scholarly journals Association between Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 and myocardial infarction in the Chinese Han population

2006 ◽  
Vol 29 (7) ◽  
pp. 300-304 ◽  
Author(s):  
Lin Li ◽  
Long-Xian Cheng ◽  
Ripen Nsenga ◽  
Mei-An He ◽  
Tang-Chun Wu
Keyword(s):  
Myocardial Infarction ◽  
Chinese Han Population ◽  
Peroxisome Proliferator ◽  
Chinese Han ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Han Population

scholarly journals The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Meng-yun Cai ◽  
Jie Cheng ◽  
Meng-yuan Zhou ◽  
Li-li Liang ◽  
Si-min Lian ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of thrombospondin-1 gene polymorphisms with myocardial infarction in a Chinese Han population

2008 ◽  
Vol 121 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Lei GAO ◽  
Guo-ping HE ◽  
Jian DAI ◽  
Ji-zheng MA ◽  
Guo-ying YANG ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Thrombospondin 1

Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population

2004 ◽  
Vol 92 (10) ◽  
pp. 867-873 ◽  
Author(s):  
Xiaoyang Zhou ◽  
Jianfeng Huang ◽  
Jianhong Chen ◽  
Shaoyong Su ◽  
Runsheng Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Promoter Polymorphism ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Matrix Metalloproteinase 3 ◽  
Increased Risk ◽  
The Matrix

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

scholarly journals The rs3850641 polymorphism of the TNFSF4 gene increases the risk of myocardial infarction in a Chinese Han population

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Changqing Lu ◽  
Helei Jia ◽  
Aiguo Xu
Keyword(s):  
Myocardial Infarction ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Flight Mass Spectrometry ◽  
Ox40 Ligand ◽  
Atherosclerosis Development ◽  
Control Study

Tumor necrosis factor superfamily member 4 (TNFSF4), also known as Ox40 ligand (Ox40l), plays an important role in atherosclerosis development. Several studies reported the association between the rs3850641 polymorphism of the TNFSF4 gene and the risk of myocardial infarction (MI). However, the results are inconsistent. In order to explore the relationship between the rs3850641 polymorphism of the TNFSF4 gene and MI, we conducted a case–control study including 454 cases and 512 controls in a Chinese Han population. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The present study found that AA genotype (AA vs. GG: odds ratio (OR) & 95% confidence interval (CI), 2.00(1.04,3.86), P=0.039; AA vs. AG+GG: OR & 95% CI, 1.93(1.00,3.70), P=0.049) or A allele carriers (A vs. G: OR & 95% CI, 1.27(1.00,1.60), P=0.047) of the rs3850641 polymorphism of the TNFSF4 gene increased the risk of MI. In conclusion, this case–control study confirms that the rs3850641 polymorphism of the TNFSF4 gene increases the risk of MI.

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