scholarly journals Pragmatic scale-down approaches in downstream processing for shortening innovation cycles in industrial biotechnology

2018 ◽  
Vol 90 (9) ◽  
pp. 1251-1251
Author(s):  
I. Koudous ◽  
S. Hansen ◽  
W. Blümke
Keyword(s):  
Downstream Processing ◽  
Industrial Biotechnology ◽  
Scale Down

Anaerobic Digestion Enhancement With Microbial Electrolysis Cells

2018 ◽  
pp. 259-269
Author(s):  
Ellie Vipond ◽  
Pattanathu K.S.M. Rahman
Keyword(s):  
Anaerobic Digestion ◽  
Downstream Processing ◽  
Pilot Scale ◽  
Industrial Biotechnology ◽  
Purification Process ◽  
Microbial Electrolysis Cells ◽  
Electrolysis Cells ◽  
Microbial Electrolysis ◽  
Waste Degradation ◽  
Processing Techniques

The engineering of replacements for crude oil is a priority within industrial biotechnology. Biogas, produced by anaerobic digestion (AD) during organic waste degradation, has been used for electricity generation and heating. Microbial electrolysis cells (MECs) are an emerging technology which when combined with AD can produce higher yields of such energy whilst simultaneously treating waste water and sludge. MECs are bioelectrochemical systems which utilize the metabolism of microbes to oxidize organics. The majority of the research has been focused on biohydrogen production, despite associated issues, which has resulted in poor commercialization prospects. Consequently, scientists are now suggesting that methane production should be the focus of MEC technology. This chapter presents lab research on the bioprocessing of biomethane using AD and MECs and addresses important issues, namely the lack of pilot-scale studies. Downstream processing techniques are discussed, as well as a novel suggestion of further utilising MECs in the purification process.

scholarly journals Liquid Biphasic Systems for Oil-Rich Algae Bioproducts Processing

2019 ◽  
Vol 11 (17) ◽  
pp. 4682 ◽  
Author(s):  
Hui Yi Leong ◽  
Chih-Kai Chang ◽  
Jun Wei Lim ◽  
Pau Loke Show ◽  
Dong-Qiang Lin ◽  
...  
Keyword(s):  
Downstream Processing ◽  
Industrial Biotechnology ◽  
Processing Methods ◽  
Disruptive Technologies ◽  
Biphasic Systems ◽  
Processing Techniques ◽  
Oleaginous Algae

Oleaginous algae are nowadays of significance for industrial biotechnology applications and for the welfare of society. Tremendous efforts have been put into the development of economically feasible and effective downstream processing techniques in algae research. Currently, Liquid Biphasic Systems (LBSs) are receiving much attention from academia and industry for their potential as green and effective downstream processing methods. This article serves to review the applications of LBSs (LBS and Liquid Biphasic Flotation System (LBFS)) in the separation, recovery and purification of algae products, as well as their basic working principles. Moreover, cell disruptive technologies incorporated into LBSs in algae research are reported. This review provides insights into the downstream processing in algae industrial biotechnology which could be beneficial for algae biorefinement.

Chemical engineering methods in downstream processing in biotechnology

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
V. Beschkov ◽  
D. Yankov
Keyword(s):  
Chemical Engineering ◽  
Fermentation Broth ◽  
Downstream Processing ◽  
Chemical Technology ◽  
Industrial Biotechnology ◽  
Separation And Purification ◽  
Product Concentration ◽  
Unit Operations ◽  
The Cost

AbstractDownstream processing in industrial biotechnology is a very important part of the overall bioproduct manufacturing. Sometimes the cost for this part of biotechnologies is up to 50% of the overall expenses. It comprises product concentration, separation and purification to different extents, as requested. The usually low product concentrations, the large volumes of fermentation broth and the product sensitivity toward higher temperatures lead to specific methods, similar but not identical to the ones in traditional chemical technology.This article summarizes briefly the unit operations in downstream processing in industrial biotechnology, making a parallel between biotechnology and chemical technology.

Patenting Trends and Innovation in Industrial Biotechnology

2009 ◽  
Author(s):  
Katherine Connor Linton ◽  
Jeremy Wise ◽  
Philip Stone
Keyword(s):  
Industrial Biotechnology

In Silico Study of 1, 4 Alpha Glucan Branching Enzyme and Substrate Docking Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 40-50
Author(s):  
Farzane Kargar ◽  
Amir Savardashtaki ◽  
Mojtaba Mortazavi ◽  
Masoud Torkzadeh Mahani ◽  
Ali Mohammad Amani ◽  
...  
Keyword(s):  
Phylogenetic Tree ◽  
In Silico ◽  
Alpha Helix ◽  
In Silico Analysis ◽  
Glycogen Storage ◽  
Docking Studies ◽  
Random Coil ◽  
Special Topic ◽  
Industrial Biotechnology ◽  
In Silico Study

Background: The 1,4-alpha-glucan branching protein (GlgB) plays an important role in the glycogen biosynthesis and the deficiency in this enzyme has resulted in Glycogen storage disease and accumulation of an amylopectin-like polysaccharide. Consequently, this enzyme was considered a special topic in clinical and biotechnological research. One of the newly introduced GlgB belongs to the Neisseria sp. HMSC071A01 (Ref.Seq. WP_049335546). For in silico analysis, the 3D molecular modeling of this enzyme was conducted in the I-TASSER web server. Methods: For a better evaluation, the important characteristics of this enzyme such as functional properties, metabolic pathway and activity were investigated in the TargetP software. Additionally, the phylogenetic tree and secondary structure of this enzyme were studied by Mafft and Prabi software, respectively. Finally, the binding site properties (the maltoheptaose as substrate) were studied using the AutoDock Vina. Results: By drawing the phylogenetic tree, the closest species were the taxonomic group of Betaproteobacteria. The results showed that the structure of this enzyme had 34.45% of the alpha helix and 45.45% of the random coil. Our analysis predicted that this enzyme has a potential signal peptide in the protein sequence. Conclusion: By these analyses, a new understanding was developed related to the sequence and structure of this enzyme. Our findings can further be used in some fields of clinical and industrial biotechnology.

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