Transition Metal Catalyzed Enantioselective Borylative Cyclization Reactions

2020 ◽  
Author(s):  
Yuqi Ji ◽  
Min Zhang ◽  
Mimi Xing ◽  
Huanhuan Cui ◽  
Qian Zhao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Cyclization Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals New cyclization reactions in organic syntheses

2002 ◽  
Vol 74 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Iwao Ojima
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Total Synthesis ◽  
Cyclization Reactions ◽  
Organic Syntheses ◽  
Carbocyclic Compounds ◽  
Efficient Construction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent development in the transition metal-catalyzed cyclization reactions for organic syntheses in the author's laboratories is summarized, which includes (i) novel silylcarbocyclizations (SiCaCs) and carbonylative carbotricyclizations, (ii) intramolecular silylformylations and desymmerization of siloxydiynes by sequential double silylformylation, (iii) efficient total synthesis of (+)-prosopinine, (iv) enantioselective desymmetrization of aminodienes, and (iv) new and efficient routes to 1-azabicyclo[x.y.0]alkane amino acids. All these processes are catalyzed by Rh or Rh­Co complexes, and useful for rapid and efficient construction of a variety of heterocyclic and carbocyclic compounds. Mechanisms of these new carbocyclization and cyclohydrocarbonylation reactions are also discussed.

Radical Strategy for the Transition-Metal-Catalyzed Synthesis of γ-Lactones: A Review

Synthesis ◽  
2020 ◽  
Vol 52 (24) ◽  
pp. 3855-3865
Author(s):  
Ren-Jie Song ◽  
Bin Wei ◽  
Ke-Wei Li ◽  
Yan-Chen Wu ◽  
Shi-Qi Tong
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Recent Progress ◽  
Food Additives ◽  
Radical Cyclization ◽  
Biological Molecules ◽  
Cyclization Reactions ◽  
Unsaturated Carboxylic Acids ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The γ-lactone skeleton is very important component of various natural products, biological molecules, food additives, and perfumes. As a result, much effort has been made towards such compounds. In this review, we summarize recent progress in transition-metal-catalyzed annulation reactions for the formation of γ-lactone derivatives through a radical pathway. Various reagents, such as anhydrides, Togni’s reagent, TMSN3, arenesulfonyl chlorides, arenediazonium salts, dibenzoyl peroxides, O-benzoylhydroxylamine, NFSI, and α-halocarboxylic compounds, used in radical cyclization reactions are described, and the mechanisms of these radical annulation reactions are also discussed.1 Introduction2 Annulations of Alkenes with Anhydrides3 Annulations of Unsaturated Carboxylic Acids with Nucleophiles4 Annulations of Alkenes with α-Halocarboxylic Compounds5 Conclusions and Outlook

Natural product syntheses via carbonylative cyclizations

2019 ◽  
Vol 36 (1) ◽  
pp. 174-219 ◽  
Author(s):  
Kaiqing Ma ◽  
Brandon S. Martin ◽  
Xianglin Yin ◽  
Mingji Dai
Keyword(s):  
Transition Metal ◽  
Total Synthesis ◽  
Natural Product ◽  
Cyclization Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes the application of various transition metal-catalyzed/mediated carbonylative cyclization reactions in natural product total synthesis.

Transition-Metal-Catalyzed Annulative Coupling Cascade for the Synthesis of 3-Methyleneisoindolin-1-ones

Synthesis ◽  
2020 ◽  
Vol 52 (06) ◽  
pp. 807-818 ◽  
Author(s):  
So Won Youn
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Short Review ◽  
Coupling Reactions ◽  
Cyclization Reactions ◽  
One Pot ◽  
Bond Forming ◽  
Wide Range ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This short review describes the recent progress made on transition-metal-catalyzed annulative couplings for the synthesis of 3-methyleneisoindolin-1-ones, which are useful intermediates for the synthesis of numerous alkaloids and can be often found in a wide range of natural products and pharmaceuticals. In particular, new one-pot multiple C–C/C–N bond-forming processes for the construction of the 5-methylenepyrrol-2-one nucleus of such compounds are summarized.1 Introduction2 Intramolecular Cyclization Reactions: C3–N or C3–C3a and C–C Bond Formation3 Intermolecular Annulative Coupling Reactions3.1 C3–C3a and C3–N Bond Formation3.2 C1–C7a and C3–N Bond Formation3.3 C1–C7a and C1–N Bond Formation3.4 C1–C7a, C1–N and C3–N Bond Formation3.5 C3–C3a, C1–C7a, C1–N and C3–N Bond Formation: A Pd-Catalyzed One-Pot Sonogashira Coupling–Carbonylation–Amination–Cyclization Cascade4 Conclusion

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