Is ventricular wall stress rather than left ventricular hypertrophy an important contributory factor to sudden cardiac death?

1995 ◽  
Vol 18 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Michahl A. James ◽  
Thomas J. Macconnell ◽  
John V. Jones
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Wall Stress ◽  
Left Ventricular ◽  
Contributory Factor ◽  
Ventricular Wall

Sympathetic overactivity and sudden cardiac death among hemodialysis patients with left ventricular hypertrophy

2010 ◽  
Vol 142 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Masato Nishimura ◽  
Toshiko Tokoro ◽  
Masasya Nishida ◽  
Tetsuya Hashimoto ◽  
Hiroyuki Kobayashi ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Sympathetic Overactivity

scholarly journals A new inherited syndrome causing sudden cardiac death with specific ECG changes and idiopathic left ventricular hypertrophy

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
P Swojanowsky ◽  
H Von Korn ◽  
C Basso ◽  
K Pilichou ◽  
V Stefan ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Family Members ◽  
Index Patient ◽  
Left Ventricular ◽  
Sequencing Analysis ◽  
Ecg Changes ◽  
Paternal Line

Abstract Funding Acknowledgements Type of funding sources: None. Introduction  Sudden cardiac death (SCD) is a serious threat. In individuals under the age of 35 years sudden arrhythmic death is the most frequent cause. In younger persons, genetically determined cardiac diseases (e.g., cardiomyopathies, ion-channel diseases) account for an important proportion of these cases. Purpose We discovered a unusual combination of ECG changes and left ventricular hypertrophy that lead to a cumulation of sudden cardiac death in a single family. We therefore did a scientific work-up of this finding. Methods We investigated the case of a 23 year-old male with SCD, specific ECG changes and left ventricular hypertrophy (Figure 1). Family history was significant for SCD in the paternal line. A precise analysis was performed by an international multidisciplinary expert panel including autopsy of the index patient’s heart, molecular autopsy, whole exome sequencing, analysis of the pedigree and examination of available family members (Figure 2). Results  Three cases of SCD were  reported in paternal relatives. The index patient exhibited specific ECG changes (ST-depression), which were also found in five paternal relatives and the brother of the index Patient (Figure 3). Post-mortem analysis of the heart yielded mild idiopathic concentric hypertrophy without myocardial disarray.  The genetic analysis of the index patient showed two nucleotide variations in two different genes (ANK2: c.11791G > A , MYO18B: c.3761G > A), which were also expressed in five relatives. Two family members had showed all indicators of the inherited syndrome including specific ECG changes, genetic changes and left ventricular hypertrophy. Conclusions We described a distinct inheritable syndrome causing SCD, characterized by specific ECG changes, idiopathic left ventricular hypertrophy and mutations of ANK2 and MYO18. As far as we know this is the first description of this syndrom. We hypothesize that if all features (ECG-changes, described genetic mutations, left ventricular hypertrophy) are positive, the risk for SCD may be considerably increased. Abstract Figure. ECG of index patient and pedigree

scholarly journals Left ventricular hypertrophy is associated with the risk of sudden cardiac death

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. 3684-3684
Author(s):  
J. A. Laukkanen ◽  
H. Khan ◽  
J. Karppi ◽  
S. Kurl
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Left Ventricular

Primary prevention of sudden cardiac death in hypertrophic cardiomyopathy

ESC CardioMed ◽  
2018 ◽  
pp. 2348-2351
Author(s):  
Barry J. Maron ◽  
Martin S. Maron
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Primary Prevention ◽  
Sudden Cardiac Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Intervention Selection ◽  
Initial Intervention ◽  
Subaortic Obstruction

Hypertrophic cardiomyopathy (HCM) has been regarded as the most common non-trauma-related cause of sudden cardiac death (SCD) in young people, including competitive athletes. The traditional clinical profile of HCM patients at highest risk of SCD is largely comprised of young asymptomatic patients, particularly children and adolescents. Prophylactic drug treatment to prevent SCD is ineffective and obsolete whereas the introduction of implantable cardioverter defibrillators (ICD) has changed the clinical course and natural history of the disease. The ICDs are largely responsible for reducing HCM-related mortality to 0.5%/year and have been shown to be effective despite the often complex HCM phenotype, including extreme and diverse patterns of left ventricular hypertrophy, dynamic subaortic obstruction, microvascular ischaemia, and diastolic dysfunction. An important principle related to ICD decisions in HCM patients surrounds the unpredictable nature of the arrhythmic substrate, often associated with substantial delays of 5–10 years between implant and initial intervention. Selection of patients most likely to benefit from primary prevention ICD therapy is based on non-invasive testing including echocardiography or cardiac magnetic resonance imaging, history taking, exercise testing, and ambulatory electrocardiogram (ECG). Conventional risk markers are (1) family history (one or more HCM-related SCDs in close relatives); (2) recent unexplained syncope; (3) multiple repetitive (or prolonged) non-sustained ventricular tachycardia on ambulatory ECG; (4) massive left ventricular hypertrophy (wall thickness ≥30 mm); and (5) hypotensive blood pressure response to exercise, although this is not a sole indication for ICD implants. ICD decisions within current risk stratification guidelines can be challenging, particularly in patients with just one risk factor or when available evidence is ambiguous or insufficient to assign SCD risk level with confidence.

Sign in / Sign up

Export Citation Format

Share Document