scholarly journals Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

2019 ◽  
Vol 6 (1) ◽  
pp. 69-82 ◽  
Author(s):  
Hilde Ytre‐Hauge Smeland ◽  
Cecilie Askeland ◽  
Elisabeth Wik ◽  
Gøril Knutsvik ◽  
Anders Molven ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Stroma ◽  
Aggressive Tumor ◽  
Tumor Phenotypes

scholarly journals RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

Cell Cycle ◽  
2015 ◽  
Vol 14 (1) ◽  
pp. 109-122 ◽  
Author(s):  
Erik S Knudsen ◽  
A Kathleen McClendon ◽  
Jorge Franco ◽  
Adam Ertel ◽  
Paolo Fortina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Aggressive Tumor ◽  
Tumor Phenotypes

scholarly journals Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yanxia Zhan ◽  
Junxian Du ◽  
Zhihui Min ◽  
Li Ma ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Breast Cancer Cells ◽  
Hypoxic Stress ◽  
Cellular Functions ◽  
Breast Cancer Therapy ◽  
Array Analysis ◽  
Cancer Stroma ◽  
Carcinoma Associated Fibroblasts

AbstractHypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer. The circRNA array analysis was performed to screen differential expressed circRNAs between hypoxic and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their exosomes. Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic CAFs exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression. In a summary, circHIF1A from hypoxic CAFs exosomes played an important role in stem cell properties of breast cancer. CircHIF1A may act as a target molecule of breast cancer therapy.

scholarly journals Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Vidya C. Sinha ◽  
Amanda L. Rinkenbaugh ◽  
Mingchu Xu ◽  
Xinhui Zhou ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Mouse Model ◽  
Transition State ◽  
Tumor Cell ◽  
Single Cell ◽  
Tumor Cells ◽  
Breast Lesions ◽  
Aggressive Tumor ◽  
Insight Into

AbstractThere is an unmet clinical need for stratification of breast lesions as indolent or aggressive to tailor treatment. Here, single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche is characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes. Despite vast tumor cell-intrinsic differences, aggressive and indolent tumor cells are functionally indistinguishable once isolated from their local niche, suggesting a role for non-tumor collaborators in determining aggressiveness. Aggressive lesions harbor fewer total but more suppressed-like T cells, and elevated tumor-promoting neutrophils and IL-17 signaling, disruption of which increase tumor latency and reduce the number of aggressive lesions. Our study provides insight into tumor-immune features distinguishing indolent from aggressive lesions, identifies heterogeneous populations comprising these lesions, and supports a role for IL-17 signaling in aggressive progression.

Versican G1 and G3 domains are upregulated and latent transforming growth factor-β binding protein-4 is downregulated in breast cancer stroma

Breast Cancer ◽  
2011 ◽  
Vol 19 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Yuko Takahashi ◽  
Hiroko Kuwabara ◽  
Masahiko Yoneda ◽  
Zenzo Isogai ◽  
Nobuhiko Tanigawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Binding Protein ◽  
Transforming Growth Factor Β ◽  
Cancer Stroma

scholarly journals Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shilpi Gupta ◽  
Prabhat Kumar ◽  
Harsimrut Kaur ◽  
Nishi Sharma ◽  
Daman Saluja ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Tongue Cancer ◽  
Aggressive Tumor ◽  
Tumor Phenotypes

scholarly journals Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 712 ◽  
Author(s):  
Simon J. Johnston ◽  
Binafsha M. Syed ◽  
Ruth M. Parks ◽  
Cíntia J. Monteiro ◽  
Joseph A. Caruso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Older Patients ◽  
Cyclin E ◽  
Cohort Analysis ◽  
Tumor Biology ◽  
Biological Factor ◽  
Breast Cancer Specific Survival ◽  
Cancer Specific Survival ◽  
Aggressive Tumor

Multi-cohort analysis demonstrated that cytoplasmic cyclin E expression in primary breast tumors predicts aggressive disease. However, compared to their younger counterparts, older patients have favorable tumor biology and are less likely to die of breast cancer. Biomarkers therefore require interpretation in this specific context. Here, we assess data on cytoplasmic cyclin E from a UK cohort of older women alongside a panel of >20 biomarkers. Between 1973 and 2010, 813 women ≥70 years of age underwent initial surgery for early breast cancer, from which a tissue microarray was constructed (n = 517). Biomarker expression was assessed by immunohistochemistry. Multivariate analysis of breast cancer-specific survival was performed using Cox’s proportional hazards. We found that cytoplasmic cyclin E was the only biological factor independently predictive of breast cancer-specific survival in this cohort of older women (hazard ratio (HR) = 6.23, 95% confidence interval (CI) = 1.93–20.14; p = 0.002). At ten years, 42% of older patients with cytoplasmic cyclin E-positive tumors had died of breast cancer versus 8% of negative cases (p < 0.0005). We conclude that cytoplasmic cyclin E is an exquisite marker of aggressive tumor biology in older women. Patients with cytoplasmic cyclin E-negative tumors are unlikely to die of breast cancer. These data have the potential to influence treatment strategy in older patients.

scholarly journals Automated Classification of Breast Cancer Stroma Maturity From Histological Images

2017 ◽  
Vol 64 (10) ◽  
pp. 2344-2352 ◽  
Author(s):  
Sara Reis ◽  
Patrycja Gazinska ◽  
John H. Hipwell ◽  
Thomy Mertzanidou ◽  
Kalnisha Naidoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Automated Classification ◽  
Cancer Stroma ◽  
Histological Images

5163 Methylation in breast cancer and correlate ER with tumor phenotypes and prognostic factors

2009 ◽  
Vol 7 (2) ◽  
pp. 309
Author(s):  
J. Martínez-Galán ◽  
B. Torres ◽  
V. Gutierrez Calderón ◽  
G. Durán Ogalla ◽  
R. Del Moral Avila ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Tumor Phenotypes
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