scholarly journals Nutrition Management Strategies for Nonalcoholic Fatty Liver Disease: Treatment and Prevention

2020 ◽  
Vol 15 (4) ◽  
pp. 144-148
Author(s):  
Evelyn F. Miller
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Management Strategies ◽  
Disease Treatment ◽  
Nonalcoholic Fatty Liver ◽  
Nutrition Management ◽  
Treatment And Prevention

Effects of inflammatory bowel disease treatment on the risk of nonalcoholic fatty liver disease

2018 ◽  
Vol 30 (8) ◽  
pp. 854-860 ◽  
Author(s):  
Kamolyut Lapumnuaypol ◽  
Napatt Kanjanahattakij ◽  
David Pisarcik ◽  
Charat Thongprayoon ◽  
Karn Wijarnpreecha ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Disease Treatment ◽  
Nonalcoholic Fatty Liver ◽  
Inflammatory Bowel

scholarly journals Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Chance S. Friesen ◽  
Chelsea Hosey-Cojocari ◽  
Sherwin S. Chan ◽  
Iván L. Csanaky ◽  
Jonathan B. Wagner ◽  
...  
Keyword(s):  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Weight Reduction ◽  
Fatty Liver Disease ◽  
Lifestyle Modification ◽  
Drug Repurposing ◽  
Nonalcoholic Fatty Liver ◽  
Treatment And Prevention

Obesity is the single greatest risk factor for nonalcoholic fatty liver disease (NAFLD). Without intervention, most pediatric patients with NAFLD continue to gain excessive weight, making early, effective weight loss intervention key for disease treatment and prevention of NAFLD progression. Unfortunately, outside of a closely monitored research setting, which is not representative of the real world, lifestyle modification success for weight loss in children is low. Bariatric surgery, though effective, is invasive and can worsen NAFLD postoperatively. Thus, there is an evolving and underutilized role for pharmacotherapy in children, both for weight reduction and NAFLD management. In this perspective article, we provide an overview of the efficacy of weight reduction on pediatric NAFLD treatment, discuss the pros and cons of currently approved pharmacotherapy options, as well as drugs commonly used off-label for weight reduction in children and adolescents. We also highlight gaps in, and opportunities for, streamlining obesity trials to include NAFLD assessment as a valuable, secondary, therapeutic outcome measure, which may aid drug repurposing. Finally, we describe the already available, and emerging, minimally-invasive biomarkers of NAFLD that could offer a safe and convenient alternative to liver biopsy in pediatric obesity and NAFLD trials.

scholarly journals Nonalcoholic Fatty Liver Disease in Children

2018 ◽  
Vol 38 (01) ◽  
pp. 001-013 ◽  
Author(s):  
Jake Mann ◽  
Luca Valenti ◽  
Eleonora Scorletti ◽  
Christopher Byrne ◽  
Valerio Nobili
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Pediatric Population ◽  
Management Strategies ◽  
Diagnostic Tools ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Diseases ◽  
Early Predictors

AbstractNonalcoholic steatohepatitis, a progressive form of nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children who present with particular risk factors including obesity, sedentary lifestyle, and/or a predisposing genetic background. The worldwide prevalence of NAFLD in children is a worrying phenomenon because this disease is closely associated with the development of both cirrhosis and cardiometabolic syndrome in adulthood. To date, the etiopathogenesis of primary NAFLD in children is unknown. Understanding the pathogenetic mechanisms provides the basis to characterize early predictors of the disease and noninvasive diagnostic tools and to design novel specific treatments and possible management strategies. Despite a few clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD, no treatment exists for children with NAFLD. In this review, the authors provide an overview of current concepts in epidemiology, histological features, etiopathogenesis, diagnosis, and treatment of NAFLD in pediatric population.

T1018 Management Strategies Used for Nonalcoholic Fatty Liver Disease: Survey of AASLD Members

2009 ◽  
Vol 136 (5) ◽  
pp. A-847 ◽  
Author(s):  
Anna Patel ◽  
Samer Gawrieh ◽  
Syed Rizvi ◽  
Qun Xiang ◽  
Aniko Szabo ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Management Strategies ◽  
Nonalcoholic Fatty Liver ◽  
Disease Survey
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