The Role of Fluorine Substitution in Biphenyl Methylene Imidazole-Type CYP17 Inhibitors for the Treatment of Prostate Carcinoma

ChemMedChem ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. 899-910 ◽  
Author(s):  
Qingzhong Hu ◽  
Matthias Negri ◽  
Sureyya Olgen ◽  
Rolf W. Hartmann
2010 ◽  
Vol 43 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Arezoo Aghakhani ◽  
Rasool Hamkar ◽  
Mahmoud Parvin ◽  
Nastaran Ghavami ◽  
Mahsa Nadri ◽  
...  

2011 ◽  
Vol 29 (5) ◽  
pp. 595-605 ◽  
Author(s):  
Pasquale Martino ◽  
Vincenzo Scattoni ◽  
Andrea B. Galosi ◽  
Paolo Consonni ◽  
Carlo Trombetta ◽  
...  

2004 ◽  
Vol 100 (4) ◽  
pp. 375-377 ◽  
Author(s):  
Stephen J. Hentschel ◽  
Ehud Mendel ◽  
Sanjay Singh ◽  
Laurence D. Rhines

✓ Despite the relatively high incidence of prostate carcinoma involving the spinal column, those that are associated with spinal intradural extramedullary metastases are rare. The role of surgery for metastases to this spinal compartment is limited and palliative because presentation tends to be late in the course of the disease, particularly for prostate carcinoma. It is also considered to be part of the spectrum of leptomeningeal carcinomatosis and is associated with a high incidence of brain metastases. The authors review a rare case of prostate carcinoma metastatic to the spinal intradural extramedullary space and discuss its clinical presentation, imaging features, and surgical management.


Molecules ◽  
2016 ◽  
Vol 22 (1) ◽  
pp. 62 ◽  
Author(s):  
Ioannis Anestopoulos ◽  
Aristeidis Sfakianos ◽  
Rodrigo Franco ◽  
Katerina Chlichlia ◽  
Mihalis Panayiotidis ◽  
...  

2018 ◽  
Vol 6 (20) ◽  
pp. 5536-5541 ◽  
Author(s):  
Yun Li ◽  
Jiao-Jiao Liang ◽  
Hong-Cheng Li ◽  
Lin-Song Cui ◽  
Man-Keung Fung ◽  
...  

The fluorination on the π-bridge can obviously affect the photophysical behavior of the emitters and thus improve the device performance.


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