scholarly journals Treating hepatitis C virus in patients with decompensated cirrhosis: Why is it so difficult and does a sustained response rate rescue the patient from liver transplantation?

2015 ◽  
Vol 6 (6) ◽  
pp. 133-135 ◽  
Author(s):  
Paul Kwo ◽  
Saurabh Agrawal
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Response Rate ◽  
Sustained Response ◽  
Decompensated Cirrhosis ◽  
Sustained Response Rate

A Pilot Study: Longer Duration of Posttransplant Hepatitis C Virus Therapy May Increase the Sustained Response Rate

2009 ◽  
Vol 41 (9) ◽  
pp. 3806-3809 ◽  
Author(s):  
Z. Karasu ◽  
S. Akay ◽  
F. Yilmaz ◽  
U. Akarca ◽  
G. Ersoz ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pilot Study ◽  
Response Rate ◽  
Sustained Response ◽  
Sustained Response Rate

1219 Insulin resistance impairs sustained response rate to antiviral therapy in patients with chronic hepatitis C

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 747-747 ◽  
Author(s):  
M ROMEROGOMEZ ◽  
R CORPAS ◽  
L GRANDE ◽  
V CASTELLANOMEGIAS ◽  
M CRUZ ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Response Rate ◽  
Sustained Response ◽  
Sustained Response Rate

Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients

2005 ◽  
Vol 128 (3) ◽  
pp. 636-641 ◽  
Author(s):  
Manuel Romero-Gómez ◽  
Maria Del Mar Viloria ◽  
Raúl J. Andrade ◽  
Javier Salmerón ◽  
Moisés Diago ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Response Rate ◽  
Sustained Response ◽  
Sustained Response Rate ◽  
Chronic Hepatitis C Patients

Management of Liver Transplantation Waiting List for Decompensated Cirrhosis in a Spanish Tertiary Hospital: Differences Between Hepatitis C Virus Recipients and Other Etiologies

2014 ◽  
Vol 46 (9) ◽  
pp. 3084-3086
Author(s):  
L. Ibáñez Samaniego ◽  
M. Pérez Valderas ◽  
A. Fernández Yunquera ◽  
D. Rincón Rodríguez ◽  
J.A. López Baena ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Tertiary Hospital ◽  
Waiting List ◽  
Decompensated Cirrhosis

High sustained response rate and clearance of viremia in chronic hepatitis C after treatment with interferon-α2b for 60 weeks

Hepatology ◽  
1994 ◽  
Vol 19 (2) ◽  
pp. 280-285 ◽  
Author(s):  
Olle Reichard ◽  
Ulla Foberg ◽  
Aril Frydén ◽  
Lars Mattsson ◽  
Gunnar Norkrans ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Response Rate ◽  
Sustained Response ◽  
Sustained Response Rate ◽  
Interferon Α2b

scholarly journals PEGYLATED INTERFERON AND RIBAVIRIN FOR TREATMENT OF RECURRENT HEPATITIS C AFTER LIVER TRANSPLANTATION: a single-liver transplant center experience in Brazil

2015 ◽  
Vol 52 (3) ◽  
pp. 216-221
Author(s):  
José Huygens Parente GARCIA ◽  
Antônio Haroldo de ARAÚJO FILHO ◽  
Lucia Libanez Bessa Campelo BRAGA ◽  
Cyntia Ferreira Gomes VIANA ◽  
Tarciso Daniel Santos ROCHA ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Transplant ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Response Rate ◽  
Pegylated Interferon ◽  
Antiviral Drugs ◽  
Recipient Age

BackgroundTreatment of hepatitis C virus infection in post-transplantation patients is a challenge due to poor tolerance and low success rates.ObjectiveTo determine the response rate to pegylated interferon and ribavirin in post-liver transplant patients with hepatitis C recurrence.MethodsBetween 18 May 2002 and 18 December 2011, 601 patients underwent liver transplantation at our service (Hospital Universitário Walter Cantídio, University of Ceará), 176 (29.2%) of whom were hepatitis C virus positive. Forty received antiviral therapy and were included in this cohort study. Twenty-eight (70%) completed the treatment protocol, which consisted of pegylated interferon and ribavirin for 48 weeks.ResultsThe sustained virological response rate was 55% according to intention-to-treat analysis. Recipient age and exposure to antiviral drugs prior to liver transplantation were associated with sustained virological response in the multivariate analysis. Patients were followed for 57 months on the average. Survival at 1 and 5 years was 100% in responders, versus 100% and 78%, respectively, in non-responders.ConclusionSustained virological response rates were satisfactory in our series of liver transplantation patients, and decreased with increasing recipient age. Non-exposure to antiviral drugs prior to liver transplantation was positively associated with sustained virological response. The overall survival of responders and non-responders was similar.

Sign in / Sign up

Export Citation Format

Share Document