6-Halogenochromones Bearing Tryptamine: One-Step Access to Potent and Highly Selective Inhibitors of Breast Cancer Resistance Protein

ChemMedChem ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. 1177-1180 ◽  
Author(s):  
Glaucio Valdameri ◽  
Estelle Genoux-Bastide ◽  
Charlotte Gauthier ◽  
Basile Peres ◽  
Raphaël Terreux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Selective Inhibitors ◽  
One Step ◽  
Resistance Protein

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar

2009 ◽  
Vol 52 (4) ◽  
pp. 1190-1197 ◽  
Author(s):  
Matthias Kühnle ◽  
Michael Egger ◽  
Christine Müller ◽  
Anne Mahringer ◽  
Günther Bernhardt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Selective Inhibitors ◽  
Resistance Protein

Converting Potent Indeno[1,2-b]indole Inhibitors of Protein Kinase CK2 into Selective Inhibitors of the Breast Cancer Resistance Protein ABCG2

2014 ◽  
Vol 58 (1) ◽  
pp. 265-277 ◽  
Author(s):  
Gustavo Jabor Gozzi ◽  
Zouhair Bouaziz ◽  
Evelyn Winter ◽  
Nathalia Daflon-Yunes ◽  
Dagmar Aichele ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Breast Cancer Resistance Protein ◽  
Protein Kinase Ck2 ◽  
Cancer Resistance ◽  
Selective Inhibitors ◽  
Resistance Protein ◽  
Kinase Ck2

Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Sonali Mehendale-Munj
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Protein A ◽  
The Body ◽  
Cancer Therapies ◽  
Cancer Resistance ◽  
Lung Cancers ◽  
Resistance Protein ◽  
Atp Regulation ◽  
Treatment Procedures

: Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug re-sistance(MDR). It is known to expel many potent antineoplastic drugs, owing to its efflux function. Efflux of chemothera-peutics because of BCRP develops resistance to manydrugs, leading to failure in cancer treatment. BCRP plays an important role in physiology by protecting the organism from xenobiotics and other toxins. It is a half-transporter affiliated to theATP-binding cassette (ABC) superfamily of transporters, encoded by the gene ABCG2 and functions in response to adenosine triphosphate (ATP). Regulation of BCRP expression is critically controlled at molecular levels which help in maintaining the balance of xenobiotics and nutrients inside the body. Expression of BCRP can be found in brain, liver, lung cancers and acute myeloid leukemia (AML). Moreover, it is also expressed at high levels in stem cells and many cell lines. This frequent expression of BCRP has an impact on the treatment procedures and if not scrutinized may lead to failure of many cancer therapies.

Sign in / Sign up

Export Citation Format

Share Document