Chirality Control by Substituents in the Asymmetric Addition of Et2Zn to Aromatic Aldehydes Catalyzed bycis-(1R,2S)-2-Benzamidocyclohexanecarboxylic Acid Derived 1,3-Aminoalcohols

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Guangyou Zhang
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Xiao-Feng Yang ◽  
Guang-You Zhang

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Activation of imines of aromatic aldehydes by N-glycosylation with O-pivaloyl-galactopyranosyl bromide (pivalobromogalactose) and subsequent addition of organotin, organolithium, Grignard, or organozinc reagents afforded α-arylalkylamines with moderate to high diastereoselectivity.


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