Integrated Synthetic, Pharmacological, and Computational Investigation of cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Enantiomers As Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4

Christo Christov; Patricia González-Bulnes; Fanny Malhaire; Tatyana Karabencheva; Cyril Goudet; Jean-Philippe Pin; Amadeu Llebaria; Jesús Giraldo

doi:10.1002/cmdc.201000378

Integrated Synthetic, Pharmacological, and Computational Investigation of cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic Acid Enantiomers As Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4

ChemMedChem ◽

10.1002/cmdc.201000378 ◽

2010 ◽

Vol 6 (1) ◽

pp. 131-140 ◽

Cited By ~ 8

Author(s):

Christo Christov ◽

Patricia González-Bulnes ◽

Fanny Malhaire ◽

Tatyana Karabencheva ◽

Cyril Goudet ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Computational Investigation ◽

Metabotropic Glutamate ◽

Cyclohexanecarboxylic Acid ◽

Positive Allosteric Modulators

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Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.04.042 ◽

2015 ◽

Vol 25 (11) ◽

pp. 2275-2279 ◽

Cited By ~ 8

Author(s):

Sirish K. Lakkaraju ◽

Hannah Mbatia ◽

Marie Hanscom ◽

Zaorui Zhao ◽

Junfang Wu ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Drug Metabolism and Disposition ◽

10.1124/dmd.114.061879 ◽

2015 ◽

Vol 43 (4) ◽

pp. 578-589 ◽

Cited By ~ 15

Author(s):

Xiaoliang Zhuo ◽

Xiaohua Stella Huang ◽

Andrew P. Degnan ◽

Lawrence B. Snyder ◽

Fukang Yang ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Glutathione Conjugates ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00727 ◽

2015 ◽

Vol 58 (20) ◽

pp. 7959-7971 ◽

Cited By ~ 12

Author(s):

Pedro M. Garcia-Barrantes ◽

Hyekyung P. Cho ◽

Colleen M. Niswender ◽

Frank W. Byers ◽

Charles W. Locuson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Wild Type ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series ofN-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Journal of Medicinal Chemistry ◽

10.1021/jm049400d ◽

2004 ◽

Vol 47 (24) ◽

pp. 5825-5828 ◽

Cited By ~ 127

Author(s):

Craig W. Lindsley ◽

David D. Wisnoski ◽

William H. Leister ◽

Julie A. O'Brien ◽

Wei Lemaire ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Receptor Function ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Discovery of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)

Current Topics in Medicinal Chemistry ◽

10.2174/1568026054750290 ◽

2005 ◽

Vol 5 (9) ◽

pp. 825-846 ◽

Cited By ~ 28

Author(s):

David Williams Jr. ◽

Craig Lindsley

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.12.110 ◽

2011 ◽

Vol 21 (9) ◽

pp. 2650-2654 ◽

Cited By ~ 11

Author(s):

Mu-Fa Zou ◽

Jianjing Cao ◽

Alice L. Rodriguez ◽

P. Jeffrey Conn ◽

Amy Hauck Newman

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Design And Synthesis ◽

Positive Allosteric Modulators

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Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.11.104 ◽

2009 ◽

Vol 19 (3) ◽

pp. 962-966 ◽

Cited By ~ 38

Author(s):

Richard Williams ◽

Colleen M. Niswender ◽

Qingwei Luo ◽

Uyen Le ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 2 (mGluR2)

Current Topics in Medicinal Chemistry ◽

10.2174/1568026054750281 ◽

2005 ◽

Vol 5 (9) ◽

pp. 869-884 ◽

Cited By ~ 23

Author(s):

Michael Rudd ◽

John McCauley

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Biological Psychiatry ◽

10.1016/j.biopsych.2012.09.012 ◽

2013 ◽

Vol 73 (6) ◽

pp. 501-509 ◽

Cited By ~ 71

Author(s):

Jerri M. Rook ◽

Meredith J. Noetzel ◽

Wendy A. Pouliot ◽

Thomas M. Bridges ◽

Paige N. Vinson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.08.087 ◽

2008 ◽

Vol 18 (20) ◽

pp. 5626-5630 ◽

Cited By ~ 41

Author(s):

Colleen M. Niswender ◽

Evan P. Lebois ◽

Qingwei Luo ◽

Kwangho Kim ◽

Hubert Muchalski ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

Download Full-text