scholarly journals Pattern of placental alkaline phosphatase ( PLAP ) expression in human tumors: a tissue microarray study on 12,381 tumors

2021 ◽  
Author(s):  
Viktor Reiswich ◽  
Natalia Gorbokon ◽  
Andreas M Luebke ◽  
Eike Burandt ◽  
Anne Menz ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Tissue Microarray ◽  
Human Tumors ◽  
Placental Alkaline Phosphatase ◽  
Microarray Study

scholarly journals Pattern of placental alkaline phosphatase (PLAP) expression in human tumours: a tissue microarray study on 12,381 tumours

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S43
Author(s):  
Viktor Reiswich ◽  
Andreas Luebke ◽  
Ria Uhlig ◽  
Sören Weidemann ◽  
Katharina Möller ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Tissue Microarray ◽  
Placental Alkaline Phosphatase ◽  
Microarray Study ◽  
Human Tumours

scholarly journals Abstract 2775: PD-L1 expression in human tumors: a tissue microarray study on 5,561 tissue samples and 87 tumor types

2021 ◽  
Author(s):  
Katharina Möller ◽  
Ronald Simon ◽  
Martina Kluth ◽  
Guido Sauter ◽  
Claudia Hube-Magg ◽  
...  
Keyword(s):  
Tissue Microarray ◽  
Human Tumors ◽  
Tissue Samples ◽  
Microarray Study ◽  
Tumor Types

scholarly journals DOG1 expression is common in human tumors: A tissue microarray study on more than 15,000 tissue samples.

2021 ◽  
pp. 153663
Author(s):  
Kristina Jansen ◽  
Nagina Farahi ◽  
Franziska Büscheck ◽  
Maximilian Lennartz ◽  
Andreas M Luebke ◽  
...  
Keyword(s):  
Tissue Microarray ◽  
Human Tumors ◽  
Tissue Samples ◽  
Microarray Study

scholarly journals GCT-06. DIAGNOSIS OF A RARE CASE OF RECURRENT GERM CELL TUMOR BY CSF PLACENTAL ALKALINE PHOSPHATASE PRESENTING WITH DIFFUSE INTRAAXIAL ABNORMALITY IN THE LOWER BRAINSTEM

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii329-iii329
Author(s):  
Hiroki Yamada ◽  
Tomohiro Abiko ◽  
Hirokazu Fujiwara ◽  
Kazunari Yoshida ◽  
Hikaru Sasaki
Keyword(s):  
Alkaline Phosphatase ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Rare Case ◽  
Cervical Spinal Cord ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Placental Alkaline Phosphatase ◽  
Steroid Pulse ◽  
Platinum Based Chemotherapy

Abstract INTRODUCTION Germ cell tumors in the central nervous system (CNS) typically arise either at suprasellar and/or pineal region, and occasionally at basal ganglia. We report a case of diagnostically challenging, recurrent germ cell tumor presented with diffuse intraaxial abnormality in and across the lower brainstem, which was diagnosed by the elevated placental alkaline phosphatase (PLAP) level in cerebrospinal fluid (CSF). CASE DESCRIPTION: A 28-year-old man had been treated by chemoradiotherapy at the previous hospital for bifocal suprasellar and pineal lesions with the provisional diagnosis of germinoma without histological confirmation. Three years later, he presented with progressive weakness of bilateral extremities for weeks. Magnetic resonance imaging showed a diffuse, bilaterally symmetric high intensity lesion on T2-weighted image with slight contrast enhancement across the ventral side of the medulla oblongata to the upper cervical spinal cord. Serum and CSF hCG, hCG-β, and AFP were all negative. Since the image findings were atypical for recurrent germ cell tumor, some kind of myelitis was initially suspected. Therefore, steroid pulse therapy was administered. However, the patient’s symptom was still gradually progressing. Then, the CSF PLAP turned out to be positive, indicating the recurrence of germinoma. Accordingly, platinum-based chemotherapy was administered, and the imaging findings, patient’s symptoms, and CSF PLAP began to improve. The patient is to be treated with radiotherapy following chemotherapy. CONCLUSION We report a rare case of CNS germ cell tumor that presented with diffuse intraaxial lesion in the lower brainstem in which examination of CSF PLAP was extremely useful.

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