scholarly journals General concepts in the morphologic assessment of operatively excised cardiac valves-part I

1994 ◽  
Vol 17 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Bruce Waller ◽  
Jane Howard ◽  
Stephen Fess
Keyword(s):  
Cardiac Valves

scholarly journals PCR Detection of Bacteria on Cardiac Valves of Patients with Treated Bacterial Endocarditis

2005 ◽  
Vol 43 (1) ◽  
pp. 163-167 ◽  
Author(s):  
C. Rovery ◽  
G. Greub ◽  
H. Lepidi ◽  
J.-P. Casalta ◽  
G. Habib ◽  
...  
Keyword(s):  
Bacterial Endocarditis ◽  
Pcr Detection ◽  
Cardiac Valves

scholarly journals Echocardiography of cardiac valves in pericardial effusion.

Circulation ◽  
1976 ◽  
Vol 54 (3) ◽  
pp. 500-504 ◽  
Author(s):  
N C Nanda ◽  
R Gramiak ◽  
C M Gross
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Valves

Influence of stress on calcification of delipidated bovine pericardial tissue employed in construction of cardiac valves

1996 ◽  
Vol 30 (3) ◽  
pp. 411-415 ◽  
Author(s):  
E. Jorge-Herrero ◽  
P. Fern�ndez ◽  
C. Escudero ◽  
N. de la Torre ◽  
M. Zurita ◽  
...  
Keyword(s):  
Cardiac Valves

Analysis of IR spectra of mineralized deposits on human cardiac valves

2017 ◽  
Vol 43 (5) ◽  
pp. 450-452
Author(s):  
V. I. Ivanov-Omskii ◽  
S. G. Yastrebov ◽  
N. I. Gulyaev
Keyword(s):  
Ir Spectra ◽  
Cardiac Valves

Abstract MP235: PROX1 Contributes To Cardiac Valve Disease

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
YenChun Ho ◽  
Xin Geng ◽  
Rohan Varshney ◽  
Jang Kim ◽  
Sandeep Surbrahmanian ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heart Valves ◽  
Cardiac Valve ◽  
Valve Disease ◽  
Matrix Composition ◽  
Cardiac Valves ◽  
Aortic Valves ◽  
Mitral Valves ◽  
Valve Development ◽  
Cardiac Valve Disease

Background: Heart valves regulate the unidirectional forward flow and prevent retrograde backflow of blood during the cardiac cycle. Cardiac valve disease (CVD) is observed in approximately 2.5% of the general population and the incidence increases to ~10% in elderly people. Patients with severe CVD require surgery and effective pharmacological treatments are currently not available. PROX1 is a transcription factor that regulates the development of lymphatic, venous, and lymphovenous valves (vascular valves). We identified that PROX1 is also expressed in a subset of valvular endothelial cells (VECs) that are located on the downstream (fibrosa) side of cardiac valves. Whether PROX1 regulates cardiac valve development and disease is not known. Method and Results: We have discovered that mice lacking Prox1 in their VECs ( Prox1 ΔVEC ) develop enlarged aortic and mitral valves in which the expression of proteoglycans is increased (control, N=10; Prox1 ΔVEC , N=9, p <0.05). Echocardiography revealed moderate to severe stenosis of aortic valves of Prox1 ΔVEC mice (control, N=5; Prox1 ΔVEC , N=9, p <0.05). PROX1 regulates the expression of the transcription factor FOXC2 in the vascular valves. Similarly, we have found that the expression of FOXC2 is downregulated in the VECs of Prox1 ΔVEC mice. Specific knockdown of FOXC2 in VECs results in the thickening of aortic valves (control, N=10; shFoxc2 ΔVEC , N=8, p <0.05). Furthermore, restoration of FOXC2 expression in VECs ( Foxc2 OE-VEC ) ameliorates the thickening of the aortic valves of Prox1 ΔVEC mice ( Prox1 ΔVEC , N=9; Foxc2 OE-VEC ; Prox1 ΔVEC , N=8, p <0.05). We have also determined that the expression of platelet-derived growth factor-B ( Pdgfb ) is increased in the valve tissue of Prox1 ΔVEC mice and in PROX1 deficient sheep mitral valve VECs (MVECs) (siCtrl , N=4; siProx1 , N=4, p <0.05). Additionally, hyperactivation of PDGF-B signaling in mice results in a phenotype that is similar to Prox1 ΔVEC mice (control , N=4; Pdgfb GOF , N=3, p <0.05). Conclusion: Together these data suggest that PROX1 maintains the extracellular matrix composition of cardiac valves by regulating the expressions of FOXC2 and PDGF-B in VECs.

High energy phosphate depletion in leaflet matrix cells during processing of cryopreserved cardiac valves

1992 ◽  
Vol 52 (5) ◽  
pp. 483-488 ◽  
Author(s):  
Robert H. Messier ◽  
Patrick W. Domkowski ◽  
Hamdy M. Aly ◽  
Anwar S. Abd-Elfattah ◽  
Donald G. Crescenzo ◽  
...  
Keyword(s):  
High Energy ◽  
High Energy Phosphate ◽  
Cardiac Valves ◽  
Phosphate Depletion

scholarly journals Influence of UDP-Glucuronosyltransferase Polymorphisms on Stable Warfarin Doses in Patients with Mechanical Cardiac Valves

2015 ◽  
Vol 33 (6) ◽  
pp. 324-328 ◽  
Author(s):  
Sook Hee An ◽  
Byung Chul Chang ◽  
Kyung Eun Lee ◽  
Hye Sun Gwak
Keyword(s):  
Cardiac Valves ◽  
Udp Glucuronosyltransferase
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