Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin

2008 ◽  
Vol 26 (8) ◽  
pp. 1385-1389 ◽  
Author(s):  
Qiu-Ju ZHOU ◽  
Ya-Jing BI ◽  
Jun-Feng XIANG ◽  
Ya-Lin TANG ◽  
Qian-Fan YANG ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals The Therapeutic Effect of Human Serum Albumin Dimer-Doxorubicin Complex against Human Pancreatic Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1209
Author(s):  
Ryo Kinoshita ◽  
Yu Ishima ◽  
Victor T. G. Chuang ◽  
Hiroshi Watanabe ◽  
Taro Shimizu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Antitumor Drug ◽  
Pancreatic Tumors

Human serum albumin (HSA) is a versatile drug carrier with active tumor targeting capacity for an antitumor drug delivery system. Nanoparticle albumin-bound (nab)-technology, such as nab-paclitaxel (Abraxane®︎), has attracted significant interest in drug delivery research. Recently, we demonstrated that HSA dimer (HSA-d) possesses a higher tumor distribution than HSA monomer (HSA-m). Therefore, HSA-d is more suitable as a drug carrier for antitumor therapy and can improve nab technology. This study investigated the efficacy of HSA-d-doxorubicin (HSA-d-DOX) as next-generation nab technology for tumor treatment. DOX conjugated to HSA-d via a tunable pH-sensitive linker for the controlled release of DOX. Lyophilization did not affect the particle size of HSA-d-DOX or the release of DOX. HSA-d-DOX showed significantly higher cytotoxicity than HSA-m-DOX in vitro. In the SUIzo Tumor-2 (SUIT2) human pancreatic tumor subcutaneous inoculation model, HSA-d-DOX could significantly inhibit tumor growth without causing serious side effects, as compared to the HSA binding DOX prodrug, which utilized endogenous HSA as a nano-drug delivery system (DDS) carrier. These results indicate that HSA-d could function as a natural solubilizer of insoluble drugs and an active targeting carrier in intractable tumors with low vascular permeability, such as pancreatic tumors. In conclusion, HSA-d can be an effective drug carrier for the antitumor drug delivery system against human pancreatic tumors.

Preparation and formulation optimization of methotrexate-loaded human serum albumin nanoparticles modified by mannose

2021 ◽  
Vol 28 ◽  
Author(s):  
Zhenyu Chen ◽  
Zhongling Luo ◽  
Jiayao Lyu ◽  
Jianxin Wang ◽  
Zhongbing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Circulation Time ◽  
Independent Variables ◽  
Albumin Nanoparticles

Background: Methotrexate (MTX) is the representative drug among the disease-modifying anti-rheumatic drugs. But the conventional treatment with MTX showed many limitations and side effects. Objective: To strengthen the targeting ability and circulation time of MTX in the treatment of rheumatoid arthritis, the present study focused on developing a novel drug delivery system of methotrexate-loaded human serum albumin nanoparticles (MTX-NPs) modified by mannose, which referred as MTX-M-NPs. Methods: Firstly, mannose-derived carboxylic acid was synthesized and further modified on the surface of MTX-NPs to prepare MTX-M-NPs. The formulation of nanoparticles was optimized by method of central composite design (CCD), with the drug lipid ratio, oil-aqueous ratio, and cholesterol or lecithin weight as the independent variables. The average particle size and encapsulation efficiency were the response variables. Response of different formulations was calculated and the response surface diagram, contour diagram and mathematical equation were used to relate the dependent and independent variables to predict the optimal formula ratio. The uptake of MTX-M-NPs by neutrophils was studied through the laser confocal detection. Further, MTX-M-NPs was subjected to assess the pharmacokinetics profile after intravenous injection with Sprague-Dawley rats. Results: This targeting drug delivery system was successfully developed. Results from Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy analysis can verify the successful preparation of this drug delivery system. Based on the optimized formula, MTX-M-NPs was prepared with a particle size of 188.17 ± 1.71 nm and an encapsulation rate of 95.55 ± 0.33%. MTX-M-NPs displayed significantly higher cellular uptake than MTX-NPs. The pharmacokinetic results showed that MTX-M-NPs could prolong the in vivo circulation time of MTX. Conclusion: This targeting drug delivery system laid a promising foundation for the treatment of RA.

A near infrared light-triggered human serum albumin drug delivery system with coordination bonding of indocyanine green and cisplatin for targeting photochemistry therapy against oral squamous cell cancer

2019 ◽  
Vol 7 (12) ◽  
pp. 5270-5282 ◽  
Author(s):  
Yuxin Wang ◽  
Diya Xie ◽  
Jiongru Pan ◽  
Chengwan Xia ◽  
Lei Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Cell Cancer ◽  
Infrared Light

To ensure site–specific drug release in tumor cells and cancer-associated fibroblasts and reduce the systemic toxicity of chemotherapy, a novel drug delivery system called human serum albumin-indocyanine green-cisplatin nanoparticles was developed.

Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 214-222 ◽  
Author(s):  
Oznur Akbal ◽  
Tayfun Vural ◽  
Soheil Malekghasemi ◽  
Betül Bozdoğan ◽  
Emir Baki Denkbaş
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System

Thiolated human serum albumin cross-linked dextran hydrogels as a macroscale delivery system

Soft Matter ◽  
2014 ◽  
Vol 10 (27) ◽  
pp. 4869-4874 ◽  
Author(s):  
Yue Gao ◽  
Roxanne E. Kieltyka ◽  
Wim Jesse ◽  
Ben Norder ◽  
Alexander V. Korobko ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Delivery System ◽  
Drug Carrier ◽  
System P ◽  
Cross Linker ◽  
Hydrogel System

A biohybrid hydrogel system using human serum albumin as a simultaneous drug carrier and covalent cross-linker was established for macroscale drug delivery.

Non-toxic sonochemical synthesis of surface functionalized human serum albumin nanocapsules for targeted drug delivery

2012 ◽  
Vol 29 ◽  
pp. S228
Author(s):  
A. Rollett ◽  
T. Reiter ◽  
P. Nogueira ◽  
M. Cardinale ◽  
A. Loureiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Targeted Drug Delivery ◽  
Sonochemical Synthesis ◽  
Targeted Drug
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