Ionic gelation of chitosan with sodium tripolyphosphate using a novel combined nebulizer and falling film system

2021 ◽  
Author(s):  
Yeganeh Poureghbal ◽  
Masoud Rahimi ◽  
Mona Akbari
Keyword(s):  
Sodium Tripolyphosphate ◽  
Ionic Gelation ◽  
Falling Film ◽  
Film System

SINTESIS DAN KARAKTERISASI NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana)

2013 ◽  
Vol 14 (3) ◽  
Author(s):  
Eriawan Rismana ◽  
Susi Kusumaningrum ◽  
Olivia Bunga P ◽  
Idah Rosidah ◽  
Marhamah Marhamah
Keyword(s):  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Chitosan Solution ◽  
The Other ◽  
Ionic Gelation ◽  
Garcinia Mangostana ◽  
Particle Size Analyzer ◽  
Cadmium Lead ◽  
Solvent Residue ◽  
Mold And Yeast

The chitosan – Garcinia Mangostana extract nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia Mangostana extract and it’s continued by reaction process with 0.1 % sodium tripolyphosphate. The particle size of material was determined by Particle Size Analyzer (PSA) that it showed in the range of 200 – 500 nm. The color, pH, water, α- mangostin, mercury, arsenic, cadmium, lead, totally microbe aerobic, totally mold and yeast, and solvent residue contents of nanoparticles were also examined by many methods that these resulted are yellow, 4.50 – 5.50, 89 – 90 %, 1.05 %, < 0.005 ppm, < 0.01 ppm, < 0.01 ppm, < 0.05 ppm, < 10 CFU/g, < 10 CFU/g and not detected, respectively. The other characterization was also observed that it’sincluded stability andTLC chromatogram. A mixture of nanoparticles with cosmetics bases was showed that it’s increased stability, homogeneity and easy to formed.

Preparation of Thermoresponsive Chitosan Polymers and Its Application Controlling Release of Antifouling Agent

2013 ◽  
Vol 562-565 ◽  
pp. 664-667 ◽  
Author(s):  
Feng Ling Xu ◽  
Cun Guo Lin ◽  
Ji Yong Zheng ◽  
Jin Wei Zhang ◽  
Li Wang
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Encapsulation Efficiency ◽  
Sodium Tripolyphosphate ◽  
Ionic Gelation ◽  
Gelation Process ◽  
Chitosan Microparticles ◽  
Antifouling Agent ◽  
Physicochemical Structure ◽  
Scanning Electron

Thermoresponsive chitosan copolymers embed with antifouling agent paeonol in chitosan(CS) microparticles were prepared and the release dynamics was studied at different temperature. Chitosan microparticles have been formed based on ionic gelation process of CS and sodium tripolyphosphate (TPP). Paeonol was incorporated into the CS microparticles with the size about 0.1 μm. The physicochemical structure of samples was analyzed by FTIR and scanning electron microscopy (SEM). We investigated the influence of sodium tripolyphosphate (TPP) and paeonol on Encapsulation efficiency. Increasing TPP concentration from 1 to 3 mg/ml increased encapsulation efficiency of paeonol from 63% to 92%. Increasing peaonol concentration from 1.0 to 3.0 mg/ml increased peaonol encapsulation efficiency from 72% to 85%.

scholarly journals Chitosan anchored nanoparticles for breast cancer: preparation and evaluation: part-I

2019 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Rajkumari Thagele ◽  
Archana Bagre ◽  
Mohan Lal Kori
Keyword(s):  
Breast Cancer ◽  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Polymeric Nanoparticles ◽  
Research Work ◽  
Chitosan Nanoparticles ◽  
Physical Factors ◽  
Ionic Gelation ◽  
Shell Nanoparticles ◽  
Preparation And Evaluation

The objective of present research work was to develop methotrexate loaded chitosan anchored shell nanoparticles for drug delivery in breast cancer. Chitosan nanoparticles (CS-NPs) were synthesized by ionic gelation of chitosan using sodium tripolyphosphate (STPP). The optimized nanoparticles were characterized for particle size and polydispersity index (PDI) revealed particle size were found to be between 57.08 nm to169.5 nm and PDI 0.252 to 0.639 respectively. The results signpost that stirring speed during ionic gelation reaction was also decisive parameters for the size of the nanoparticles obtained. Further characterization involved to show polymer-drug interaction was FTIR and DSC. This paper grants a revision of the physical factors elaborate in attaining nanoparticles in order to regulate the particle size of polymeric nanoparticles made from chitosan, without any surplus chemical treatment. Keywords: Breast cancer, Nanoparticles, Chitosan, Methotrexate

scholarly journals Facile Fabrication of Polysaccharide Nanocomposites Using Ionic Gelation Method

2021 ◽  
Vol 3 (1) ◽  
pp. 37-45
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Pooneh Kia ◽  
Hemra Hamrayev
Keyword(s):  
Sodium Tripolyphosphate ◽  
Ionic Gelation ◽  
X Ray ◽  
Chitosan Coating ◽  
Natural Cellulose ◽  
Facile Fabrication ◽  
Cross Linker ◽  
Coating Agents ◽  
Multifunctional Properties ◽  
Scanning Electron

Polysaccharide-based nanomaterials with significant biocompatibility and physiochemical features have been widely analyzed in modern biomedical nanotechnology. Chitosan-coating is an advantageous procedure to provide several pharmacological characteristics of chitosan on the reinforcement. Here, we fabricated polysaccharide nanocomposites using the facile ionic gelation method and sodium tripolyphosphate (TPP) cross-linker. The polysaccharide nanocomposites comprised natural cellulose and chitosan as reinforcement and coating agents, respectively. From the image of the scanning electron microscope, the nanocomposites indicated almost spherical dimensions with sizes below 60 nm. Results from X-ray powder diffraction and Fourier-transform infrared spectroscopy showed multifunctional properties of the nanocomposites related to both cellulose and chitosan. Therefore, the ionic gelation method is potentially appropriate to synthesize the polysaccharide nanocomposites for medically-related applications.

scholarly journals Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2010 ◽  
Author(s):  
Yattra Jampafuang ◽  
Anan Tongta ◽  
Yaowapha Waiprib
Keyword(s):  
Superoxide Radical ◽  
Sodium Tripolyphosphate ◽  
Radical Scavenging Activity ◽  
Chitosan Nanoparticles ◽  
Radical Scavenging ◽  
Crystallinity Index ◽  
Superoxide Radicals ◽  
Dependent Manner ◽  
Ionic Gelation ◽  
Nanoparticle Formation

α- and β-Chitosan nanoparticles were obtained from shrimp shell and squid pen chitosan with different set of deacetylation degree (%DD) and molecular weight (MW) combinations. After nanoparticle formation via ionic gelation with sodium tripolyphosphate (TPP), the % crystallinity index (%CI) of the α- and β-chitosan nanoparticles were reduced to approximately 33% and 43% of the initial %CI of the corresponding α- and β-chitosan raw samples, respectively. Both forms of chitosan and chitosan nanoparticles scavenged superoxide radicals in a dose-dependent manner. The %CI of α- and β-chitosan and chitosan nanoparticles was significantly negatively correlated with superoxide radical scavenging abilities over the range of concentration (0.5, 1, 2 and 3 mg/mL) studied. High %DD, and low MW β-chitosan exhibited the highest superoxide radical scavenging activity (p < 0.05). α- and β-Chitosan nanoparticles prepared from high %DD and low MW chitosan demonstrated the highest abilities to scavenge superoxide radicals at 2.0–3.0 mg/mL (p < 0.05), whereas α-chitosan nanoparticles, with the lowest %CI, and smallest particle size (p < 0.05), prepared from medium %DD, and medium MW chitosan showed the highest abilities to scavenge superoxide radicals at 0.5–1.0 mg/mL (p < 0.05). It could be concluded that α- and β-chitosan nanoparticles had superior superoxide radical scavenging abilities than raw chitosan samples.

scholarly journals PREPARATION OF CHITOSAN-TPP NANOPARTICLES: THE INFLUENCE OF CHITOSAN POLYMERIC PROPERTIES AND FORMULATION VARIABLES

2018 ◽  
Vol 10 (5) ◽  
pp. 60 ◽  
Author(s):  
N. K. Al-nemrawi ◽  
S. S. M. Alsharif ◽  
R. H. Dave
Keyword(s):  
Freeze Drying ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Great Influence ◽  
Ionic Gelation ◽  
Drying Method ◽  
Experimental Conditions ◽  
Large Increment ◽  
The Stability ◽  
Formulation Variables

Objective: The aim of this work was to prepare chitosan nanoparticles (CS NPs) using sodium tripolyphosphate (TPP) as crosslinker and to study the effect of chitosan polymeric properties and experimental conditions on the properties and stability of NPs.Methods: CS NPs were prepared by ionic gelation method, using TPP as a crosslinker. The particle size (PS), polydispersity index (PDI), zeta potential (ZP) and the morphologies of the NPs were studied. CS NPs prepared by varying the concentration of TPP, Chitosan molecular weight and its degree of deacetylation, the stirring speed, the rate of TPP addition and the freeze-drying method to study the effect of these variables on the NPs. The stability of the CS NPs was evaluated by storing aqueous suspensions of NPs and comparing the PS, PDI and ZP at the beginning and the end of the experiment.Results: This study shows that the PS, ZP and dispersity of the NPs depend on the chitosan polymeric properties and experimental conditions. The NPs sizes range between 145.73 and 724.23 nm. They all carried positive charges ranging between+4.32 and+43.67 mV. Most of the NPs have the same sizes after freeze-drying, but showed higher monodispersity and ZP, indicating higher stability. After twenty days of studying the stability, the NPs that had low ZP showed a large increment in size in comparison to the highly charged NPs.Conclusion: In conclusion, the polymeric properties and formulation variables in the ionic gelation method have a great influence on the CS NPs formed.

scholarly journals Preparation of insulin loaded chitosan- TPP nanoparticles by ionic gelation method

2015 ◽  
Vol 18 (3) ◽  
pp. 125-134
Author(s):  
Trang Thi Huyen Dinh ◽  
Hao Duc Nguyen ◽  
Hieu Van Le ◽  
Ha Thanh Ho
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Concentration Ratio ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Chitosan Concentration

In study, insulin loaded chitosan nanoparticles were prepared via ionic gelation method using cross-linking agent sodium tripolyphosphate (STPP). To have best result for the preparation of nanoparticles, a commercial chitosan with a degree of deacetylation DD of 75 % was adjusted to 85 % - 90 % which was determined by FTIR method. The obtained deacetylated chitosan was studied for the effect of pH, concentration, ratio of chitosan and STPP. Then the insulin loaded chitosan TPP nanoparticles were prepared by ionic gelation method. These nanoparticles could deliver 91.6 % insulin at pH = 3.5, with the chitosan concentration of 1 mg/mL and the chitosan:STPP ratio of 4:1. The TEMs indicate that chitosan nanoparticles were spherical in shape and the particles size was smaller than 100 nm. Investigation of FTIR and entrapment efficiency assert that insulin loaded chitosan nanopartiles have been prepared and can become a drug delivery system via oral in the future.

Synthesis of N-[(2-hydroxyethoxy)carbonyl]glycine from carbon dioxide, ethylene oxide, and α-amino acid by ionic gelation of sodium tripolyphosphate (TPP) and spirulina supported on magnetic KCC-1 in aqueous solution

2018 ◽  
Vol 42 (12) ◽  
pp. 10153-10160 ◽  
Author(s):  
Rahele Zhiani ◽  
Mehdi Khoobi ◽  
Seyed Mohsen Sadeghzadeh
Keyword(s):  
Carbon Dioxide ◽  
Aqueous Solution ◽  
Amino Acid ◽  
Ethylene Oxide ◽  
Sodium Tripolyphosphate ◽  
Ionic Gelation

Ionic gelation supported on Fe3O4/KCC-1 has been developed for the synthesis of N-[(2-hydroxyethoxy)carbonyl]glycine from carbon dioxide, ethylene oxide, and α-amino acid.

Formulation and Characterization of Gefitinib-loaded Polymeric Nanoparticles Using Box-Behnken Design

2019 ◽  
Vol 9 (1) ◽  
pp. 46-60 ◽  
Author(s):  
M. Gupta ◽  
R.K. Marwaha ◽  
H. Dureja
Keyword(s):  
Encapsulation Efficiency ◽  
Sodium Tripolyphosphate ◽  
Polymeric Nanoparticles ◽  
Interactive Effects ◽  
Release Mechanism ◽  
Ionic Gelation ◽  
Box Behnken Design ◽  
Chitosan Concentration ◽  
Systemic Side Effects

Background:Nanotechnology has considerably modified the treatment of cancer by overcoming the prevailing drawbacks in conventional chemotherapy like severe systemic side effects, undesirable bio-distribution and drug resistance.Objective:The objective behind the present study was to develop polymeric nanoparticles loaded with gefitinib by ionic gelation method and optimize the prepared nanoparticles using Box-Behnken Design at 3-factors and 3-levels. The main and interactive effects of three selected process variables i.e chitosan concentration, sodium tripolyphosphate (NaTPP) concentration and NaTPP volume on the encapsulation efficiency and % cumulative drug release were determined.Method:Seventeen nanoparticle formulations were prepared by ionic gelation method using chitosan concentration (0.1-0.3% w/v), NaTPP concentration (0.2-0.6% w/v) and NaTPP volume (8-12 ml) applying Box-behnken design. The cryoprotectant used was 5% w/v trehalose. The nanoparticle formulations were further evaluated for various parameters.Results:The formulation (NP-5) prepared using chitosan (0.1% w/v) and NaTPP (0.4% w/v ) in 8 ml volume exhibited particle size (79.4 nm), polydispersity index (0.349), encapsulation efficiency (82.05 %) and % cumulative drug released (40.83 %) in phosphate buffer (pH 6.8) over a period of 24 h. The release mechanism followed was higuchi model. The values of various evaluation parameters observed were found to be in close concurrence with the values predicted employing the Design expert software.Conclusion:The nanoparticle formulation obtained using chitosan in low concentration, optimum concentration ratio of chitosan: NaTPP along with low volume of NaTPP showed desired features. The mathematical models were further designed to develop polymeric nanoparticles with required characteristics.

One option for the management of wastewater from tofu production: Freeze concentration in a falling-film system

2012 ◽  
Vol 110 (3) ◽  
pp. 364-373 ◽  
Author(s):  
F. Belén ◽  
J. Sánchez ◽  
E. Hernández ◽  
J.M. Auleda ◽  
M. Raventós
Keyword(s):  
Falling Film ◽  
Film System ◽  
Freeze Concentration
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