scholarly journals Biliary Tract Malignancies Related to Gallbladder Polyps, Primary Sclerosing Cholangitis, and Choledochal Cysts

2021 ◽  
Vol 18 (2) ◽  
pp. 85-89
Author(s):  
Hassaan A. Zia ◽  
Uzma D. Siddiqui
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Biliary Tract ◽  
Sclerosing Cholangitis ◽  
Choledochal Cysts ◽  
Gallbladder Polyps

Cholestatic Liver Injury: Care of Patients With Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

2016 ◽  
Vol 27 (4) ◽  
pp. 441-452 ◽  
Author(s):  
Laurie Larson ◽  
Michelle James ◽  
Andrea Gossard
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Disease Recurrence ◽  
Outpatient Setting ◽  
Primary Biliary Cholangitis ◽  
Malignant Neoplasms ◽  
Cholestatic Liver Disease ◽  
Gallbladder Polyps ◽  
Increased Risk ◽  
Common Causes

The most common causes of chronic cholestatic liver disease are primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Both disease processes are characterized by a destruction of intrahepatic and/or extrahepatic biliary ducts. The etiology is not entirely clear; however, there is an underlying autoimmune component contributing to both disease processes. Although PBC and PSC are often diagnosed and managed in the outpatient setting, in some instances, a patient may have jaundice, fatigue, and pruritus requiring evaluation and determination of the cholestatic cause. Patients with PSC should be monitored for evidence of cholangiocarcinoma, colon cancer, and gallbladder polyps as they are at an increased risk of malignant neoplasms. Liver transplant has the potential for improving quality of life, although disease recurrence is a risk.

In primary sclerosing cholangitis, gallbladder polyps are frequently malignant

2002 ◽  
Vol 97 (5) ◽  
pp. 1138-1142 ◽  
Author(s):  
Daniel C. Buckles ◽  
Keith D. Lindor ◽  
Nicholas F. LaRusso ◽  
Lydia M. Petrovic ◽  
Gregory J. Gores
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Gallbladder Polyps

Mo1134 Expression of Cyclooxygenase-2 in Primary Sclerosing Cholangitis: Implications for Biliary Tract Carcinogenesis

2012 ◽  
Vol 142 (5) ◽  
pp. S-603-S-604
Author(s):  
Yasutaka Ishii ◽  
Tamito Sasaki ◽  
Masahiro Serikawa ◽  
Kazuaki Chayama
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Biliary Tract ◽  
Sclerosing Cholangitis ◽  
Cyclooxygenase 2

Using CT and Cholangiography to Diagnose Biliary Tract Carcinoma Complicating Primary Sclerosing Cholangitis

2001 ◽  
Vol 177 (5) ◽  
pp. 1095-1100 ◽  
Author(s):  
William L. Campbell ◽  
Mark S. Peterson ◽  
Michael P. Federle ◽  
Eduardo S. Siqueira ◽  
Adam Slivka ◽  
...  
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Biliary Tract ◽  
Sclerosing Cholangitis ◽  
Biliary Tract Carcinoma

Choledochal Cyst Originating from Primary Sclerosing Cholangitis in a Child

2011 ◽  
Vol 96 (4) ◽  
pp. 316-319
Author(s):  
Wei-Lung Tseng ◽  
Hao-Yu Lin ◽  
Wen-Hsi Lin ◽  
Hong-Shiee Lai
Keyword(s):  
Bile Duct ◽  
Primary Sclerosing Cholangitis ◽  
Choledochal Cyst ◽  
Sclerosing Cholangitis ◽  
Extrahepatic Bile Duct ◽  
Choledochal Cysts ◽  
Type Iv ◽  
Intrahepatic Duct ◽  
Computed Tomography Image ◽  
Distended Gallbladder

Abstract Choledochal cysts are common in Asian children. Primary sclerosing cholangitis (PSC), which is characterized by inflammation and fibrosis and may lead to bile duct stricture over the intrahepatic or extrahepatic bile duct, is rare in children. Here we report a case of a 10-year-old boy who presented with a choledochal cyst originating from PSC. He had suffered from repeated abdominal pain and cholangitis for 3 years. A type IV choledochal cyst was suspected from the ultrasound and computed tomography image showing a distended gallbladder and dilatation of the bilateral intrahepatic duct at the hepatic hilar area and common bile duct (CBD). During laparotomy, a markedly distended gallbladder was noted and was shown to have no communication with the CBD by intraoperative cholangiogram. Choledochal cysts with extrahepatic and intrahepatic duct dilatation at the hilar area and marked stenosis with nearly total obstruction of the distal CBD were noted. Hepaticojejunostomy was performed. The histopathologic findings demonstrated a typical PSC picture. The patient's postoperative course was uneventful for 8 months after surgery, and he received no medication during a regular follow-up.

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