Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate-Early 2 Protein, a Promising Target for Anti-HCMV Treatment

ChemMedChem ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. 1403-1414 ◽  
Author(s):  
Serena Massari ◽  
Beatrice Mercorelli ◽  
Luca Sancineto ◽  
Stefano Sabatini ◽  
Violetta Cecchetti ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Protein A ◽  
Immediate Early ◽  
Design Synthesis ◽  
Promising Target

scholarly journals Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts”

Viruses ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 117 ◽  
Author(s):  
Beatrice Mercorelli ◽  
Anna Luganini ◽  
Giorgio Palù ◽  
Giorgio Gribaudo ◽  
Arianna Loregian
Keyword(s):  
Human Cytomegalovirus ◽  
Natural Compound ◽  
Protein A ◽  
Drug Repurposing ◽  
Lytic Replication ◽  
Immediate Early ◽  
Flavonoid Compound

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]

scholarly journals The Human Cytomegalovirus UL35 Gene Encodes Two Proteins with Different Functions

2002 ◽  
Vol 76 (5) ◽  
pp. 2460-2468 ◽  
Author(s):  
Yingguang Liu ◽  
Bonita J. Biegalke
Keyword(s):  
Human Cytomegalovirus ◽  
Complex Structure ◽  
Protein A ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Terminal Portion ◽  
Virion Protein ◽  
Early Promoter ◽  
Major Immediate Early Promoter

ABSTRACT The human cytomegalovirus (HCMV) virion is a complex structure that contains at least 30 proteins, many of which have been identified. We determined that the HCMV UL35 gene encodes two proteins, including a previously unidentified virion protein. A 22-kDa phosphoprotein (ppUL35A) was translated from a 1.2-kb UL35 transcript by 4 h postinfection; a second phosphoprotein of 75 kDa (ppUL35) was translated from a 2.2-kb transcript predominantly late in infection. The 22-kDa protein localized to the nucleus, while the 75-kDa protein localized to the juxtanuclear compartment and was packaged into virion particles. The 22-kDa protein was identical to the COOH-terminal end of the 75-kDa protein but was not found in virions, thus defining the NH2-terminal portion of the 75-kDa protein as essential for packaging. Expression of the 22-kDa protein inhibited activation of the major immediate-early promoter by ppUL82 (pp71), suggesting that the UL35 22-kDa protein may modulate expression of the major immediate-early gene.

Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression.

1992 ◽  
Vol 66 (1) ◽  
pp. 95-105 ◽  
Author(s):  
A M Colberg-Poley ◽  
L D Santomenna ◽  
P P Harlow ◽  
P A Benfield ◽  
D J Tenney
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Regulate Gene Expression ◽  
Early Proteins ◽  
Immediate Early Proteins ◽  
Regulate Gene

scholarly journals Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion

2013 ◽  
Vol 9 (5) ◽  
pp. e1003383 ◽  
Author(s):  
Stefanie Ameres ◽  
Josef Mautner ◽  
Fabian Schlott ◽  
Michael Neuenhahn ◽  
Dirk H. Busch ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
Immediate Early ◽  
T Cell Epitope

Correlation Between Expression of Recombinant Proteins and Abundance of H3K4Me3 on the Enhancer of Human Cytomegalovirus Major Immediate-Early Promoter

2017 ◽  
Vol 59 (8) ◽  
pp. 315-322 ◽  
Author(s):  
Benjamin P. C. Soo ◽  
Julian Tay ◽  
Shirelle Ng ◽  
Steven C. L. Ho ◽  
Yuansheng Yang ◽  
...  
Keyword(s):  
Recombinant Proteins ◽  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Early Promoter ◽  
Major Immediate Early Promoter
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