Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoforms

1994 ◽  
Vol 29 (1) ◽  
pp. 29-45 ◽  
Author(s):  
A. S. Fanning ◽  
J. S. Wolenski ◽  
M. S. Mooseker ◽  
J. G. Izant
Keyword(s):  
Skeletal Muscle ◽  
Brush Border ◽  
Myosin Ii ◽  
Differential Regulation ◽  
Skeletal Muscle Myosin ◽  
Tropomyosin Isoforms ◽  
Myosin I ◽  
Muscle Myosin

scholarly journals The 110-kD protein-calmodulin complex of the intestinal microvillus (brush border myosin I) is a mechanoenzyme.

1989 ◽  
Vol 108 (6) ◽  
pp. 2395-2400 ◽  
Author(s):  
M S Mooseker ◽  
T R Coleman
Keyword(s):  
Skeletal Muscle ◽  
Plasma Membrane ◽  
Brush Border ◽  
Actin Filaments ◽  
Average Rate ◽  
Skeletal Muscle Myosin ◽  
Intestinal Brush Border ◽  
Myosin I ◽  
Actin Cables ◽  
Muscle Myosin

The 110-kD protein-calmodulin complex (110K-CM) of the intestinal brush border serves to laterally tether microvillar actin filaments to the plasma membrane. Results from several laboratories have demonstrated that this complex shares many enzymatic and structural properties with myosin. The mechanochemical potential of purified avian 110K-CM was assessed using the Nitella bead motility assay (Sheetz, M. P., and J. A. Spudich. 1983. Nature (Lond.). 303:31-35). Under low Ca2+ conditions, 110K-CM-coated beads bound to actin cables, but no movement was observed. Using EGTA/calcium buffers (approximately 5-10 microM free Ca2+) movement of 110K-CM-coated beads along actin cables (average rate of approximately 8 nm/s) was observed. The movement was in the same direction as that for beads coated with skeletal muscle myosin. The motile preparations of 110K-CM were shown to be free of detectable contamination by conventional brush border myosin. Based on these and other observations demonstrating the myosin-like properties of 110K-CM, we propose that this complex be named "brush border myosin I."

scholarly journals Regulatory Light Chains Fine-Tune Skeletal Muscle Myosin-II Function

2021 ◽  
Vol 120 (3) ◽  
pp. 344a
Author(s):  
Arnab Nayak ◽  
Tianbang Wang ◽  
Peter Franz ◽  
Walter Steffen ◽  
Igor Chizhov ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Ii ◽  
Light Chains ◽  
Skeletal Muscle Myosin ◽  
Regulatory Light Chains ◽  
Muscle Myosin ◽  
Fine Tune

Thermal unfolding of Acanthamoeba myosin II and skeletal muscle myosin

1996 ◽  
Vol 59 (3) ◽  
pp. 365-371 ◽  
Author(s):  
Michal Zolkiewski ◽  
M.Jolanta Redowicz ◽  
Edward D. Korn ◽  
Ann Ginsburg
Keyword(s):  
Skeletal Muscle ◽  
Myosin Ii ◽  
Thermal Unfolding ◽  
Skeletal Muscle Myosin ◽  
Muscle Myosin

A small-molecule inhibitor of skeletal muscle myosin II

2001 ◽  
Vol 4 (1) ◽  
pp. 83-88 ◽  
Author(s):  
A. Cheung ◽  
J. A. Dantzig ◽  
S. Hollingworth ◽  
S. M. Baylor ◽  
Y.E. Goldman ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Small Molecule ◽  
Myosin Ii ◽  
Small Molecule Inhibitor ◽  
Skeletal Muscle Myosin ◽  
Molecule Inhibitor ◽  
Muscle Myosin

scholarly journals X-Ray Structure Determination of the First Insect Skeletal Muscle Myosin II

2014 ◽  
Vol 106 (2) ◽  
pp. 45a
Author(s):  
James T. Caldwell ◽  
Girish Melkani ◽  
Sanford I. Bernstein ◽  
Tom Huxford
Keyword(s):  
Skeletal Muscle ◽  
Structure Determination ◽  
Myosin Ii ◽  
Skeletal Muscle Myosin ◽  
X Ray ◽  
Insect Skeletal Muscle ◽  
Muscle Myosin
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