scholarly journals Identification of a Small-Molecule Inhibitor of HIV-1 Assembly that Targets the Phosphatidylinositol (4,5)-bisphosphate Binding Site of the HIV-1 Matrix Protein

ChemMedChem ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Isaac Zentner ◽  
Luz-Jeannette Sierra ◽  
Ayesha K. Fraser ◽  
Lina Maciunas ◽  
Marie K. Mankowski ◽  
...  
Keyword(s):  
Binding Site ◽  
Small Molecule ◽  
Matrix Protein ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Hiv 1

scholarly journals Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function

1998 ◽  
Vol 64 (1) ◽  
pp. 6-13 ◽  
Author(s):  
O. M. Z. Howard ◽  
Thomas Korte ◽  
Nadya I. Tarasova ◽  
Michael Grimm ◽  
Jim A. Turpin ◽  
...  
Keyword(s):  
Cell Fusion ◽  
Small Molecule ◽  
Chemokine Receptor ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Hiv 1

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

2005 ◽  
Vol 7 (5) ◽  
pp. 493-500 ◽  
Author(s):  
Alan Lau ◽  
Karra M. Swinbank ◽  
Parvin S. Ahmed ◽  
Debra L. Taylor ◽  
Stephen P. Jackson ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Atm Kinase ◽  
Molecule Inhibitor ◽  
Hiv 1

Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation

2007 ◽  
Vol 74 (3) ◽  
pp. A27-A27
Author(s):  
J JIMENEZ ◽  
J CAO ◽  
L JACKSON ◽  
Q PENG ◽  
H WU ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Hiv 1

scholarly journals A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

1997 ◽  
Vol 186 (8) ◽  
pp. 1395-1400 ◽  
Author(s):  
Benjamin J. Doranz ◽  
Kathie Grovit-Ferbas ◽  
Matthew P. Sharron ◽  
Si-Hua Mao ◽  
Matthew Bidwell Goetz ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Small Molecule ◽  
Chemokine Receptor ◽  
Viral Entry ◽  
Small Molecule Inhibitor ◽  
Chemokine Receptor Cxcr4 ◽  
Mechanism Of Inhibition ◽  
Molecule Inhibitor ◽  
Immunodeficiency Virus ◽  
Hiv 1

The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell– tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (M)-tropic strains. Here we show that a small-molecule inhibitor, ALX40-4C, inhibits HIV-1 envelope (Env)-mediated membrane fusion and viral entry directly at the level of coreceptor use. ALX40-4C inhibited HIV-1 use of the coreceptor CXCR4 by T- and dual-tropic HIV-1 strains, whereas use of CCR5 by M- and dual-tropic strains was not inhibited. Dual-tropic viruses capable of using both CXCR4 and CCR5 were inhibited by ALX40-4C only when cells expressed CXCR4 alone. ALX40-4C blocked stromal-derived factor (SDF)-1α–mediated activation of CXCR4 and binding of the monoclonal antibody 12G5 to cells expressing CXCR4. Overlap of the ALX40-4C binding site with that of 12G5 and SDF implicates direct blocking of Env interactions, rather than downregulation of receptor, as the mechanism of inhibition. Thus, ALX40-4C represents a small-molecule inhibitor of HIV-1 infection that acts directly against a chemokine receptor at the level of Env-mediated membrane fusion.

A small-molecule inhibitor of HIV-1 Rev function detected by a diversity screen based on RRE-Rev interference

2018 ◽  
Vol 156 ◽  
pp. 68-77 ◽  
Author(s):  
Silvia Prado ◽  
Manuela Beltrán ◽  
Ángela Moreno ◽  
Luis M. Bedoya ◽  
José Alcamí ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Hiv 1

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

1998 ◽  
Vol 4 (1) ◽  
pp. 72-77 ◽  
Author(s):  
George A. Donzella ◽  
Dominique Schols ◽  
Steven W. Lin ◽  
José A. Esté ◽  
Kirsten A. Nagashima ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Hiv 1

scholarly journals Photochemical probe identification of a small‐molecule inhibitor binding site in Hedgehog acyltransferase (HHAT)

2021 ◽  
Author(s):  
Thomas Lanyon-Hogg ◽  
Markus Ritzefeld ◽  
Leran Zhang ◽  
Balazs Pogranyi ◽  
Milon Mondal ◽  
...  
Keyword(s):  
Binding Site ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Inhibitor Binding ◽  
Molecule Inhibitor ◽  
Hedgehog Acyltransferase
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