Dinuclear Alkylamine Platinum(II) Complexes of [1,2-Bis(4-fluorophenyl)ethylenediamine]platinum(II): Influence of Endocytosis and Copper and Organic Cation Transport Systems on Cellular Uptake

ChemMedChem ◽  
2006 ◽  
Vol 1 (5) ◽  
pp. 560-564 ◽  
Author(s):  
Timo Kapp ◽  
Stefanie Müller ◽  
Ronald Gust
Keyword(s):  
Cellular Uptake ◽  
Organic Cation ◽  
Cation Transport ◽  
Transport Systems ◽  
Organic Cation Transport

Functional Impairment of Renal Organic Cation Transport in Experimental Diabetes

2002 ◽  
Vol 90 (4) ◽  
pp. 181-186 ◽  
Author(s):  
Brett Grover ◽  
Christopher Auberger ◽  
Rangaprasad Sarangarajan ◽  
William Cacini
Keyword(s):  
Functional Impairment ◽  
Organic Cation ◽  
Experimental Diabetes ◽  
Cation Transport ◽  
Organic Cation Transport

Peritubular organic cation transport in isolated rabbit proximal tubules

1994 ◽  
Vol 266 (3) ◽  
pp. F450-F458 ◽  
Author(s):  
C. E. Groves ◽  
K. K. Evans ◽  
W. H. Dantzler ◽  
S. H. Wright
Keyword(s):  
Organic Cation ◽  
High Capacity ◽  
Organic Cation Transporter ◽  
Cation Transport ◽  
Proximal Tubules ◽  
Organic Cation Transport ◽  
Inhibitory Potency ◽  
Renal Proximal Tubules ◽  
Michaelis Constants ◽  
Maximal Capacity

The physiological characteristics of peritubular organic cation transport were examined by measuring the transport of the organic cation tetraethylammonium (TEA) in rabbit renal proximal tubule suspensions and isolated nonperfused rabbit renal proximal tubules. Peritubular organic cation transport in both single S2 segments and suspensions of isolated renal proximal tubules was found to be a high-capacity, high-affinity, carrier-mediated process. For tubule suspensions, the maximal capacity of the carrier for TEA (Jmax) and the concentration of TEA at 1/2 Jmax (Kt) (1.49 +/- 0.21 nmol.min-1.mg dry wt-1 and 131 +/- 16 microM, respectively), did not differ significantly from those measured in single S2 segments (Jmax, 1.16 +/- 0.075 nmol.min-1.mg dry wt-1; Kt, 108 +/- 10 microM). In addition, the pattern of inhibition of peritubular TEA transport by long-chain n-tetraalkylammonium compounds (n = 1-5) was both qualitatively and quantitatively similar in single S2 segments and tubule suspensions, exhibiting an increase in inhibitory potency with increasing alkyl chain length. For example, in tubule suspensions, apparent Michaelis constants for inhibition of TEA uptake ranged from 1.3 mM for tetramethylammonium (TMA) to 0.8 microM for tetrapentylammonium (TPeA). To determine whether these compounds were substrates for the peritubular organic cation transporter, their effect on the efflux of [14C]TEA from tubule suspensions was examined. A concentration of 0.5 mM of the short-chain tetraalkyls TMA or TEA increased the efflux of [14C]TEA (i.e., trans-stimulated) from tubules in suspension. The longer-chain tetraalkyls tetrapropylammonium, tetrabutylammonium, and TPeA all decreased the efflux of [14C]TEA from tubules in suspension; TPeA completely blocked efflux.(ABSTRACT TRUNCATED AT 250 WORDS)

Regulation of organic cation transport

2004 ◽  
Vol 449 (5) ◽  
pp. 423-441 ◽  
Author(s):  
Giuliano Ciarimboli ◽  
Eberhard Schlatter
Keyword(s):  
Organic Cation ◽  
Cation Transport ◽  
Organic Cation Transport

POSTNATAL DEVELOPMENT OF ORGANIC CATION TRANSPORT IN THE RAT LIVER

1998 ◽  
Vol 37 (2) ◽  
pp. 131-136 ◽  
Author(s):  
F. MARTEL ◽  
M.J. MARTINS ◽  
C. CALHAU ◽  
C. HIPÓLITO-REIS ◽  
I. AZEVEDO
Keyword(s):  
Postnatal Development ◽  
Rat Liver ◽  
Organic Cation ◽  
Cation Transport ◽  
Organic Cation Transport
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