A Green and Highly Efficient Protocol for Catalyst-free Knoevenagel Condensation and Michael Addition of Aromatic Aldehydes with 1,3-Cyclic Diketones in PEG-400

2011 ◽  
Vol 29 (11) ◽  
pp. 2407-2410 ◽  
Author(s):  
Nemati Firouzeh ◽  
Kiani Hossein
Keyword(s):  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Peg 400 ◽  
Catalyst Free ◽  
Highly Efficient

scholarly journals Synthesis and Molecular Docking Studies of N,N-Dimethyl Arylpyranopyrimidinedione Derivatives

SynOpen ◽  
2022 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
Sivan Velmathi ◽  
Srinivasan Prabhakaran
Keyword(s):  
Molecular Docking ◽  
Reaction Mechanism ◽  
Binding Energy ◽  
Michael Addition ◽  
Barbituric Acid ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Docking Studies ◽  
Reaction Sequence ◽  
Kinesin Eg5

AbstractThe synthesis of N,N-dimethyl arylpyranopyrimidinedione derivatives from aromatic aldehydes, N-methyl-1-(methylthio)-2-nitroethamine (NMSM) and 1,3-dimethyl barbituric acid, in the presence of piperidine as a catalyst, is reported. The reaction mechanism involves a Knoevenagel condensation, followed by Michael addition and intramolecular O-cyclization reaction sequence. The synthesized compounds were docked with human kinesin Eg5 protein to calculate binding energy, inhibition constant and H-bond interaction. All the compounds show good binding affinity towards the protein, with significant docking score.

Differences between the Reaction of 2-Benzylidenecyclopentanone with Malononitrile and the Reaction of Cyclopentylidenemalononitrile with Aromatic Aldehydes; Synthesis of Strong Fluorescent o-Aminonitriles

1986 ◽  
Vol 41 (11) ◽  
pp. 1471-1478 ◽  
Author(s):  
Julian Mirek ◽  
Piotr Milart
Keyword(s):  
Michael Addition ◽  
Ring Opening ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Reactive Intermediates ◽  
Complex Reaction ◽  
Strong Fluorescence ◽  
Conjugated Triene

Abstract It was found that instead of the Knoevenagel condensation of cyclopentylidenemalononitrile with aromatic aldehydes, a complex reaction takes place leading to 5,7-dicyano-1-arylidene-4-arylindanes. The same compounds were formed in the reaction of the cyclopentylidenemalono­nitrile dimer with aldehydes. It is suggested that the cyclopentylidenem alononitrile dimers un­dergo an electrocyclic ring opening leading to conjugated triene systems. These species are very reactive intermediates and may react with aldehydes in the next step. Bulky substituents in 2,5-dibenzylidenecyclopentanone hindered its Knoevenagel condensation with malononitrile but did not hinder its Michael addition leading to a 4H -pyrane derivative. Solutions of the obtained o-aminonitriles exhibit strong fluorescence in a variety of solvents.

High-sensitivity stimuli-responsive polysiloxane synthesized via catalyst-free aza-Michael addition for ibuprofen loading and controlled release

RSC Advances ◽  
2016 ◽  
Vol 6 (101) ◽  
pp. 99414-99421 ◽  
Author(s):  
Shusheng Li ◽  
Shengyu Feng
Keyword(s):  
Controlled Release ◽  
Michael Addition ◽  
High Sensitivity ◽  
Stimuli Responsive ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient

High-sensitive stimuli-responsive polysiloxanes with high sensitive respond to three changes of thermo-, pH-, and salinity were synthesized via a facile, highly efficient, catalyst-free aza-Michael addition of poly(aminopropylmethylsiloxane) with N-isopropylacrylamide.

From LCST to UCST: the phase separation behaviour of thermo-responsive polysiloxanes with the solubility parameters of solvents

2017 ◽  
Vol 41 (5) ◽  
pp. 1997-2003 ◽  
Author(s):  
Shusheng Li ◽  
Linglong Feng ◽  
Hang Lu ◽  
Shengyu Feng
Keyword(s):  
Phase Separation ◽  
Michael Addition ◽  
Mixed Solvents ◽  
Solubility Parameters ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Type Phase

Thermo-responsive polysiloxanes with tunable LCST- and UCST-type phase separation in mixed solvents were synthesised via a facile, highly efficient, catalyst-free aza-Michael addition of poly(aminopropylmethylsiloxane) to N-isopropylacrylamide.

scholarly journals Synthesis, Characterization of Novel Benzothiophene

2021 ◽  
pp. 38-41
Author(s):  
Veerappan Jeyachandranan
Keyword(s):  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Domino Reactions ◽  
One Pot ◽  
The One

A library of novel benzo[b] thiophenehave been synthesized regioselectively in good yields through the one-pot domino reactions of thiophenone, malononitrile and aromatic aldehydes in the presence of NaOEt. This transformation presumably involves Knoevenagel condensation–Michael addition–intramolecular Thorpe-Ziegler cyclization-Tautomerization-Elimination sequence of reactions.

scholarly journals Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

2018 ◽  
Vol 14 ◽  
pp. 2907-2915 ◽  
Author(s):  
Muthumani Muthu ◽  
Rakkappan Vishnu Priya ◽  
Abdulrahman I Almansour ◽  
Raju Suresh Kumar ◽  
Raju Ranjith Kumar
Keyword(s):  
Michael Addition ◽  
Nucleophilic Addition ◽  
Ammonium Acetate ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Air Oxidation ◽  
One Pot ◽  
Tandem Process ◽  
The One

The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields.

Sign in / Sign up

Export Citation Format

Share Document