scholarly journals The role of cardiac troponin t and other new biochemical markers in evaluation and risk stratification of patients with acute chest pain syndromes

1997 ◽  
Vol 20 (11) ◽  
pp. 934-942 ◽  
Author(s):  
B. Charles Solymoss ◽  
Martial G. Bourassa ◽  
Ewa Wesolowska ◽  
Ihor Dryda ◽  
Pierre Th$Earoux ◽  
...  
Keyword(s):  
Chest Pain ◽  
Risk Stratification ◽  
Cardiac Troponin ◽  
Biochemical Markers ◽  
Troponin T ◽  
Acute Chest Pain ◽  
Cardiac Troponin T ◽  
Pain Syndromes

scholarly journals Classification and risk stratification of patients with acute chest pain using a low discriminatory level of cardiac troponin T

2004 ◽  
Vol 27 (3) ◽  
pp. 130-136 ◽  
Author(s):  
B. Charles Solymoss ◽  
Martial G. Bourassa ◽  
Peter Cernacek ◽  
Annik Fortier ◽  
Pierre Théroux
Keyword(s):  
Chest Pain ◽  
Risk Stratification ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Acute Chest Pain ◽  
Cardiac Troponin T

scholarly journals Incremental Value of High-Sensitivity Cardiac Troponin T for Risk Prediction in Patients with Suspected Acute Myocardial Infarction

2011 ◽  
Vol 57 (9) ◽  
pp. 1318-1326 ◽  
Author(s):  
Willibald Hochholzer ◽  
Tobias Reichlin ◽  
Raphael Twerenbold ◽  
Claudia Stelzig ◽  
Kirsten Hochholzer ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chest Pain ◽  
Risk Score ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Acute Chest Pain ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Coronary Syndrome

BACKGROUND High-sensitivity cardiac troponin assays have better analytical precision and sensitivity than earlier-generation assays when measuring cardiac troponin at low concentrations. We evaluated whether use of a high-sensitivity assay could further improve risk stratification compared with a standard cardiac troponin assay. METHODS We enrolled consecutive patients presenting with acute chest pain, 30% of whom were diagnosed with acute coronary syndrome. Blood samples were drawn at the time of presentation. We measured cardiac troponin T with a standard fourth-generation assay (cTnT) and a high-sensitivity assay (hs-cTnT) (both Roche Diagnostics) and followed the patients for 24 months. RESULTS Of the 1159 patients, 76 died and 42 developed an acute myocardial infarction (AMI). Prognostic accuracy of hs-cTnT for death was significantly higher [area under ROC curve (AUC) 0.79, 95% CI 0.74–0.84] than that of cTnT (AUC 0.69, 95% CI 0.62–0.76; P < 0.001). After adjustment for Thrombolysis in Myocardial Infarction (TIMI) risk score (that included the cTnT assay result), hs-cTnT above the 99th percentile (0.014 μg/L) was associated with a hazard ratio for death of 2.60 (95% CI 1.42–4.74). Addition of hs-cTnT to the risk score improved the reclassification of patients (net reclassification improvement 0.91; 95% CI 0.67–1.14; P < 0.001). Subgroup analyses showed that this effect resulted from the better classification of patients without AMI at time of testing. hs-cTnT outperformed cTnT in the prediction of AMI during follow-up (P=0.02), but was not independently predictive for this endpoint. CONCLUSIONS Concentrations of hs-cTnT >0.014 μg/L improve the prediction of death but not subsequent AMI in unselected patients presenting with acute chest pain.

scholarly journals Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. 21-21
Author(s):  
B. Meller ◽  
L. Cullen ◽  
W. A. Parsonage ◽  
J. Greenslade ◽  
S. Aldous ◽  
...  
Keyword(s):  
Chest Pain ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Acute Chest Pain ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Diagnostic Protocol ◽  
Pain Patients
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