect of RU486 on DEX-induced NF-κB suppression. Furthermore, expression of a dominant-negative truncated IκBα gene in SiHa cells completely abolished the cisplatin cytotoxicity-enhancing effect of DEX. Our data suggest that the specific action of DEX on GR may enhance the cytotoxicity of cisplatin in selected GR-rich cancer cells by suppressing NF-κB activation.

scholarly journals Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line

Oncogene ◽  
2002 ◽  
Vol 21 (46) ◽  
pp. 7050-7059 ◽  
Author(s):  
Jun Chen ◽  
Jieying Xiong ◽  
Hongyu Liu ◽  
Garry Chernenko ◽  
Shou-Ching Tang
Keyword(s):  
Cell Line ◽  
Cervical Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Cervical Carcinoma ◽  
Cervical Carcinoma Cell Line
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