scholarly journals Improvement in clinical outcomes of patients with heart failure and active cocaine use after β-blocker therapy

2018 ◽  
Vol 41 (4) ◽  
pp. 465-469 ◽  
Author(s):  
Persio D. Lopez ◽  
Adedoyin Akinlonu ◽  
Tuoyo O. Mene-Afejuku ◽  
Carissa Dumancas ◽  
Mohammed Saeed ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Blocker Therapy ◽  
Cocaine Use ◽  
Patients With Heart Failure ◽  
Β Blocker

Effect of β-blocker Therapy on Hospital Readmission and Mortality in Heart Failure Patients With Concurrent Cocaine Use

2018 ◽  
Vol 23 (6) ◽  
pp. 518-523 ◽  
Author(s):  
Obiora Egbuche ◽  
Ifunanya Ekechukwu ◽  
Valery Effoe ◽  
Nnamdi Maduabum ◽  
Heather R. Millard ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hospital Readmission ◽  
International Classification Of Diseases ◽  
Readmission Rates ◽  
Blocker Therapy ◽  
Cocaine Use ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure ◽  
Classification Of Diseases ◽  
Β Blocker

Background: β-Blockers are first-line agents for reduction in symptoms, hospitalization, and mortality in patients with heart failure having reduced ejection fraction (HFrEF). However, the safety and efficacy of continuous β-blocker therapy (BBT) in patients who actively use cocaine remain controversial, and available literature is limited. We aimed to evaluate the effect of BBT on hospital readmission and mortality in patients having HFrEF with concurrent cocaine use. Methods: We conducted a retrospective study of patients with a diagnosis of HFrEF between 2011 and 2014 based on International Classification of Diseases 9-Clinical Modification codes. We included patients aged 18 and older who tested positive for cocaine on a urine toxicology test obtained at the time of index admission. Patients were followed for 1 year. Multivariate logistic regression was used to assess the effect of BBT on the 30-day, all-cause and heart failure–related readmissions. Results: The 30-day readmission rates for BBT versus no BBT groups were 20% versus 41% (odds ratio [OR]: 0.17, 95% confidence interval [CI] = 0.05-0.56, P = .004) for heart failure-related readmissions and 25% versus 46% (OR: 0.19, 95% CI = 0.06-0.64, P = .007) for all-cause readmissions. Conclusion: The BBT reduced 30-day, all-cause and heart failure–related readmission rate but not 1-year mortality in patients having HFrEF with concurrent cocaine use.

Concomitant use of a positive inotropic agent to create a bridge to the successful initiation of β-blocker therapy in patients with heart failure: A proposal for a trial

2003 ◽  
Vol 145 (2) ◽  
pp. S62-S66
Author(s):  
Manuela Zampino ◽  
Christopher M. O'Connor ◽  
Wendy A. Gattis ◽  
Kirkwood F. Adams ◽  
Mihai Gheorghiade
Keyword(s):  
Heart Failure ◽  
Inotropic Agent ◽  
Blocker Therapy ◽  
Patients With Heart Failure ◽  
Β Blocker

Clinical outcomes of Β-blocker therapy in cocaine-associated heart failure

2019 ◽  
Vol 277 ◽  
pp. 153-158 ◽  
Author(s):  
Persio D. Lopez ◽  
Adedoyin Akinlonu ◽  
Tuoyo O. Mene-Afejuku ◽  
Carissa Dumancas ◽  
Mohammed Saeed ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Blocker Therapy ◽  
Β Blocker

Effects of β-Blocker Therapy on Ventilatory Responses to Exercise in Patients With Heart Failure

2005 ◽  
Vol 11 (5) ◽  
pp. 333-339 ◽  
Author(s):  
Robert Wolk ◽  
Bruce D. Johnson ◽  
Virend K. Somers ◽  
Thomas G. Allison ◽  
Ray W. Squires ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blocker Therapy ◽  
Ventilatory Responses ◽  
Patients With Heart Failure ◽  
Β Blocker

CLINICAL OUTCOMES OF β-BLOCKER THERAPY IN COCAINE-ASSOCIATED HEART FAILURE

2018 ◽  
Vol 71 (11) ◽  
pp. A886 ◽  
Author(s):  
Persio Lopez ◽  
Adedoyin Akinlonu ◽  
Tuoyo Mene-Afejuku ◽  
Carissa Dumancas ◽  
Mohammed Saeed
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Blocker Therapy ◽  
Β Blocker
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