Overcoming Tumor Drug Resistance with High-Affinity Taxanes: A SAR Study of C2-Modified 7-Acyl-10-Deacetyl Cephalomannines

ChemMedChem ◽  
2007 ◽  
Vol 2 (5) ◽  
pp. 691-701 ◽  
Author(s):  
Chun-Gang Yang ◽  
Isabel Barasoain ◽  
Xuan Li ◽  
Ruth Matesanz ◽  
Ronghua Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
High Affinity ◽  
Tumor Drug Resistance ◽  
Sar Study

scholarly journals Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB1/CB2 Receptor Interaction

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2126
Author(s):  
Battistina Asproni ◽  
Gabriele Murineddu ◽  
Paola Corona ◽  
Gérard A. Pinna
Keyword(s):  
Neuropathic Pain ◽  
Cannabinoid Receptor ◽  
Receptor Interaction ◽  
Pharmacological Properties ◽  
Cb2 Receptor ◽  
Antiemetic Effect ◽  
High Affinity ◽  
Cb1 Antagonist ◽  
Cb2 Receptors ◽  
Sar Study

Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such properties include analgesic activity, bodyweight reduction, the antiemetic effect, the reduction of intraocular pressure and many others, which appear correlated to the affinity of cannabinoids towards CB1 and/or CB2 receptors. Within the search aiming to identify novel chemical scaffolds for cannabinoid receptor interaction, the CB1 antagonist/inverse agonist pyrazole-based derivative rimonabant has been modified, giving rise to several tricyclic pyrazole-based compounds, most of which endowed of high affinity and selectivity for CB1 or CB2 receptors. The aim of this review is to present the synthesis and summarize the SAR study of such tricyclic pyrazole-based compounds, evidencing, for some derivatives, their potential in the treatment of neuropathic pain, obesity or in the management of glaucoma.

scholarly journals Mechanistic Modeling Identifies Drug-Uptake History as Predictor of Tumor Drug Resistance and Nano-Carrier-Mediated Response

ACS Nano ◽  
2013 ◽  
Vol 7 (12) ◽  
pp. 11174-11182 ◽  
Author(s):  
Jennifer Pascal ◽  
Carlee E. Ashley ◽  
Zhihui Wang ◽  
Terisse A. Brocato ◽  
Joseph D. Butner ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mechanistic Modeling ◽  
Drug Uptake ◽  
Tumor Drug Resistance

scholarly journals Artificial microenvironment of in vitro glioblastoma cell cultures changes profile of miRNAs related to tumor drug resistance

2019 ◽  
Vol Volume 12 ◽  
pp. 3905-3918
Author(s):  
Monika Witusik-Perkowska ◽  
Magdalena Zakrzewska ◽  
Dariusz Jaskolski ◽  
Paweł P Liberski ◽  
Janusz Szemraj
Keyword(s):  
Drug Resistance ◽  
Cell Cultures ◽  
Glioblastoma Cell ◽  
Tumor Drug Resistance

Biotinylated carboxymethyl chitosan/CaCO3 hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69083-69093 ◽  
Author(s):  
Jin-Long Wu ◽  
Xiao-Yan He ◽  
Pei-Yuan Jiang ◽  
Meng-Qing Gong ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Tumor Drug Resistance ◽  
Anti Cancer ◽  
Targeted Drug

A tumor targeted nano-sized self-assembled drug delivery system could efficiently co-deliver an anti-cancer drug and a drug resistance inhibitor to tumor cells and achieve an improved therapeutic efficiency through inhibition of P-gp function.

Mechanisms of acquired tumor drug resistance

2019 ◽  
Vol 1872 (2) ◽  
pp. 188310 ◽  
Author(s):  
Svetlana N. Aleksakhina ◽  
Aniruddh Kashyap ◽  
Evgeny N. Imyanitov
Keyword(s):  
Drug Resistance ◽  
Tumor Drug Resistance
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