Equilibrium Studies on Reactive Extraction of α-Cyclohexyl-mandelic Enantiomers Using Hydrophilic β-Cyclodextrin Derivatives Extractants

2010 ◽  
Vol 28 (8) ◽  
pp. 1444-1450 ◽  
Author(s):  
Kewen Tang ◽  
Jiabing Miao ◽  
Yongbing Liu ◽  
Tao Zhou ◽  
Litao Song
Keyword(s):  
Reactive Extraction ◽  
Cyclodextrin Derivatives ◽  
Equilibrium Studies

Equilibrium studies on enantioselective extraction of oxybutynin enantiomers by hydrophilic β-cyclodextrin derivatives

AIChE Journal ◽  
2011 ◽  
Vol 57 (11) ◽  
pp. 3027-3036 ◽  
Author(s):  
Kewen Tang ◽  
Panliang Zhang ◽  
Chunyue Pan ◽  
Hongjian Li
Keyword(s):  
Cyclodextrin Derivatives ◽  
Equilibrium Studies ◽  
Enantioselective Extraction

Enantioselective extraction of hydrophilic 2-chloromandelic acid enantiomers by hydroxypropyl-β-cyclodextrin: experiments and modeling

2013 ◽  
Vol 67 (2) ◽  
Author(s):  
Cong-Shan Zhou ◽  
Ping Xu ◽  
Ke-Wen Tang ◽  
Xin-Yu Jiang ◽  
Tao Yang ◽  
...  
Keyword(s):  
Aqueous Phase ◽  
Extraction Efficiency ◽  
Reactive Extraction ◽  
Phase Reaction ◽  
Important Process ◽  
Process Variables ◽  
Model Data ◽  
Cyclodextrin Derivatives ◽  
Enantioselective Extraction ◽  
Extraction Model

AbstractEnantioselective extraction of hydrophilic 2-chloromandelic acid (CMA) enantiomers from organic to aqueous phase with hydroxypropyl-β-cyclodextrin (HP-β-CD) as the selector was investigated. Equilibrium of the extraction system was modeled using a reactive extraction model with a homogeneous aqueous phase reaction. The influence of important process variables on the extraction efficiency, such as the type of the organic solvent and β-cyclodextrin derivatives (β-CDs), concentration of the selector, pH and temperature, was investigated by experiment and modeling. Important parameters of this model were determined experimentally. Results showed that the experimental data agree with the model prediction perfectly and the model was further applied to accurately predict the extraction efficiency influenced simultaneously by pH and the concentration of HP-β-CD. Combining the experiment and the model data, the best extraction conditions were: pH of 2.5, HP-β-CD concentration of 0.05 mol L−1, and temperature of 5°C, providing the enantioselectivity of 1.285 and the performance factor (pf) of 0.011.

Equilibrium & kinetic studies of reactive extraction of trans-aconitic acid using sunflower oil with tri-n-octylamine

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Rajesh Nimmakayala ◽  
Dharm Pal ◽  
Dhananjay Singh ◽  
Abhinesh Kumar Prajapati
Keyword(s):  
Sunflower Oil ◽  
Fermentation Broth ◽  
Kinetic Studies ◽  
Reactive Extraction ◽  
Equilibrium Studies ◽  
Aconitic Acid ◽  
Equilibrium And Kinetics ◽  
Loading Ratio ◽  
Stirred Cell ◽  
Complex Formations

Abstract In order to design an efficient extraction system for the separation of biochemically produced trans-aconitic acid (TAH) from fermentation broth; equilibrium and kinetics of reactive extraction of TAH from aqueous solutions was investigated using tri-n-octylamine (TOA) as an extractant and sunflower oil as a diluent. Through the equilibrium studies stoichiometry (acid, extractant) of complex formations was determined with the help of loading ratio. Formation of (1, 1), (2, 1), & (3, 1) stoichiometry complexes were observed having complexation constants values 179.73 kmol−1 m3, 9512.58 kmol−2 m6, and 614,407.02 kmol−3 m9, respectively. Kinetics experiments were performed in Lewis type stirred cell and results confirmed that reaction between TAH and TOA in sunflower oil fall in regime 1, i.e. slow reaction occurring in bulk organic phase. The overall order of reaction is pseudo first order with rate constant (K mn ) 1.78 × 10−5 (kmol m−3)−0.71 s−1 and physical mass transfer coefficient (K l ) 4.22 × 10−5 m s−1.

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