RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation

2005 ◽  
Vol 60 (3) ◽  
pp. 140-152 ◽  
Author(s):  
Elen Griffith ◽  
Amanda S. Coutts ◽  
Donald M. Black
Keyword(s):  
Focal Adhesion ◽  
Adhesion Protein ◽  
Stress Fibre ◽  
Actin Stress Fibre ◽  
Focal Adhesion Protein

scholarly journals The focal adhesion protein Testin modulates KCNE2 potassium channel β subunit activity

Channels ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 229-238
Author(s):  
Maria Papanikolaou ◽  
Shawn M. Crump ◽  
Geoffrey W. Abbott
Keyword(s):  
Potassium Channel ◽  
Focal Adhesion ◽  
Β Subunit ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

scholarly journals The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion

Oncogene ◽  
2021 ◽  
Author(s):  
Qiuping Xu ◽  
Jingwei Zhang ◽  
Brian A. Telfer ◽  
Hao Zhang ◽  
Nisha Ali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Tumor Growth ◽  
Focal Adhesion ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Metastatic Breast ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

AbstractThere is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) is significantly dysregulated in human breast cancer. However, there is no definite understanding of the requirement of ERK5 in tumor growth and metastasis due to very limited characterization of the pathway in disease models. In this study, we report that a high level of ERK5 is a predictive marker of metastatic breast cancer. Mechanistically, our in vitro data revealed that ERK5 was critical for maintaining the invasive capability of triple-negative breast cancer (TNBC) cells through focal adhesion protein kinase (FAK) activation. Specifically, we found that phosphorylation of FAK at Tyr397 was controlled by a kinase-independent function of ERK5. Accordingly, silencing ERK5 in mammary tumor grafts impaired FAK phosphorylation at Tyr397 and suppressed TNBC cell metastasis to the lung without preventing tumor growth. Collectively, these results establish a functional relationship between ERK5 and FAK signaling in promoting malignancy. Thus, targeting the oncogenic ERK5-FAK axis represents a promising therapeutic strategy for breast cancer exhibiting aggressive clinical behavior.

scholarly journals TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

Development ◽  
2014 ◽  
Vol 141 (19) ◽  
pp. e1906-e1906
Author(s):  
P. D. Uchil ◽  
T. Pawliczek ◽  
T. D. Reynolds ◽  
S. Ding ◽  
A. Hinz ◽  
...  
Keyword(s):  
Focal Adhesion ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein

Gene ◽  
2000 ◽  
Vol 249 (1-2) ◽  
pp. 99-103 ◽  
Author(s):  
Jun'ichi Mashimo ◽  
Motoko Shibanuma ◽  
Hitoshi Satoh ◽  
Kazuhiro Chida ◽  
Kiyoshi Nose
Keyword(s):  
Focal Adhesion ◽  
Genomic Structure ◽  
Chromosomal Mapping ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

scholarly journals M2 Macrophages Mediate the Resistance of Gastric Adenocarcinoma Cells to 5-Fluorouracil through the Expression of Integrin β3, Focal Adhesion Kinase, and Cofilin

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Daniel Ngabire ◽  
Irvine Niyonizigiye ◽  
Maheshkumar Prakash Patil ◽  
Yeong-Ae Seong ◽  
Yong Bae Seo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Focal Adhesion ◽  
Gastric Cancer Cells ◽  
Ags Cells ◽  
Alternatively Activated Macrophages ◽  
Adhesion Protein ◽  
Integrin Β3 ◽  
Cancer Invasiveness ◽  
Gastric Cancer Treatment ◽  
Focal Adhesion Protein

Tumor microenvironment components dictate the growth and progression of various cancers. Tumor-associated macrophages are the most predominant cells in TME and play a major role in cancer invasiveness. Gastric cancer is one of the most common cancers in Asia, and recently, various cases of resistance to fluorouracil treatment have been reported. In this study, we investigated the role of alternatively activated macrophages in the resistance of AGS gastric cancer cells to fluorouracil. THP-1 cells were polarized using recombinant human IL-4, then were cocultured with AGS cells treated with fluorouracil. Cell viability, Western blot, immunofluorescence, and cell invasion were performed for this investigation. Our results demonstrated that polarized macrophages initiated the survival of treated AGS cells and induced the resistance in AGS by upregulating the expression of integrin β3, focal adhesion protein (FAK), and cofilin proteins. These results reveal that integrin β3, focal adhesion protein (FAK), and cofilin proteins are potential targets for the improvement of fluorouracil efficacy in gastric cancer treatment.

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