scholarly journals Process Development for the Integration of Liquid-Liquid Extraction in the Manufacturing Process of Artemisinin

2018 ◽  
Vol 90 (9) ◽  
pp. 1304-1304
Author(s):  
A. Schmidt ◽  
M. Sixt ◽  
J. Strube
Keyword(s):  
Manufacturing Process ◽  
Process Development ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction

scholarly journals Short Alternative Route for Nuclear Fuel Reprocessing Based on Organic Phase Self-Splitting

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6234
Author(s):  
Julie Durain ◽  
Damien Bourgeois ◽  
Murielle Bertrand ◽  
Daniel Meyer
Keyword(s):  
Organic Phase ◽  
Process Development ◽  
Temperature Drop ◽  
Extraction Process ◽  
Liquid Extraction ◽  
Nuclear Industry ◽  
Process Conditions ◽  
Joint Management ◽  
Liquid Liquid Extraction ◽  
Almost All

A more sustainable management of natural resources and the establishment of processes allowing a joint management of nuclear materials to avoid their diversion from their civilian use are two issues for the nuclear industry. Short alternatives to existing processes have therefore been proposed based on known systems available, tributylphosphate (TBP), for the separation of actinides by liquid/liquid extraction. Proof of concept of such alternative has been established on the uranium(VI)/thorium(IV) system. From an organic phase consisting of a mixture of TBP/n-dodecane loaded with uranium and thorium, two fluxes have been obtained: the first contains almost all of the thorium in the presence of uranium in a controlled ratio, the second contains surplus uranium. Two levers were selected to control the spontaneous separation of the organic phase: the addition of concentrated nitric acid, or the temperature variation. Best results have been obtained using a temperature drop in the liquid/liquid extraction process, and variations in process conditions have been studied. Final metal recovery and solvent recycling have also been demonstrated, opening the door for further process development.

Miniature DIAMEX processes in a hollow fibre module micro-plant: process development and optimisation

2008 ◽  
Vol 96 (4-5) ◽  
Author(s):  
Andreas Geist ◽  
Klaus Gompper
Keyword(s):  
Process Development ◽  
Hollow Fibre ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction ◽  
Plant Process

A hollow fibre module (HFM) micro-plant was built to perform continuous liquid-liquid extraction tests with very small feed volumes, using miniature HFM as phase contactors. Spiked DIAMEX tests (

scholarly journals Distinct and Quantitative Validation Method for Predictive Process Modeling with Examples of Liquid-Liquid Extraction Processes of Complex Feed Mixtures

Processes ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 298 ◽  
Author(s):  
Axel Schmidt ◽  
Jochen Strube
Keyword(s):  
Process Model ◽  
Process Development ◽  
Scale Up ◽  
Liquid Extraction ◽  
Process Models ◽  
Parameter Determination ◽  
Production Scale ◽  
Liquid Liquid Extraction ◽  
Safety Margins ◽  
Quantitative Validation

As of today, industrial process development for liquid-liquid extraction and scale-up of extraction columns is based on an experimental procedure that requires tests in pilot-scale. This methodology consumes large amounts of material and time and the utilized scale-up equations are crude estimates including considerable safety margins. This approach is practical for well-known systems or low-value products coupled with high production scale, where such a scale-up methodology has less impact on the overall profitability. However, for new high-value products in biologics manufacturing, a process development based on process understanding and the use of validated process models is imperative. Therefore, a distinct and quantitative validation workflow for liquid-liquid extraction modeling is presented on the example of two complex feed mixtures. Monte-Carlo simulations based on the presented model parameter determination concept result for both examples in prediction accuracy comparable to the experiments and prediction precision within the deviation of the respective experiments. Identification of statistically significant parameters is demonstrated. The presented methodology for model validation will support the implementation of liquid-liquid extraction in the manufacturing of new high value biological products in regulated industries by providing a workflow to derive a Quality-by-Design compatible process model.

scholarly journals Polyphenol Liquid–Liquid Extraction Process Development Using NRTL-SAC

2018 ◽  
Vol 57 (28) ◽  
pp. 9210-9221 ◽  
Author(s):  
Marcelo Silva ◽  
Joan Cortada García ◽  
Marcel Ottens
Keyword(s):  
Process Development ◽  
Extraction Process ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction
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